T22D1_HUMAN
ID T22D1_HUMAN Reviewed; 1073 AA.
AC Q15714; B3KRL7; B9EGI0; O00666; Q6AHX5; Q6IBU1; Q8NCN1; Q96JS5;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 3.
DT 03-AUG-2022, entry version 191.
DE RecName: Full=TSC22 domain family protein 1;
DE AltName: Full=Cerebral protein 2;
DE AltName: Full=Regulatory protein TSC-22;
DE AltName: Full=TGFB-stimulated clone 22 homolog;
DE AltName: Full=Transforming growth factor beta-1-induced transcript 4 protein;
GN Name=TSC22D1; Synonyms=KIAA1994, TGFB1I4, TSC22; ORFNames=hucep-2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=8651929; DOI=10.1006/bbrc.1996.0825;
RA Jay P., Wei J.W., Marsollier C., Taviaux S., Berge-Lefranc J.-L., Berta P.;
RT "Cloning of the human homologue of the TGF beta-stimulated clone 22 gene.";
RL Biochem. Biophys. Res. Commun. 222:821-826(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Kidney;
RX PubMed=9022669; DOI=10.1111/j.1432-1033.1996.460rr.x;
RA Ohta S., Shimekake Y., Nagata K.;
RT "Molecular cloning and characterization of a transcription factor for the
RT C-type natriuretic peptide gene promoter.";
RL Eur. J. Biochem. 242:460-466(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=9026990;
RA Dmitrenko V.V., Garifulin O.M., Shostak E.A., Smikodub A.I., Kavsan V.M.;
RT "The characteristics of different types of mRNA expressed in the human
RT brain.";
RL Cyt. Genet. 30:41-47(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Brain cortex;
RA Yazaki M., Takayama K., Matsumoto K., Yoshimoto M.;
RT "Hucep-2, a gene which is expressed in the human brain, is a homologue of
RT rodent and chicken TSC-22.";
RL Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Kawamata H., Uchida D., Omotehara F., Hino S., Nakashiro K., Miwa Y.,
RA Begum N., Hoque M.O., Yoshida H., Sato M.;
RT "Cloning and characterization of human TSC-22 genomic DNA.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=12056414; DOI=10.1093/dnares/9.2.47;
RA Ohara O., Nagase T., Mitsui G., Kohga H., Kikuno R., Hiraoka S.,
RA Takahashi Y., Kitajima S., Saga Y., Koseki H.;
RT "Characterization of size-fractionated cDNA libraries generated by the in
RT vitro recombination-assisted method.";
RL DNA Res. 9:47-57(2002).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
RC TISSUE=Brain cortex, and Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Fetal brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [11]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [12]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, Colon, Lung, Ovary, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [13]
RP CHARACTERIZATION.
RX PubMed=10488076; DOI=10.1074/jbc.274.39.27439;
RA Kester H.A., Blanchetot C., den Hertog J., van der Saag P.T.,
RA van der Burg B.;
RT "Transforming growth factor-beta-stimulated clone-22 is a member of a
RT family of leucine zipper proteins that can homo- and heterodimerize and has
RT transcriptional repressor activity.";
RL J. Biol. Chem. 274:27439-27447(1999).
RN [14]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [15]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Transcriptional repressor. Acts on the C-type natriuretic
CC peptide (CNP) promoter.
CC -!- SUBUNIT: Homodimer or heterodimer. Can form a heterodimer with TSC22D4.
CC -!- INTERACTION:
CC Q15714; Q96HA8: NTAQ1; NbExp=4; IntAct=EBI-712609, EBI-741158;
CC Q15714; P13693: TPT1; NbExp=5; IntAct=EBI-712609, EBI-1783169;
CC Q15714-2; P05067: APP; NbExp=3; IntAct=EBI-12034704, EBI-77613;
CC Q15714-2; Q9H8Y8: GORASP2; NbExp=8; IntAct=EBI-12034704, EBI-739467;
CC Q15714-2; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-12034704, EBI-741158;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q15714-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q15714-2; Sequence=VSP_035325, VSP_035326;
CC Name=3;
CC IsoId=Q15714-3; Sequence=VSP_035324;
CC Name=4;
CC IsoId=Q15714-4; Sequence=VSP_044939, VSP_044940;
CC -!- TISSUE SPECIFICITY: Widely expressed in fetal and adult tissues.
CC -!- INDUCTION: In aortic endothelial cells, induced by cytokines, including
CC TGFB1.
CC -!- SIMILARITY: Belongs to the TSC-22/Dip/Bun family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC02703.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U35048; AAC50566.1; -; mRNA.
DR EMBL; D38585; BAA07598.1; -; mRNA.
DR EMBL; AJ222700; CAA10951.1; -; mRNA.
DR EMBL; D87061; BAB46917.1; -; mRNA.
DR EMBL; AF256226; AAG53077.1; -; Genomic_DNA.
