T255A_MOUSE
ID T255A_MOUSE Reviewed; 351 AA.
AC Q8BHW5; Q6P5C9; Q8BHV8; Q8BHZ6;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Transmembrane protein 255A;
DE AltName: Full=Protein FAM70A;
GN Name=Tmem255a; Synonyms=Fam70a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Olfactory bulb, Testis, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BHW5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BHW5-2; Sequence=VSP_021922;
CC Name=3;
CC IsoId=Q8BHW5-3; Sequence=VSP_021923;
CC -!- SIMILARITY: Belongs to the TMEM255 family. {ECO:0000305}.
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DR EMBL; AK041985; BAC31122.1; -; mRNA.
DR EMBL; AK077178; BAC36664.1; -; mRNA.
DR EMBL; AK078264; BAC37196.1; -; mRNA.
DR EMBL; BC062956; AAH62956.1; -; mRNA.
DR CCDS; CCDS30089.1; -. [Q8BHW5-1]
DR CCDS; CCDS72367.1; -. [Q8BHW5-2]
DR CCDS; CCDS81122.1; -. [Q8BHW5-3]
DR RefSeq; NP_001276656.1; NM_001289727.1. [Q8BHW5-3]
DR RefSeq; NP_001276657.1; NM_001289728.1. [Q8BHW5-2]
DR RefSeq; NP_766518.3; NM_172930.4. [Q8BHW5-1]
DR AlphaFoldDB; Q8BHW5; -.
DR STRING; 10090.ENSMUSP00000064511; -.
DR iPTMnet; Q8BHW5; -.
DR PhosphoSitePlus; Q8BHW5; -.
DR PaxDb; Q8BHW5; -.
DR PRIDE; Q8BHW5; -.
DR ProteomicsDB; 254633; -. [Q8BHW5-1]
DR ProteomicsDB; 254634; -. [Q8BHW5-2]
DR ProteomicsDB; 254635; -. [Q8BHW5-3]
DR Antibodypedia; 29876; 92 antibodies from 18 providers.
DR Ensembl; ENSMUST00000066498; ENSMUSP00000064511; ENSMUSG00000036502. [Q8BHW5-1]
DR Ensembl; ENSMUST00000089054; ENSMUSP00000086455; ENSMUSG00000036502. [Q8BHW5-2]
DR Ensembl; ENSMUST00000089056; ENSMUSP00000086457; ENSMUSG00000036502. [Q8BHW5-3]
DR GeneID; 245386; -.
DR KEGG; mmu:245386; -.
DR UCSC; uc009szr.3; mouse. [Q8BHW5-1]
DR UCSC; uc009szs.3; mouse. [Q8BHW5-2]
DR UCSC; uc033jpk.1; mouse. [Q8BHW5-3]
DR CTD; 55026; -.
DR MGI; MGI:3045722; Tmem255a.
DR VEuPathDB; HostDB:ENSMUSG00000036502; -.
DR eggNOG; ENOG502QVX8; Eukaryota.
DR GeneTree; ENSGT00940000160471; -.
DR HOGENOM; CLU_068698_1_0_1; -.
DR InParanoid; Q8BHW5; -.
DR OMA; MWASNAP; -.
DR PhylomeDB; Q8BHW5; -.
DR TreeFam; TF331034; -.
DR BioGRID-ORCS; 245386; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q8BHW5; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8BHW5; protein.
DR Bgee; ENSMUSG00000036502; Expressed in substantia nigra and 194 other tissues.
DR Genevisible; Q8BHW5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009617; P:response to bacterium; IEP:MGI.
DR InterPro; IPR028014; TMEM255.
DR PANTHER; PTHR33721; PTHR33721; 1.
DR Pfam; PF14967; FAM70; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..351
FT /note="Transmembrane protein 255A"
FT /id="PRO_0000266039"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 302..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 119..141
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021922"
FT VAR_SEQ 298..351
FT /note="HSGVFPSSPPSGLSDEQEPQSPSPSPSYMWSSSAPPRYSPPYYPPFEKPPPY
FT SP -> VFSWCVEKYSRHSKTTGNANLLLTAMVQETMGRA (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021923"
FT CONFLICT 49
FT /note="A -> T (in Ref. 1; BAC37196)"
FT /evidence="ECO:0000305"
FT CONFLICT 321
FT /note="P -> R (in Ref. 2; AAH62956)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 351 AA; 38633 MW; C6B3F7AFBAFAC52E CRC64;
MHQSLTQQRS SDMSLPDSMG AFNRRKRNSI YVTVTLLIVS MLILTVGLAA TTRTQNVTVG
GYYPGVILGF GSFLGIIGSN LIENKRQMLV ASIVFISFGV IAAFCCAIVD GVFAARHIDL
KPLYANRCHY VPKTSQREAE EVITSSSKIT PSTRALRNLT QAVKEVNCPQ LSRGLCTPRI
RGNTCFCCDL YNCGNRVEIT GGYYEYIDVS SCQDIIHLYH LLWSATILNI VGLFLGIITA
AVLGGFKDMN PTLPALNCSV ENAHPTVSYY ARPQVASYNT YYHSPPHLPP YSAYDFQHSG
VFPSSPPSGL SDEQEPQSPS PSPSYMWSSS APPRYSPPYY PPFEKPPPYS P
