BPC1_ARATH
ID BPC1_ARATH Reviewed; 283 AA.
AC Q9SKD0; Q6U1Z7; Q8L9F3;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Protein BASIC PENTACYSTEINE1;
DE Short=AtBPC1;
GN Name=BPC1; OrderedLocusNames=At2g01930; ORFNames=F23I14.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DNA-BINDING, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=14731261; DOI=10.1046/j.1365-313x.2003.01971.x;
RA Meister R.J., Williams L.A., Monfared M.M., Gallagher T.L., Kraft E.A.,
RA Nelson C.G., Gasser C.S.;
RT "Definition and interactions of a positive regulatory element of the
RT Arabidopsis INNER NO OUTER promoter.";
RL Plant J. 37:426-438(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia; TISSUE=Rosette leaf;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP FUNCTION, DNA-BINDING, AND DEVELOPMENTAL STAGE.
RX PubMed=15722463; DOI=10.1105/tpc.104.030130;
RA Kooiker M., Airoldi C.A., Losa A., Manzotti P.S., Finzi L., Kater M.M.,
RA Colombo L.;
RT "BASIC PENTACYSTEINE1, a GA binding protein that induces conformational
RT changes in the regulatory region of the homeotic Arabidopsis gene
RT SEEDSTICK.";
RL Plant Cell 17:722-729(2005).
RN [8]
RP GENE FAMILY.
RA Bloss U., Hohenstatt M.L., Hummel S., Harter K., Wanke D.;
RT "The plant specific BPC/BBR family of GAGA-repeat binding proteins.";
RL (In) Proceedings of the 20th international conference on Arabidopsis
RL research, abstract#084, Edinburgh (2009).
RN [9]
RP TISSUE SPECIFICITY.
RX PubMed=21435046; DOI=10.1111/j.1365-313x.2011.04562.x;
RA Monfared M.M., Simon M.K., Meister R.J., Roig-Villanova I., Kooiker M.,
RA Colombo L., Fletcher J.C., Gasser C.S.;
RT "Overlapping and antagonistic activities of BASIC PENTACYSTEINE genes
RT affect a range of developmental processes in Arabidopsis.";
RL Plant J. 66:1020-1031(2011).
CC -!- FUNCTION: Transcriptional regulator that specifically binds to GA-rich
CC elements (GAGA-repeats) present in regulatory sequences of genes
CC involved in developmental processes. Negatively regulates the homeotic
CC gene AGL11/STK, which controls ovule primordium identity, by a
CC cooperative binding to purine-rich elements present in the regulatory
CC sequence leading to DNA conformational changes.
CC {ECO:0000269|PubMed:14731261, ECO:0000269|PubMed:15722463}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in seedlings, leaves and pistils.
CC Detected in the base of flowers and tips of carpels, in leaf and sepal
CC vasculature, in young rosette, in the lateral and tip of primary roots,
CC and in the whole ovule. {ECO:0000269|PubMed:14731261,
CC ECO:0000269|PubMed:21435046}.
CC -!- DEVELOPMENTAL STAGE: Early detected in the floral meristem and floral
CC organ primordia. At later stages, expressed in all floral organs and in
CC particular in the ovule. {ECO:0000269|PubMed:15722463}.
CC -!- SIMILARITY: Belongs to the BBR/BPC family. {ECO:0000305}.
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DR EMBL; AY380334; AAR28441.1; -; mRNA.
DR EMBL; AC007265; AAM15473.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC05521.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC05522.1; -; Genomic_DNA.
DR EMBL; AY065225; AAL38701.1; -; mRNA.
DR EMBL; AY096550; AAM20200.1; -; mRNA.
DR EMBL; AK317471; BAH20136.1; -; mRNA.
DR EMBL; AY088464; AAM66000.1; -; mRNA.
DR PIR; H84430; H84430.
DR RefSeq; NP_565279.1; NM_126254.3.
DR RefSeq; NP_973398.1; NM_201669.2.
DR AlphaFoldDB; Q9SKD0; -.
DR BioGRID; 127; 11.
DR IntAct; Q9SKD0; 8.
DR STRING; 3702.AT2G01930.2; -.
DR iPTMnet; Q9SKD0; -.
DR PaxDb; Q9SKD0; -.
DR PRIDE; Q9SKD0; -.
DR ProteomicsDB; 240806; -.
DR EnsemblPlants; AT2G01930.1; AT2G01930.1; AT2G01930.
DR EnsemblPlants; AT2G01930.2; AT2G01930.2; AT2G01930.
DR GeneID; 814724; -.
DR Gramene; AT2G01930.1; AT2G01930.1; AT2G01930.
DR Gramene; AT2G01930.2; AT2G01930.2; AT2G01930.
DR KEGG; ath:AT2G01930; -.
DR Araport; AT2G01930; -.
DR TAIR; locus:2045842; AT2G01930.
DR eggNOG; ENOG502QRPH; Eukaryota.
DR HOGENOM; CLU_039119_2_0_1; -.
DR InParanoid; Q9SKD0; -.
DR OMA; HPEPHMS; -.
DR OrthoDB; 1257222at2759; -.
DR PhylomeDB; Q9SKD0; -.
DR PRO; PR:Q9SKD0; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SKD0; baseline and differential.
DR Genevisible; Q9SKD0; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:TAIR.
DR GO; GO:1901002; P:positive regulation of response to salt stress; IGI:TAIR.
DR GO; GO:0050793; P:regulation of developmental process; IGI:TAIR.
DR GO; GO:0080157; P:regulation of plant-type cell wall organization or biogenesis; IGI:TAIR.
DR GO; GO:0009723; P:response to ethylene; IGI:TAIR.
DR InterPro; IPR010409; GAGA-bd_tscrpt_act.
DR PANTHER; PTHR31421; PTHR31421; 1.
DR Pfam; PF06217; GAGA_bind; 1.
DR SMART; SM01226; GAGA_bind; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..283
FT /note="Protein BASIC PENTACYSTEINE1"
FT /id="PRO_0000413435"
FT REGION 111..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 88
FT /note="N -> T (in strain: cv. Landsberg erecta)"
FT CONFLICT 100
FT /note="Q -> H (in Ref. 6; AAM66000)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="P -> A (in Ref. 6; AAM66000)"
FT /evidence="ECO:0000305"
FT CONFLICT 166
FT /note="Q -> QQK (in Ref. 6; AAM66000)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 283 AA; 31648 MW; BAFBFCBD92262E07 CRC64;
MDDDGFRNWG YYEPAAASSF KGNLGLQLMS TIDRNTKPFL PGRESNLMIG SNGSYHSREQ
DMNYSWINQP KDNKFFNMLP ISTPSYSNVL SETSGSNSIQ MIHQPVLNSS RFEENPIPPP
APCEEQTGKK RKMRGSIATP TVPKAKKMRK PKEERDVTNN NVQQQQQRVK PVKKSVDLVI
NGVSMDISGL PVPVCTCTGT PQQCYRWGCG GWQSACCTTN ISVYPLPMST KRRGARISGR
KMSQGAFKKV LEKLSTEGYS FGNAIDLKSH WARHGTNKFV TIR
