T229B_MOUSE
ID T229B_MOUSE Reviewed; 167 AA.
AC Q8BFQ2; Q3UDU2; Q6AXE5; Q8CCD3;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Transmembrane protein 229B;
GN Name=TMEM229B;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Bone, Bone marrow macrophage, Embryonic lung, Eye, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM229 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC28272.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK031901; BAC27598.1; -; mRNA.
DR EMBL; AK033403; BAC28272.1; ALT_FRAME; mRNA.
DR EMBL; AK036593; BAC29498.1; -; mRNA.
DR EMBL; AK053623; BAC35450.1; -; mRNA.
DR EMBL; AK149922; BAE29169.1; -; mRNA.
DR EMBL; AK151405; BAE30372.1; -; mRNA.
DR EMBL; AK169759; BAE41349.1; -; mRNA.
DR EMBL; BC066067; AAH66067.1; -; mRNA.
DR EMBL; BC079613; AAH79613.1; -; mRNA.
DR CCDS; CCDS26005.1; -.
DR RefSeq; NP_001163872.1; NM_001170401.1.
DR RefSeq; NP_848860.1; NM_178745.4.
DR RefSeq; XP_006515972.1; XM_006515909.2.
DR RefSeq; XP_006515973.1; XM_006515910.3.
DR RefSeq; XP_006515975.1; XM_006515912.3.
DR RefSeq; XP_006515976.1; XM_006515913.1.
DR RefSeq; XP_006515977.1; XM_006515914.1.
DR RefSeq; XP_006515978.1; XM_006515915.3.
DR RefSeq; XP_011242419.1; XM_011244117.2.
DR AlphaFoldDB; Q8BFQ2; -.
DR STRING; 10090.ENSMUSP00000053835; -.
DR MaxQB; Q8BFQ2; -.
DR PaxDb; Q8BFQ2; -.
DR PRIDE; Q8BFQ2; -.
DR ProteomicsDB; 254627; -.
DR Antibodypedia; 52317; 5 antibodies from 5 providers.
DR Ensembl; ENSMUST00000056660; ENSMUSP00000053835; ENSMUSG00000046157.
DR Ensembl; ENSMUST00000070174; ENSMUSP00000070637; ENSMUSG00000046157.
DR Ensembl; ENSMUST00000174072; ENSMUSP00000134376; ENSMUSG00000046157.
DR Ensembl; ENSMUST00000174697; ENSMUSP00000134348; ENSMUSG00000046157.
DR GeneID; 268567; -.
DR KEGG; mmu:268567; -.
DR UCSC; uc007nzm.2; mouse.
DR CTD; 161145; -.
DR MGI; MGI:2444389; Tmem229b.
DR VEuPathDB; HostDB:ENSMUSG00000046157; -.
DR eggNOG; ENOG502QTFF; Eukaryota.
DR GeneTree; ENSGT00390000010899; -.
DR HOGENOM; CLU_102218_0_0_1; -.
DR InParanoid; Q8BFQ2; -.
DR OMA; WDYSQFR; -.
DR OrthoDB; 1476201at2759; -.
DR PhylomeDB; Q8BFQ2; -.
DR TreeFam; TF336481; -.
DR BioGRID-ORCS; 268567; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Tmem229b; mouse.
DR PRO; PR:Q8BFQ2; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8BFQ2; protein.
DR Bgee; ENSMUSG00000046157; Expressed in cortical plate and 217 other tissues.
DR ExpressionAtlas; Q8BFQ2; baseline and differential.
DR Genevisible; Q8BFQ2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009617; P:response to bacterium; IEP:MGI.
DR InterPro; IPR010540; CmpB_TMEM229.
DR Pfam; PF06541; ABC_trans_CmpB; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..167
FT /note="Transmembrane protein 229B"
FT /id="PRO_0000263682"
FT TOPO_DOM 1..14
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..40
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..73
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 148..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 128
FT /note="A -> G (in Ref. 1; BAE29169)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="P -> S (in Ref. 2; AAH79613)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 167 AA; 19561 MW; FF380B0640BDD79E CRC64;
MASAEPLTAL SRWYLYAIHG YFCEVMFTAA WEFVVNFNWK FPGVTSVWAL FIYGTSILIV
ERMYLRLRGR CPLLVRCVIY TLWTYLWEFT TGFILRQFNA CPWDYSQFDF DFMGLITLEY
AVPWFCGALI MEQFIIRNTL RLRFDKDAEP GEPASPPALA NGHVKTD
