T257_STAAU
ID T257_STAAU Reviewed; 224 AA.
AC P14506; Q99374;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Transposase for insertion sequence element IS257 in transposon Tn4003;
OS Staphylococcus aureus.
OG Plasmid pSK1, Plasmid pABU1, and Plasmid pUB101.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1280;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC PLASMID=pSK1; TRANSPOSON=Tn4003;
RX PubMed=2548057; DOI=10.1111/j.1365-2958.1989.tb01805.x;
RA Rouch D.A., Messeroti L.J., Loo L.S.L., Jackson C.A., Skurray R.A.;
RT "Trimethoprim resistance transposon Tn4003 from Staphylococcus aureus
RT encodes genes for a dihydrofolate reductase and thymidylate synthetase
RT flanked by three copies of IS257.";
RL Mol. Microbiol. 3:161-175(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 209-224.
RC STRAIN=157/4696; PLASMID=pABU1;
RX PubMed=2365064; DOI=10.1016/0014-5793(90)81529-w;
RA Burdeska A., Ott M., Bannwarth W., Then R.L.;
RT "Identical genes for trimethoprim-resistant dihydrofolate reductase from
RT Staphylococcus aureus in Australia and central Europe.";
RL FEBS Lett. 266:159-162(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 209-224.
RC PLASMID=pUB101;
RA O'Neill A.J., Chopra I.;
RT "Cloning and sequencing of fusB, a plasmid-encoded fusidic acid-resistance
RT determinant.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the transposition of the insertion sequence.
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DR EMBL; X13290; CAA31652.1; -; Genomic_DNA.
DR EMBL; X13290; CAA31647.1; -; Genomic_DNA.
DR EMBL; Y07536; CAA68826.1; -; Genomic_DNA.
DR EMBL; AY047358; AAL12237.1; -; Genomic_DNA.
DR PIR; S04162; S04162.
DR RefSeq; NP_863622.1; NC_005024.1.
DR RefSeq; NP_877985.1; NC_005054.1.
DR RefSeq; WP_001106019.1; NZ_WKHE01000090.1.
DR RefSeq; YP_002790917.1; NC_012547.1.
DR RefSeq; YP_002790945.1; NC_012547.1.
DR RefSeq; YP_003813113.1; NC_014369.1.
DR RefSeq; YP_003813118.1; NC_014369.1.
DR RefSeq; YP_006937650.1; NC_013320.1.
DR RefSeq; YP_006937664.1; NC_013320.1.
DR RefSeq; YP_006937706.1; NC_013321.1.
DR RefSeq; YP_006938352.1; NC_013338.1.
DR RefSeq; YP_006938378.1; NC_013339.1.
DR RefSeq; YP_006938493.1; NC_013342.1.
DR RefSeq; YP_006938519.1; NC_013343.1.
DR RefSeq; YP_006938580.1; NC_013344.1.
DR AlphaFoldDB; P14506; -.
DR SMR; P14506; -.
DR OMA; THETVRC; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR032874; DDE_dom.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR Pfam; PF13610; DDE_Tnp_IS240; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 4: Predicted;
KW DNA recombination; DNA-binding; Plasmid; Transposable element;
KW Transposition.
FT CHAIN 1..224
FT /note="Transposase for insertion sequence element IS257 in
FT transposon Tn4003"
FT /id="PRO_0000075435"
FT DOMAIN 73..222
FT /note="Integrase catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
FT DNA_BIND 33..52
FT /note="H-T-H motif"
FT /evidence="ECO:0000255"
SQ SEQUENCE 224 AA; 26813 MW; 43FEEB10C9BB21BE CRC64;
MNYFRYKQFN KDVITVAVGY YLRYALSYRD ISEILRGRGV NVHHSTVYRW VQEYAPILYQ
IWKKKHKKAY YKWRIDETYI KIKGKWSYLY RAIDAEGHTL DIWLRKQRDN HSAYAFIKRL
IKQFGKPQKV ITDQAPSTKV AMAKVIKAFK LKPDCHCTSK YLNNLIEQDH RHIKVRKTRY
QSINTAKNTL KGIECIYALY KKNRRSLQIY GFSPCHEISI MLAS
