T22D1_CHICK
ID T22D1_CHICK Reviewed; 1040 AA.
AC Q91012; Q90840;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=TSC22 domain family protein 1;
DE AltName: Full=Regulatory protein TSC-22;
DE AltName: Full=TGFB-stimulated clone 22 homolog;
DE AltName: Full=Transforming growth factor beta-1-induced transcript 4 protein;
GN Name=TSC22D1; Synonyms=TSC22;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Lens fibers;
RX PubMed=8840185;
RA Sawada K., Agata K., Eguchi G.;
RT "Characterization of terminally differentiated cell state by categorizing
RT cDNA clones derived from chicken lens fibers.";
RL Int. J. Dev. Biol. 40:531-535(1996).
CC -!- FUNCTION: May serve as a transcriptional repressor.
CC -!- SUBUNIT: Homodimer or heterodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q91012-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q91012-2; Sequence=VSP_035332, VSP_035333;
CC -!- SIMILARITY: Belongs to the TSC-22/Dip/Bun family. {ECO:0000305}.
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DR EMBL; D49740; BAA08574.1; -; mRNA.
DR EMBL; D82364; BAA11565.1; -; mRNA.
DR PIR; T29092; T29092.
DR RefSeq; NP_001012778.1; NM_001012760.1.
DR RefSeq; NP_990442.1; NM_205111.1.
DR AlphaFoldDB; Q91012; -.
DR SMR; Q91012; -.
DR STRING; 9031.ENSGALP00000035712; -.
DR PaxDb; Q91012; -.
DR GeneID; 396005; -.
DR KEGG; gga:396005; -.
DR CTD; 8848; -.
DR VEuPathDB; HostDB:geneid_396005; -.
DR eggNOG; KOG4797; Eukaryota.
DR InParanoid; Q91012; -.
DR PhylomeDB; Q91012; -.
DR PRO; PR:Q91012; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR000580; TSC-22_Dip_Bun.
DR Pfam; PF01166; TSC22; 1.
DR PROSITE; PS01289; TSC22; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..1040
FT /note="TSC22 domain family protein 1"
FT /id="PRO_0000219368"
FT REGION 1..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 973..994
FT /note="Leucine-zipper"
FT REGION 1005..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..66
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..221
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..896
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:8840185"
FT /id="VSP_035332"
FT VAR_SEQ 897..937
FT /note="ESSVGASDIADGGSSNVPASVSLFPLKVLPLATPLVDGEDE -> MNAQCCR
FT PAAMDLGVYHLRHSSISFPSSLLGTDSSSLRLDS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:8840185"
FT /id="VSP_035333"
FT CONFLICT 942
FT /note="A -> V (in Ref. 1; BAA08574)"
FT /evidence="ECO:0000305"
FT CONFLICT 948..950
FT /note="DNK -> ENM (in Ref. 1; BAA08574)"
FT /evidence="ECO:0000305"
FT CONFLICT 1011
FT /note="Q -> K (in Ref. 1; BAA11565)"
FT /evidence="ECO:0000305"
FT CONFLICT 1016
FT /note="P -> S (in Ref. 1; BAA11565)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1040 AA; 105930 MW; 027EDC1E49176DFA CRC64;
MFPRRGSSSS SGSSCVTAPT APGTGVGSAA LSAEDYQPPL LVQPPPPSPA ASSSAGPQPT
PPPPQSLNLL SQSQLQPQPL AQTGAQMKKK SGFQITSVTP AQISASMSSN NSIAEDTESY
DDLDESHTED LSSSEILDVS LSRATDLGEP ERSSSEETLN NFQEAETPGA VSPNQPHLPQ
QHPSLPHHPQ QSVVINGSVH PHHVHHHHHL HHHHHGHHHP SHPGVGSAPV SAGPPPSPSF
RKLSTTGSSD NVISAAPGSA ASSTGSPASV VSNIRTTSTP GNLGVSSATG TSTLNNMGAG
SSSVASSMLG AMNLSNITST GNVNALSGTS GNVNVNILSG VGNGTSASSS VVNNVTNPSA
GVAAGSSQQQ PASGTSRFRV VKLDSSSDPF KKGRWTCTEF YDKENTVAAS EGVAVNKAVE
TIKQNPLEVT SERESTSGSS VSSNVSTLSH YTESVGSGEM GAPTVVQQQA SQGVGPQQMD
FSSTAPPAIP ASSIPQSVSQ SQLAQVQLHS QEINYPQEKP GVQPPAQASL TTVTGVQPAP
VNLLGVSPAL GHQQPAIQSM AQQELPYSQP AQPVQTLPVV QQQQLQYGQQ QQQQQAVPTQ
MATGHVKSVN QNSVTGAVSE YIQHQQILQP PAPAMQPSPA GVGGGPPVPV AQAPSMQSAV
PVHPAAAPAQ PVAHAPAAIP GVGTSGQMLS VGQQANVAAV VYPPPAANQI PPPVMPSTAA
PPSSQVVQPV QTGIMQQGLQ ASASGLPQQM VIAQQNTLLP VQPQAQAVES VVQGMTGQQL
PAVSPIPSAS TVPAPSQAGS AVPPGIPSAS IGLGQPQNIA QASAVQNGNL AQSVSQPPLV
STSIGMPVAP SVPQQIPLSS TQFPAQSLAQ PVVSQMEDGR RPTEPSLVGL PQAASGESSV
GASDIADGGS SNVPASVSLF PLKVLPLATP LVDGEDESSS GASVVAIDNK IEQAMDLVKS
HLMYAVREEV EVLKEQIKEL IEKNSQLEQE NTLLKTLASP EQLAQFQAQL QTGSPPSSGQ
AQGTAQQPAQ PASQGSGPSA