DR EMBL; AB082525; BAC02703.1; ALT_INIT; mRNA.
DR EMBL; AK091854; BAG52429.1; -; mRNA.
DR EMBL; AK312345; BAG35266.1; -; mRNA.
DR EMBL; CR456711; CAG32992.1; -; mRNA.
DR EMBL; CR627459; CAH10539.1; -; mRNA.
DR EMBL; AL138960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL139184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL356107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471075; EAX08710.1; -; Genomic_DNA.
DR EMBL; BC000456; AAH00456.1; -; mRNA.
DR EMBL; BC016867; AAH16867.1; -; mRNA.
DR EMBL; BC069207; AAH69207.1; -; mRNA.
DR EMBL; BC105277; AAI05278.1; -; mRNA.
DR EMBL; BC136475; AAI36476.1; -; mRNA.
DR EMBL; BC136482; AAI36483.1; -; mRNA.
DR EMBL; BC146664; AAI46665.1; -; mRNA.
DR EMBL; BC146679; AAI46680.1; -; mRNA.
DR CCDS; CCDS31966.1; -. [Q15714-1]
DR CCDS; CCDS58291.1; -. [Q15714-4]
DR CCDS; CCDS9392.1; -. [Q15714-2]
DR PIR; JC4813; JC4813.
DR RefSeq; NP_001230728.1; NM_001243799.1. [Q15714-4]
DR RefSeq; NP_006013.1; NM_006022.3. [Q15714-2]
DR RefSeq; NP_904358.2; NM_183422.3. [Q15714-1]
DR AlphaFoldDB; Q15714; -.
DR SMR; Q15714; -.
DR BioGRID; 114374; 97.
DR IntAct; Q15714; 55.
DR MINT; Q15714; -.
DR STRING; 9606.ENSP00000397435; -.
DR GlyGen; Q15714; 3 sites, 1 O-linked glycan (3 sites).
DR iPTMnet; Q15714; -.
DR MetOSite; Q15714; -.
DR PhosphoSitePlus; Q15714; -.
DR BioMuta; TSC22D1; -.
DR DMDM; 334302874; -.
DR EPD; Q15714; -.
DR jPOST; Q15714; -.
DR MassIVE; Q15714; -.
DR MaxQB; Q15714; -.
DR PaxDb; Q15714; -.
DR PeptideAtlas; Q15714; -.
DR PRIDE; Q15714; -.
DR ProteomicsDB; 3607; -.
DR ProteomicsDB; 60713; -. [Q15714-1]
DR ProteomicsDB; 60714; -. [Q15714-2]
DR ProteomicsDB; 60715; -. [Q15714-3]
DR TopDownProteomics; Q15714-3; -. [Q15714-3]
DR Antibodypedia; 23553; 476 antibodies from 31 providers.
DR DNASU; 8848; -.
DR Ensembl; ENST00000261489.6; ENSP00000261489.2; ENSG00000102804.15. [Q15714-2]
DR Ensembl; ENST00000458659.3; ENSP00000397435.2; ENSG00000102804.15. [Q15714-1]
DR Ensembl; ENST00000501704.3; ENSP00000437414.1; ENSG00000102804.15. [Q15714-4]
DR GeneID; 8848; -.
DR KEGG; hsa:8848; -.
DR MANE-Select; ENST00000458659.3; ENSP00000397435.2; NM_183422.4; NP_904358.2.
DR UCSC; uc001uzm.5; human. [Q15714-1]
DR CTD; 8848; -.
DR DisGeNET; 8848; -.
DR GeneCards; TSC22D1; -.
DR HGNC; HGNC:16826; TSC22D1.
DR HPA; ENSG00000102804; Low tissue specificity.
DR MIM; 607715; gene.
DR neXtProt; NX_Q15714; -.
DR OpenTargets; ENSG00000102804; -.
DR PharmGKB; PA134887618; -.
DR VEuPathDB; HostDB:ENSG00000102804; -.
DR eggNOG; KOG4797; Eukaryota.
DR GeneTree; ENSGT00940000159144; -.
DR HOGENOM; CLU_148757_0_0_1; -.
DR InParanoid; Q15714; -.
DR OMA; EDSGHQQ; -.
DR OrthoDB; 1602203at2759; -.
DR PhylomeDB; Q15714; -.
DR TreeFam; TF318837; -.
DR PathwayCommons; Q15714; -.
DR SignaLink; Q15714; -.
DR SIGNOR; Q15714; -.
DR BioGRID-ORCS; 8848; 16 hits in 1101 CRISPR screens.
DR ChiTaRS; TSC22D1; human.
DR GeneWiki; TSC22D1; -.
DR GenomeRNAi; 8848; -.
DR Pharos; Q15714; Tbio.
DR PRO; PR:Q15714; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q15714; protein.
DR Bgee; ENSG00000102804; Expressed in endothelial cell and 217 other tissues.
