T22D1_PONAB
ID T22D1_PONAB Reviewed; 1070 AA.
AC Q5R4H1; Q5R4J3;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=TSC22 domain family protein 1;
GN Name=TSC22D1;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional repressor. Acts on the C-type natriuretic
CC peptide (CNP) promoter (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer or heterodimer. Can form a heterodimer with TSC22D4
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5R4H1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5R4H1-2; Sequence=VSP_035330, VSP_035331;
CC -!- SIMILARITY: Belongs to the TSC-22/Dip/Bun family. {ECO:0000305}.
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DR EMBL; CR861255; CAH93323.1; -; mRNA.
DR EMBL; CR861277; CAH93345.1; -; mRNA.
DR RefSeq; NP_001126956.1; NM_001133484.1. [Q5R4H1-1]
DR RefSeq; NP_001126969.1; NM_001133497.1. [Q5R4H1-2]
DR AlphaFoldDB; Q5R4H1; -.
DR SMR; Q5R4H1; -.
DR STRING; 9601.ENSPPYP00000006071; -.
DR Ensembl; ENSPPYT00000059441; ENSPPYP00000032635; ENSPPYG00000005330. [Q5R4H1-2]
DR GeneID; 100173988; -.
DR KEGG; pon:100173988; -.
DR CTD; 8848; -.
DR eggNOG; KOG4797; Eukaryota.
DR GeneTree; ENSGT00940000159144; -.
DR InParanoid; Q5R4H1; -.
DR OrthoDB; 1602203at2759; -.
DR Proteomes; UP000001595; Chromosome 13.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR000580; TSC-22_Dip_Bun.
DR Pfam; PF01166; TSC22; 1.
DR PROSITE; PS01289; TSC22; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Nucleus; Phosphoprotein;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..1070
FT /note="TSC22 domain family protein 1"
FT /id="PRO_0000285810"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 830..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1003..1024
FT /note="Leucine-zipper"
FT REGION 1034..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..84
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..238
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..621
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 263
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q15714"
FT VAR_SEQ 1..926
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_035330"
FT VAR_SEQ 927..967
FT /note="GDSGGMSAVSDGSSSSLAASASLFPLKVLPLTTPLVDGEDE -> MKSQWCR
FT PVAMDLGVYQLRHFSISFLSSLLGTENASVRLDN (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_035331"
SQ SEQUENCE 1070 AA; 109499 MW; E4C1F97F90AC86C2 CRC64;
MHQPPESTAA ATAAADISAR KMAHPAMFPR RGSGSGSASA LNAAGTGVGS NATSSEDFPP
PSLLQPPPPA ASSTSGPQPP PPQSLNLLSQ AQLQAQPLAP GGTQMKKKSG FQITSVTPAQ
ISASISSNNS IAEDTESYDD LDESHTEDLS SSEILDVSLS RATDLGEPER SSSEETLNNF
QEAETPGAVS PNQPHLPQPH LPHLPQQNVV INGNAHPHHL HHHHHIHHGH HLQHGHHHPS
HVAVASASIP GGPPPSPVTR KLSTTGSSDS ITPVAPTSAV SSSGSPASVM TNMRAPSTTG
GIGINSVTGT STVNNVNITA VGSFNPNVTS SMLGNVNIST SNIPSAASVS VGPGVTSGVN
VNILSGMGNG TISSSAAVNS VPNAAAGMTG GSISSQQQQP TVNTSRFRVV KLDSSSEPFK
KGRWTCTEFY EKENAVPATE GVLINKVVET VKQNPIEVTS ERESTSGSSV SSSVSTRSHY
TESVGSGEMG APTVVVQQQQ QQQQQQPALQ GVTLQQMDFG STGPQSIPAV SIPQSISQSQ
ISQVQLQSQE LSYQQKQGLQ PVPLQATMSA ATGIQPSPVN VVGVTSALGQ QPSISSLAQP
QLPYSQAAPP VQTPLPGAPP PQQLQYGQQQ PMVSTQMAPG HVKSVTQNPA SEYVQQQPIL
QTAMSSGQPS SAGVGAGTTV IPVAQPQGIQ LPVQPTAVPA QPTGASVQPV GQAQAAVSAV
PTGSQIANIG QQANIPTAVQ QPSTQVPPSV IQQGAPPSSQ VVPPAQTGII HQGVQTSAPS
LPQQLVIASQ SSLLTVPPQP QGVEPVAQGI VSQQLPAVSP LPSASSISVT SQVSSAGPSG
MPSAPTNLVP PQNIAQTPAT QNGNLVQSVS QPPLIATNIN LPLAQQIPLS STQFSAQSLA
QAIGSQIEDA RHAAEPSLVG LPQTISGDSG GMSAVSDGSS SSLAASASLF PLKVLPLTTP
LVDGEDESSS GASVVAIDNK IEQAMDLVKS HLMYAVREEV EVLKEQIKEL IEKNSQLEQE
NNLLKTLASP EQLAQFQAQL QTGSPPATTQ PQGTTQPPAQ PASQGSGPTA
