T255A_HUMAN
ID T255A_HUMAN Reviewed; 349 AA.
AC Q5JRV8; A8K0W9; B1APR4; B3KPI6; E9PAR3; Q86Y72; Q9NWN8;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Transmembrane protein 255A;
DE AltName: Full=Protein FAM70A;
GN Name=TMEM255A; Synonyms=FAM70A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLN-345.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q5JRV8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5JRV8-2; Sequence=VSP_021920, VSP_021921;
CC Name=3;
CC IsoId=Q5JRV8-3; Sequence=VSP_046825;
CC Name=4;
CC IsoId=Q5JRV8-4; Sequence=VSP_046826;
CC -!- SIMILARITY: Belongs to the TMEM255 family. {ECO:0000305}.
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DR EMBL; AK000723; BAA91341.1; -; mRNA.
DR EMBL; AK289684; BAF82373.1; -; mRNA.
DR EMBL; AK056403; BAG51698.1; -; mRNA.
DR EMBL; AC002086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL512286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC047054; AAH47054.1; -; mRNA.
DR CCDS; CCDS14597.1; -. [Q5JRV8-1]
DR CCDS; CCDS43986.1; -. [Q5JRV8-3]
DR CCDS; CCDS48157.1; -. [Q5JRV8-4]
DR RefSeq; NP_001098014.1; NM_001104544.1. [Q5JRV8-3]
DR RefSeq; NP_001098015.1; NM_001104545.1. [Q5JRV8-4]
DR RefSeq; NP_060408.3; NM_017938.3. [Q5JRV8-1]
DR AlphaFoldDB; Q5JRV8; -.
DR BioGRID; 120356; 34.
DR IntAct; Q5JRV8; 11.
DR STRING; 9606.ENSP00000310110; -.
DR TCDB; 9.B.200.1.1; the 4 tms tmem255 or pfam fam70 (tmem255) family.
DR iPTMnet; Q5JRV8; -.
DR PhosphoSitePlus; Q5JRV8; -.
DR BioMuta; TMEM255A; -.
DR DMDM; 74741910; -.
DR MassIVE; Q5JRV8; -.
DR PaxDb; Q5JRV8; -.
DR PeptideAtlas; Q5JRV8; -.
DR PRIDE; Q5JRV8; -.
DR Antibodypedia; 29876; 92 antibodies from 18 providers.
DR DNASU; 55026; -.
DR Ensembl; ENST00000309720.9; ENSP00000310110.5; ENSG00000125355.16. [Q5JRV8-1]
DR Ensembl; ENST00000371352.5; ENSP00000360403.1; ENSG00000125355.16. [Q5JRV8-2]
DR Ensembl; ENST00000371369.9; ENSP00000360420.4; ENSG00000125355.16. [Q5JRV8-3]
DR Ensembl; ENST00000440464.5; ENSP00000405781.1; ENSG00000125355.16. [Q5JRV8-4]
DR GeneID; 55026; -.
DR KEGG; hsa:55026; -.
DR MANE-Select; ENST00000371369.9; ENSP00000360420.4; NM_001104544.3; NP_001098014.1. [Q5JRV8-3]
DR UCSC; uc004eso.5; human. [Q5JRV8-1]
DR CTD; 55026; -.
DR GeneCards; TMEM255A; -.
DR HGNC; HGNC:26086; TMEM255A.
DR HPA; ENSG00000125355; Tissue enhanced (brain, ovary).
DR neXtProt; NX_Q5JRV8; -.
DR OpenTargets; ENSG00000125355; -.
DR PharmGKB; PA142671885; -.
DR VEuPathDB; HostDB:ENSG00000125355; -.
DR eggNOG; ENOG502QVX8; Eukaryota.
DR GeneTree; ENSGT00940000160471; -.
DR HOGENOM; CLU_068698_1_0_1; -.
DR InParanoid; Q5JRV8; -.
DR OMA; MWASNAP; -.
DR PhylomeDB; Q5JRV8; -.
DR TreeFam; TF331034; -.
DR PathwayCommons; Q5JRV8; -.
DR SignaLink; Q5JRV8; -.
DR BioGRID-ORCS; 55026; 9 hits in 693 CRISPR screens.
DR ChiTaRS; TMEM255A; human.
DR GenomeRNAi; 55026; -.
DR Pharos; Q5JRV8; Tdark.
DR PRO; PR:Q5JRV8; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5JRV8; protein.
DR Bgee; ENSG00000125355; Expressed in substantia nigra pars reticulata and 137 other tissues.
DR ExpressionAtlas; Q5JRV8; baseline and differential.
DR Genevisible; Q5JRV8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR InterPro; IPR028014; TMEM255.
DR PANTHER; PTHR33721; PTHR33721; 1.
DR Pfam; PF14967; FAM70; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..349
FT /note="Transmembrane protein 255A"
FT /id="PRO_0000266037"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 303..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..164
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021920"
FT VAR_SEQ 141..164
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_046825"
FT VAR_SEQ 142..249
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_046826"
FT VAR_SEQ 165
FT /note="E -> M (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021921"
FT VARIANT 345
FT /note="P -> Q (in dbSNP:rs17854410)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_029637"
FT CONFLICT 319
FT /note="P -> S (in Ref. 1; BAG51698)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 349 AA; 38449 MW; 0ABBA85AFF20F7BC CRC64;
MHQSLTQQRS SDMSLPDSMG AFNRRKRNSI YVTVTLLIVS VLILTVGLAA TTRTQNVTVG
GYYPGVILGF GSFLGIIGSN LIENKRQMLV ASIVFISFGV IAAFCCAIVD GVFAARHIDL
KPLYANRCHY VPKTSQKEAE EVISSSTKNS PSTRVMRNLT QAAREVNCPH LSREFCTPRI
RGNTCFCCDL YNCGNRVEIT GGYYEYIDVS SCQDIIHLYH LLWSATILNI VGLFLGIITA
AVLGGFKDMN PTLPALNCSV ENTHPTVSYY AHPQVASYNT YYHSPPHLPP YSAYDFQHSG
VFPSSPPSGL SDEPQSASPS PSYMWSSSAP PRYSPPYYPP FEKPPPYSP
