ID   T22D1_RAT               Reviewed;         143 AA.
AC   P62501; A0JPR0; Q00992;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=TSC22 domain family protein 1;
DE   AltName: Full=Regulatory protein TSC-22;
DE   AltName: Full=TGFB-stimulated clone 22 homolog;
DE   AltName: Full=Transforming growth factor beta-1-induced transcript 4 protein;
GN   Name=Tsc22d1; Synonyms=Tgfb1i4, Tsc22;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Testis;
RX   PubMed=8161377; DOI=10.1210/endo.134.3.8161377;
RA   Hamil K.G., Hall S.H.;
RT   "Cloning of rat Sertoli cell follicle-stimulating hormone primary response
RT   complementary deoxyribonucleic acid: regulation of TSC-22 gene
RT   expression.";
RL   Endocrinology 134:1205-1212(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9022669; DOI=10.1111/j.1432-1033.1996.460rr.x;
RA   Ohta S., Shimekake Y., Nagata K.;
RT   "Molecular cloning and characterization of a transcription factor for the
RT   C-type natriuretic peptide gene promoter.";
RL   Eur. J. Biochem. 242:460-466(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver, and Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transcriptional repressor. Acts on the C-type natriuretic
CC       peptide (CNP) promoter.
CC   -!- SUBUNIT: Homodimer or heterodimer. Can form a heterodimer with TSC22D4
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Fairly ubiquitous, slightly higher in bone.
CC   -!- INDUCTION: By transforming growth factor beta-1 and other growth
CC       factors.
CC   -!- SIMILARITY: Belongs to the TSC-22/Dip/Bun family. {ECO:0000305}.
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DR   EMBL; L25785; AAA20685.1; -; mRNA.
DR   EMBL; BC059146; AAH59146.1; -; mRNA.
DR   EMBL; BC127547; AAI27548.1; -; mRNA.
DR   RefSeq; NP_037175.1; NM_013043.2.
DR   AlphaFoldDB; P62501; -.
DR   SMR; P62501; -.
DR   BioGRID; 269855; 2.
DR   STRING; 10116.ENSRNOP00000055007; -.
DR   jPOST; P62501; -.
DR   PaxDb; P62501; -.
DR   PRIDE; P62501; -.
DR   Ensembl; ENSRNOT00000001360; ENSRNOP00000001360; ENSRNOG00000001030.
DR   GeneID; 498545; -.
DR   KEGG; rno:498545; -.
DR   UCSC; RGD:3850; rat.
DR   CTD; 8848; -.
DR   RGD; 3850; Tsc22d1.
DR   eggNOG; KOG4797; Eukaryota.
DR   GeneTree; ENSGT00940000159144; -.
DR   HOGENOM; CLU_148757_0_0_1; -.
DR   InParanoid; P62501; -.
DR   PRO; PR:P62501; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000001030; Expressed in ovary and 19 other tissues.
DR   ExpressionAtlas; P62501; baseline and differential.
DR   Genevisible; P62501; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR   InterPro; IPR000580; TSC-22_Dip_Bun.
DR   Pfam; PF01166; TSC22; 1.
DR   PROSITE; PS01289; TSC22; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..143
FT                   /note="TSC22 domain family protein 1"
FT                   /id="PRO_0000219367"
FT   REGION          76..97
FT                   /note="Leucine-zipper"
FT   REGION          108..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   143 AA;  15583 MW;  729D4688572496F0 CRC64;
     MKSQWCRPVA MDLGVYQLRH FSISFLSSLL GTENASVRLD NSSGASVVAI DNKIEQAMDL
     VKSHLMYAVR EEVEVLKEQI KELIEKNSQL EQENNLLKTL ASPEQLAQFQ AQLQTGSPPA
     TTQPQGTTQP PAQPASQGSG STA