T255B_HUMAN
ID T255B_HUMAN Reviewed; 326 AA.
AC Q8WV15;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Transmembrane protein 255B;
DE AltName: Full=Protein FAM70B;
GN Name=TMEM255B; Synonyms=FAM70B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8WV15; P53365: ARFIP2; NbExp=3; IntAct=EBI-2870087, EBI-638194;
CC Q8WV15; Q6ZPD8: DGAT2L6; NbExp=3; IntAct=EBI-2870087, EBI-12831978;
CC Q8WV15; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-2870087, EBI-18053395;
CC Q8WV15; Q8WV19: SFT2D1; NbExp=3; IntAct=EBI-2870087, EBI-2854842;
CC Q8WV15; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-2870087, EBI-8638294;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM255 family. {ECO:0000305}.
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DR EMBL; BX072579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX088578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC018995; AAH18995.1; -; mRNA.
DR CCDS; CCDS45071.1; -.
DR RefSeq; NP_872420.1; NM_182614.3.
DR AlphaFoldDB; Q8WV15; -.
DR BioGRID; 131501; 19.
DR IntAct; Q8WV15; 8.
DR STRING; 9606.ENSP00000364502; -.
DR TCDB; 9.B.200.1.2; the 4 tms tmem255 or pfam fam70 (tmem255) family.
DR iPTMnet; Q8WV15; -.
DR PhosphoSitePlus; Q8WV15; -.
DR BioMuta; TMEM255B; -.
DR DMDM; 74751534; -.
DR MassIVE; Q8WV15; -.
DR MaxQB; Q8WV15; -.
DR PaxDb; Q8WV15; -.
DR PeptideAtlas; Q8WV15; -.
DR PRIDE; Q8WV15; -.
DR ProteomicsDB; 74733; -.
DR Antibodypedia; 48950; 41 antibodies from 13 providers.
DR DNASU; 348013; -.
DR Ensembl; ENST00000375353.5; ENSP00000364502.3; ENSG00000184497.13.
DR GeneID; 348013; -.
DR KEGG; hsa:348013; -.
DR MANE-Select; ENST00000375353.5; ENSP00000364502.3; NM_182614.4; NP_872420.1.
DR UCSC; uc001vuh.4; human.
DR CTD; 348013; -.
DR DisGeNET; 348013; -.
DR GeneCards; TMEM255B; -.
DR HGNC; HGNC:28297; TMEM255B.
DR HPA; ENSG00000184497; Low tissue specificity.
DR neXtProt; NX_Q8WV15; -.
DR OpenTargets; ENSG00000184497; -.
DR PharmGKB; PA142671886; -.
DR VEuPathDB; HostDB:ENSG00000184497; -.
DR eggNOG; ENOG502QWXU; Eukaryota.
DR GeneTree; ENSGT00940000160889; -.
DR HOGENOM; CLU_068698_1_0_1; -.
DR InParanoid; Q8WV15; -.
DR OMA; YPIPMQH; -.
DR OrthoDB; 1106120at2759; -.
DR PhylomeDB; Q8WV15; -.
DR TreeFam; TF331034; -.
DR PathwayCommons; Q8WV15; -.
DR SignaLink; Q8WV15; -.
DR BioGRID-ORCS; 348013; 14 hits in 1070 CRISPR screens.
DR ChiTaRS; TMEM255B; human.
DR GenomeRNAi; 348013; -.
DR Pharos; Q8WV15; Tdark.
DR PRO; PR:Q8WV15; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q8WV15; protein.
DR Bgee; ENSG00000184497; Expressed in omental fat pad and 118 other tissues.
DR ExpressionAtlas; Q8WV15; baseline and differential.
DR Genevisible; Q8WV15; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028014; TMEM255.
DR PANTHER; PTHR33721; PTHR33721; 1.
DR Pfam; PF14967; FAM70; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..326
FT /note="Transmembrane protein 255B"
FT /id="PRO_0000266042"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 284..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..326
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 326 AA; 34609 MW; 3F40820C29E434AC CRC64;
MQPPVPGPLG LLDPAEGLSR RKKTSLWFVG SLLLVSVLIV TVGLAATTRT ENVTVGGYYP
GIILGFGSFL GIIGINLVEN RRQMLVAAIV FISFGVVAAF CCAIVDGVFA AQHIEPRPLT
TGRCQFYSSG VGYLYDVYQT EVTCHSLDGK CQLKVRSNTC YCCDLYACGS AEPSPAYYEF
IGVSGCQDVL HLYRLLWASA VLNVLGLFLG IITAAVLGAF KDMVPLSQLA YGPAVPPQTL
YNPAQQILAY AGFRLTPEPV PTCSSYPLPL QPCSRFPVAP SSALASSEDL QPPSPSSSGS
GLPGQAPPCY APTYFPPGEK PPPYAP
