T22D4_RAT
ID T22D4_RAT Reviewed; 387 AA.
AC Q3B8N7;
DT 13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=TSC22 domain family protein 4;
DE AltName: Full=TSC22-related-inducible leucine zipper protein 2;
DE AltName: Full=Thg-1pit;
GN Name=Tsc22d4; Synonyms=Tilz2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165; THR-223 AND SER-271, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Transcriptional repressor. {ECO:0000250}.
CC -!- SUBUNIT: Forms a homodimer or heterodimer. Can form a heterodimer with
CC TSC22D1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TSC-22/Dip/Bun family. {ECO:0000305}.
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DR EMBL; CH473973; EDM13242.1; -; Genomic_DNA.
DR EMBL; BC105911; AAI05912.1; -; mRNA.
DR RefSeq; NP_001037749.1; NM_001044284.3.
DR RefSeq; XP_006249139.1; XM_006249077.3.
DR RefSeq; XP_017459950.1; XM_017604461.1.
DR AlphaFoldDB; Q3B8N7; -.
DR SMR; Q3B8N7; -.
DR STRING; 10116.ENSRNOP00000033658; -.
DR iPTMnet; Q3B8N7; -.
DR PhosphoSitePlus; Q3B8N7; -.
DR jPOST; Q3B8N7; -.
DR PaxDb; Q3B8N7; -.
DR PRIDE; Q3B8N7; -.
DR Ensembl; ENSRNOT00000039280; ENSRNOP00000033658; ENSRNOG00000050805.
DR GeneID; 684980; -.
DR KEGG; rno:684980; -.
DR CTD; 81628; -.
DR RGD; 1584380; Tsc22d4.
DR eggNOG; KOG4797; Eukaryota.
DR GeneTree; ENSGT00940000161400; -.
DR HOGENOM; CLU_052826_0_0_1; -.
DR InParanoid; Q3B8N7; -.
DR OMA; FYFFPDA; -.
DR OrthoDB; 1602203at2759; -.
DR PhylomeDB; Q3B8N7; -.
DR PRO; PR:Q3B8N7; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Proteomes; UP000234681; Chromosome 12.
DR Bgee; ENSRNOG00000024616; Expressed in heart and 19 other tissues.
DR ExpressionAtlas; Q3B8N7; baseline and differential.
DR Genevisible; Q3B8N7; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006970; P:response to osmotic stress; ISO:RGD.
DR InterPro; IPR000580; TSC-22_Dip_Bun.
DR InterPro; IPR042553; TSC22D4.
DR PANTHER; PTHR47610; PTHR47610; 1.
DR Pfam; PF01166; TSC22; 1.
DR PROSITE; PS01289; TSC22; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..387
FT /note="TSC22 domain family protein 4"
FT /id="PRO_0000417669"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..357
FT /note="Leucine-zipper"
FT REGION 368..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..48
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 57
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3Q8"
FT MOD_RES 62
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3Q8"
FT MOD_RES 165
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 183
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9EQN3"
FT MOD_RES 187
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9EQN3"
FT MOD_RES 189
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9EQN3"
FT MOD_RES 223
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 254
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9EQN3"
FT MOD_RES 258
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9EQN3"
FT MOD_RES 271
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 362
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3Q8"
SQ SEQUENCE 387 AA; 40041 MW; 20B00F4ACFB8F739 CRC64;
MSGGKKKSSF QITSVTTDYE GPGSPGASDP PAPPAPAGPP PRLPNGEPNP DPGGRGTPRN
GSPPPGAPAS RFRVVKLPQG LGEPYRRGRW TCVDVYERDL EPPSFGRLLE GIRGASGGTG
GRSLDSRLEL ASLGISTPIP QPGLSQGPTS WLRPPPTSPG PQARSFTGGL GQLAGPGKAK
VETPPLSASP PQQRPPGPGT GDSAQTLPSL RVEVESGGLA AGTPPLSRRR DGAVRLRMEL
VAPEETGKVP PIDSRPNSPA LYFDASLVHK SPDPFGAAAA QSLSLARSML AISGHLDSDD
DSGSGSLVGI DNKIEQAMDL VKSHLMFAVR EEVEVLKEQI RDLAERNAAL EQENGLLRAL
ASPEQLAQLP SSGLPRLGPS APNGPSI
