ID   T22D1_MACFA             Reviewed;         144 AA.
AC   Q4R4H5;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=TSC22 domain family protein 1;
GN   Name=TSC22D1; ORFNames=QccE-12168;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor. Acts on the C-type natriuretic
CC       peptide (CNP) promoter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer or heterodimer. Can form a heterodimer with TSC22D4
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TSC-22/Dip/Bun family. {ECO:0000305}.
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DR   EMBL; AB169919; BAE02000.1; -; mRNA.
DR   RefSeq; XP_005585828.1; XM_005585771.2.
DR   AlphaFoldDB; Q4R4H5; -.
DR   SMR; Q4R4H5; -.
DR   STRING; 9541.XP_005585825.1; -.
DR   Ensembl; ENSMFAT00000008016; ENSMFAP00000033788; ENSMFAG00000003381.
DR   GeneID; 102118164; -.
DR   KEGG; mcf:102118164; -.
DR   CTD; 8848; -.
DR   VEuPathDB; HostDB:ENSMFAG00000003381; -.
DR   eggNOG; KOG4797; Eukaryota.
DR   GeneTree; ENSGT00940000159144; -.
DR   Proteomes; UP000233100; Chromosome 17.
DR   Bgee; ENSMFAG00000003381; Expressed in frontal cortex and 13 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR000580; TSC-22_Dip_Bun.
DR   Pfam; PF01166; TSC22; 1.
DR   PROSITE; PS01289; TSC22; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..144
FT                   /note="TSC22 domain family protein 1"
FT                   /id="PRO_0000285809"
FT   REGION          76..97
FT                   /note="Leucine-zipper"
FT   REGION          109..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   144 AA;  15680 MW;  B8AEF42657C50892 CRC64;
     MKSQWCRPVA MDLGVYQLRH FSISFLSSLL GTENASVRLD NSSSGASVVA IDNKIEQAMD
     LVKSHLMYAV REEVEVLKEQ IKELIEKNSQ LEQENNLLKT LASPEQLAQF QAQLQTGSPP
     ATTQPQGTTQ PPAQPASQGS GPTA