ID   T255B_MOUSE             Reviewed;         369 AA.
AC   Q5FW56;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 3.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Transmembrane protein 255B;
DE   AltName: Full=Protein FAM70B;
GN   Name=Tmem255b; Synonyms=Fam70b, Gm687;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-369.
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM255 family. {ECO:0000305}.
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DR   EMBL; AC130818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC089620; AAH89620.1; -; mRNA.
DR   RefSeq; NP_001137143.1; NM_001143671.1.
DR   RefSeq; NP_001137144.1; NM_001143672.1.
DR   AlphaFoldDB; Q5FW56; -.
DR   STRING; 10090.ENSMUSP00000130504; -.
DR   PhosphoSitePlus; Q5FW56; -.
DR   PaxDb; Q5FW56; -.
DR   PRIDE; Q5FW56; -.
DR   ProteomicsDB; 263235; -.
DR   GeneID; 272465; -.
DR   KEGG; mmu:272465; -.
DR   CTD; 348013; -.
DR   MGI; MGI:2685533; Tmem255b.
DR   eggNOG; ENOG502QWXU; Eukaryota.
DR   InParanoid; Q5FW56; -.
DR   OrthoDB; 1106120at2759; -.
DR   BioGRID-ORCS; 272465; 1 hit in 73 CRISPR screens.
DR   ChiTaRS; Tmem255b; mouse.
DR   PRO; PR:Q5FW56; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q5FW56; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR028014; TMEM255.
DR   PANTHER; PTHR33721; PTHR33721; 1.
DR   Pfam; PF14967; FAM70; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..369
FT                   /note="Transmembrane protein 255B"
FT                   /id="PRO_0000266043"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          318..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        318..348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        130..132
FT                   /note="AAS -> GAA (in Ref. 2; AAH89620)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   369 AA;  39392 MW;  E5B3AF4BDD3894B3 CRC64;
     MVGAEGRWRE KGNDQRRGRK KRGGVEESGH RAAFLETAGT LKPNHRAGGA SGHCPPSGGH
     FGNAAAPTAR ARPSGSAGHH RGLCQEEEDL SVVCGLSPAG VYSHPDHWPC CNHQDRECDC
     GRLLPRDYFA ASIVFLSFGV VAAFCCAIVD SVFAARHIEP RPLSAGRCQF YSSGAGYLYD
     VYQTEVTCYS LNGRCQLKVR SNTCYCCDLY ACGSTEPSPA YYEFVGVRSC QDVVHLYRLL
     WVSTVLNVLG LCLGIVTAAV LGAFKDMVPL SQLAYGPSPP PQILYNPAQQ ILAYTGLCPP
     SMGVPTCSSY PLPLQPSSAP PASASADLSL PEDTESPSQC QPSRGCSHAP SPCTPAYFLP
     GEKPPPYAP