DR ExpressionAtlas; Q15714; baseline and differential.
DR Genevisible; Q15714; HS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc.
DR InterPro; IPR000580; TSC-22_Dip_Bun.
DR Pfam; PF01166; TSC22; 1.
DR PROSITE; PS01289; TSC22; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Nucleus; Phosphoprotein;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..1073
FT /note="TSC22 domain family protein 1"
FT /id="PRO_0000219365"
FT REGION 22..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1006..1027
FT /note="Leucine-zipper"
FT REGION 1037..1073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..84
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..238
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..624
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 263
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT VAR_SEQ 1..921
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:8651929,
FT ECO:0000303|PubMed:9022669, ECO:0000303|PubMed:9026990,
FT ECO:0000303|Ref.4, ECO:0000303|Ref.8"
FT /id="VSP_035325"
FT VAR_SEQ 1..488
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_035324"
FT VAR_SEQ 557..570
FT /note="QQKQGLQPVPLQAT -> LTMKVVLLIVYLCM (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044939"
FT VAR_SEQ 571..1073
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044940"
FT VAR_SEQ 922..970
FT /note="VGLPQTISGDSGGMSAVSDGSSSSLAASASLFPLKVLPLTTPLVDGEDE ->
FT MKSQWCRPVAMDLGVYQLRHFSISFLSSLLGTENASVRLDN (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:8651929,
FT ECO:0000303|PubMed:9022669, ECO:0000303|PubMed:9026990,
FT ECO:0000303|Ref.4, ECO:0000303|Ref.8"
FT /id="VSP_035326"
FT VARIANT 652
FT /note="P -> S (in dbSNP:rs9525983)"
FT /id="VAR_057311"
FT CONFLICT 332
FT /note="M -> I (in Ref. 6; BAC02703)"
FT /evidence="ECO:0000305"
FT CONFLICT 581
FT /note="P -> L (in Ref. 12; CAH10539)"
FT /evidence="ECO:0000305"
FT CONFLICT 661
FT /note="P -> S (in Ref. 12; CAH10539)"
FT /evidence="ECO:0000305"
FT CONFLICT Q15714-2:15
FT /note="V -> A (in Ref. 4; BAB46917)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1073 AA; 109677 MW; BFA471E36FCD06BD CRC64;
MHQPPESTAA AAAAADISAR KMAHPAMFPR RGSGSGSASA LNAAGTGVGS NATSSEDFPP
PSLLQPPPPA ASSTSGPQPP PPQSLNLLSQ AQLQAQPLAP GGTQMKKKSG FQITSVTPAQ
ISASISSNNS IAEDTESYDD LDESHTEDLS SSEILDVSLS RATDLGEPER SSSEETLNNF
QEAETPGAVS PNQPHLPQPH LPHLPQQNVV INGNAHPHHL HHHHQIHHGH HLQHGHHHPS
HVAVASASIT GGPPSSPVSR KLSTTGSSDS ITPVAPTSAV SSSGSPASVM TNMRAPSTTG
GIGINSVTGT STVNNVNITA VGSFNPNVTS SMLGNVNIST SNIPSAAGVS VGPGVTSGVN
VNILSGMGNG TISSSAAVSS VPNAAAGMTG GSVSSQQQQP TVNTSRFRVV KLDSSSEPFK
KGRWTCTEFY EKENAVPATE GVLINKVVET VKQNPIEVTS ERESTSGSSV SSSVSTLSHY
TESVGSGEMG APTVVVQQQQ QQQQQQQQQP ALQGVTLQQM DFGSTGPQSI PAVSIPQSIS
QSQISQVQLQ SQELSYQQKQ GLQPVPLQAT MSAATGIQPS PVNVVGVTSA LGQQPSISSL
AQPQLPYSQA APPVQTPLPG APPPQQLQYG QQQPMVSTQM APGHVKSVTQ NPASEYVQQQ
PILQTAMSSG QPSSAGVGAG TTVIPVAQPQ GIQLPVQPTA VPAQPAGASV QPVGQAPAAV
SAVPTGSQIA NIGQQANIPT AVQQPSTQVP PSVIQQGAPP SSQVVPPAQT GIIHQGVQTS
APSLPQQLVI ASQSSLLTVP PQPQGVEPVA QGIVSQQLPA VSSLPSASSI SVTSQVSSTG
PSGMPSAPTN LVPPQNIAQT PATQNGNLVQ SVSQPPLIAT NTNLPLAQQI PLSSTQFSAQ
SLAQAIGSQI EDARRAAEPS LVGLPQTISG DSGGMSAVSD GSSSSLAASA SLFPLKVLPL
TTPLVDGEDE SSSGASVVAI DNKIEQAMDL VKSHLMYAVR EEVEVLKEQI KELIEKNSQL
EQENNLLKTL ASPEQLAQFQ AQLQTGSPPA TTQPQGTTQP PAQPASQGSG PTA
