T22D2_HUMAN
ID T22D2_HUMAN Reviewed; 780 AA.
AC O75157; D3DNI5; Q6PI50; Q9H2Z6; Q9H2Z7; Q9H2Z8;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 3.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=TSC22 domain family protein 2;
DE AltName: Full=TSC22-related-inducible leucine zipper protein 4;
GN Name=TSC22D2; Synonyms=KIAA0669, TILZ4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9734811; DOI=10.1093/dnares/5.3.169;
RA Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H.,
RA Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. X. The
RT complete sequences of 100 new cDNA clones from brain which can code for
RT large proteins in vitro.";
RL DNA Res. 5:169-176(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 544-780 (ISOFORMS 1 AND 2).
RA Ershler M.A., Belyavsky A.V., Visser J.W.M.;
RT "Identification and characterization of a family of leucine zipper genes
RT related to TSC22.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=TILZ4a, TILZ4c;
CC IsoId=O75157-1; Sequence=Displayed;
CC Name=2; Synonyms=TILZ4b;
CC IsoId=O75157-2; Sequence=VSP_013202;
CC -!- SIMILARITY: Belongs to the TSC-22/Dip/Bun family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA31644.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB014569; BAA31644.2; ALT_INIT; mRNA.
DR EMBL; CH471052; EAW78838.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78839.1; -; Genomic_DNA.
DR EMBL; BC044643; AAH44643.1; -; mRNA.
DR EMBL; AF201290; AAG41223.1; -; mRNA.
DR EMBL; AF201291; AAG41224.1; -; mRNA.
DR EMBL; AF201292; AAG41225.1; -; mRNA.
DR CCDS; CCDS3149.1; -. [O75157-1]
DR PIR; T00366; T00366.
DR RefSeq; NP_001290193.1; NM_001303264.1. [O75157-2]
DR RefSeq; NP_055594.1; NM_014779.3. [O75157-1]
DR AlphaFoldDB; O75157; -.
DR SMR; O75157; -.
DR BioGRID; 115158; 61.
DR IntAct; O75157; 8.
DR STRING; 9606.ENSP00000354543; -.
DR GlyGen; O75157; 9 sites, 2 O-linked glycans (9 sites).
DR iPTMnet; O75157; -.
DR MetOSite; O75157; -.
DR PhosphoSitePlus; O75157; -.
DR BioMuta; TSC22D2; -.
DR EPD; O75157; -.
DR jPOST; O75157; -.
DR MassIVE; O75157; -.
DR MaxQB; O75157; -.
DR PaxDb; O75157; -.
DR PeptideAtlas; O75157; -.
DR PRIDE; O75157; -.
DR ProteomicsDB; 49825; -. [O75157-1]
DR ProteomicsDB; 49826; -. [O75157-2]
DR Antibodypedia; 1698; 153 antibodies from 24 providers.
DR DNASU; 9819; -.
DR Ensembl; ENST00000361875.8; ENSP00000354543.2; ENSG00000196428.13. [O75157-1]
DR Ensembl; ENST00000688009.1; ENSP00000510392.1; ENSG00000196428.13. [O75157-2]
DR GeneID; 9819; -.
DR KEGG; hsa:9819; -.
DR MANE-Select; ENST00000688009.1; ENSP00000510392.1; NM_001303264.2; NP_001290193.1. [O75157-2]
DR UCSC; uc003exv.4; human. [O75157-1]
DR CTD; 9819; -.
DR DisGeNET; 9819; -.
DR GeneCards; TSC22D2; -.
DR HGNC; HGNC:29095; TSC22D2.
DR HPA; ENSG00000196428; Low tissue specificity.
DR MIM; 617724; gene.
DR neXtProt; NX_O75157; -.
DR OpenTargets; ENSG00000196428; -.
DR PharmGKB; PA142670697; -.
DR VEuPathDB; HostDB:ENSG00000196428; -.
DR eggNOG; KOG4797; Eukaryota.
DR GeneTree; ENSGT00940000160465; -.
DR HOGENOM; CLU_020315_0_0_1; -.
DR InParanoid; O75157; -.
DR OMA; EKMNQPS; -.
DR OrthoDB; 1602203at2759; -.
DR PhylomeDB; O75157; -.
DR TreeFam; TF318837; -.
DR PathwayCommons; O75157; -.
DR SignaLink; O75157; -.
DR BioGRID-ORCS; 9819; 219 hits in 1108 CRISPR screens.
DR ChiTaRS; TSC22D2; human.
DR GenomeRNAi; 9819; -.
DR Pharos; O75157; Tdark.
DR PRO; PR:O75157; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; O75157; protein.
DR Bgee; ENSG00000196428; Expressed in buccal mucosa cell and 207 other tissues.
DR ExpressionAtlas; O75157; baseline and differential.
DR Genevisible; O75157; HS.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR000580; TSC-22_Dip_Bun.
DR Pfam; PF01166; TSC22; 1.
DR PROSITE; PS01289; TSC22; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..780
FT /note="TSC22 domain family protein 2"
FT /id="PRO_0000219369"
FT REGION 20..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..284
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 653..676
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_013202"
FT VARIANT 419
FT /note="A -> T (in dbSNP:rs879634)"
FT /id="VAR_052408"
SQ SEQUENCE 780 AA; 79228 MW; 5ED799E741944A01 CRC64;
MSKMPAKKKS CFQITSVTTA QVATSITEDT ESLDDPDESR TEDVSSEIFD VSRATDYGPE
EVCERSSSEE TLNNVGDAET PGTVSPNLLL DGQLAAAAAA PANGGGVVSA RSVSGALAST
LAAAATSAPA PGAPGGPQLA GSSAGPVTAA PSQPPTTCSS RFRVIKLDHG SGEPYRRGRW
TCMEYYERDS DSSVLTRSGD CIRHSSTFDQ TAERDSGLGA TGGSVVVVVA SMQGAHGPES
GTDSSLTAVS QLPPSEKMSQ PTPAQPQSFS VGQPQPPPPP VGGAVAQSSA PLPPFPGAAT
GPQPMMAAAQ PSQPQGAGPG GQTLPPTNVT LAQPAMSLPP QPGPAVGAPA AQQPQQFAYP
QPQIPPGHLL PVQPSGQSEY LQQHVAGLQP PSPAQPSSTG AAASPATAAT LPVGTGQNAS
SVGAQLMGAS SQPSEAMAPR TGPAQGGQVA PCQPTGVPPA TVGGVVQPCL GPAGAGQPQS
VPPPQMGGSG PLSAVPGGPH AVVPGVPNVP AAVPAPSVPS VSTTSVTMPN VPAPLAQSQQ
LSSHTPVSRS SSIIQHVGLP LAPGTHSAPT SLPQSDLSQF QTQTQPLVGQ VDDTRRKSEP
LPQPPLSLIA ENKPVVKPPV ADSLANPLQL TPMNSLATSV FSIAIPVDGD EDRNPSTAFY
QAFHLNTLKE SKSLWDSASG GGVVAIDNKI EQAMDLVKSH LMYAVREEVE VLKEQIKELV
ERNSLLEREN ALLKSLSSND QLSQLPTQQA NPGSTSQQQA VIAQPPQPTQ PPQQPNVSSA
