BPC5_ARATH
ID BPC5_ARATH Reviewed; 283 AA.
AC F4JUI3; E6Y2M5; E6Y2M6; F4JUI4; Q9SVK1;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Protein BASIC PENTACYSTEINE5;
DE Short=AtBPC5;
DE AltName: Full=GAGA-motif binding transcriptional activator BBR/BPC5;
GN Name=BPC5; Synonyms=BBR/BPC5; OrderedLocusNames=At4g38910;
GN ORFNames=F19H22.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RC STRAIN=cv. Ak-1, and cv. Bay-0;
RX PubMed=12795701; DOI=10.1046/j.1365-313x.2003.01767.x;
RA Santi L., Wang Y., Stile M.R., Berendzen K.W., Wanke D., Roig C., Pozzi C.,
RA Mueller K., Mueller J., Rohde W., Salamini F.;
RT "The GA octodinucleotide repeat binding factor BBR participates in the
RT transcriptional regulation of the homeobox gene Bkn3.";
RL Plant J. 34:813-826(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, DNA-BINDING, AND TISSUE
RP SPECIFICITY.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=14731261; DOI=10.1046/j.1365-313x.2003.01971.x;
RA Meister R.J., Williams L.A., Monfared M.M., Gallagher T.L., Kraft E.A.,
RA Nelson C.G., Gasser C.S.;
RT "Definition and interactions of a positive regulatory element of the
RT Arabidopsis INNER NO OUTER promoter.";
RL Plant J. 37:426-438(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [6]
RP GENE FAMILY.
RA Bloss U., Hohenstatt M.L., Hummel S., Harter K., Wanke D.;
RT "The plant specific BPC/BBR family of GAGA-repeat binding proteins.";
RL (In) Proceedings of the 20th international conference on Arabidopsis
RL research, abstract#084, Edinburgh (2009).
CC -!- FUNCTION: Transcriptional regulator that specifically binds to GA-rich
CC elements (GAGA-repeats) present in regulatory sequences of genes
CC involved in developmental processes. {ECO:0000269|PubMed:14731261}.
CC -!- SUBUNIT: Homodimer. Heterodimer. {ECO:0000250}.
CC -!- INTERACTION:
CC F4JUI3; Q8L999-2: BPC6; NbExp=3; IntAct=EBI-15194873, EBI-15196639;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F4JUI3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4JUI3-2; Sequence=VSP_041899;
CC -!- TISSUE SPECIFICITY: Expressed in seedlings, leaves and pistils.
CC {ECO:0000269|PubMed:14731261}.
CC -!- DOMAIN: Alanine-zipper domain is involved in homo- or hetero-
CC dimerization via electrostatic interaction.
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice
CC site. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the BBR/BPC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABU63289.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=ABU63290.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAB38811.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80554.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; EF633604; ABU63289.1; ALT_INIT; Genomic_DNA.
DR EMBL; EF633605; ABU63290.1; ALT_INIT; Genomic_DNA.
DR EMBL; AY380571; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL035679; CAB38811.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161594; CAB80554.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE86991.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE86992.1; -; Genomic_DNA.
DR EMBL; BX827792; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; T06051; T06051.
DR RefSeq; NP_001190957.1; NM_001204028.2. [F4JUI3-1]
DR RefSeq; NP_195602.5; NM_120051.6. [F4JUI3-2]
DR AlphaFoldDB; F4JUI3; -.
DR SMR; F4JUI3; -.
DR BioGRID; 15326; 7.
DR IntAct; F4JUI3; 7.
DR STRING; 3702.AT4G38910.2; -.
DR PaxDb; F4JUI3; -.
DR PRIDE; F4JUI3; -.
DR ProteomicsDB; 240807; -. [F4JUI3-1]
DR EnsemblPlants; AT4G38910.1; AT4G38910.1; AT4G38910. [F4JUI3-2]
DR EnsemblPlants; AT4G38910.2; AT4G38910.2; AT4G38910. [F4JUI3-1]
DR GeneID; 830046; -.
DR Gramene; AT4G38910.1; AT4G38910.1; AT4G38910. [F4JUI3-2]
DR Gramene; AT4G38910.2; AT4G38910.2; AT4G38910. [F4JUI3-1]
DR KEGG; ath:AT4G38910; -.
DR Araport; AT4G38910; -.
DR TAIR; locus:2120227; AT4G38910.
DR eggNOG; ENOG502R48X; Eukaryota.
DR InParanoid; F4JUI3; -.
DR OMA; RCQGADD; -.
DR OrthoDB; 1076395at2759; -.
DR PRO; PR:F4JUI3; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JUI3; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009723; P:response to ethylene; IBA:GO_Central.
DR InterPro; IPR010409; GAGA-bd_tscrpt_act.
DR PANTHER; PTHR31421; PTHR31421; 1.
DR Pfam; PF06217; GAGA_bind; 1.
DR SMART; SM01226; GAGA_bind; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..283
FT /note="Protein BASIC PENTACYSTEINE5"
FT /id="PRO_0000413439"
FT REGION 51..86
FT /note="Alanine-zipper"
FT REGION 122..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 63..89
FT /evidence="ECO:0000255"
FT COMPBIAS 122..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..25
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14731261,
FT ECO:0000303|PubMed:14993207"
FT /id="VSP_041899"
FT VARIANT 114
FT /note="G -> D (in strain: cv. Ak-1)"
FT VARIANT 188
FT /note="M -> T (in strain: cv. Ak-1; cv. Bay-0 and cv.
FT Landsberg erecta)"
FT VARIANT 196
FT /note="T -> A (in strain: cv. Bay-0)"
FT CONFLICT 29
FT /note="K -> E (in Ref. 5; BX827792)"
FT /evidence="ECO:0000305"
FT CONFLICT 204
FT /note="C -> F (in Ref. 5; BX827792)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 283 AA; 31776 MW; 8B877DB078BD3030 CRC64;
MESGGQYENG RYKPDYYKGT QSVNVMPKKE QHNALVMNKK IISILAERDA AVKERNEAVA
ATKEALASRD EALEQRDKAL SERDNAIMET ESALNALRYR ENNLNYILSC AKRGGSQRFI
TEESHLPNPS PISTIPPEAA NTRPTKRKKE SKQGKKMGED LNRPVASPGK KSRKDWDSND
VLVTFDEMTM PVPMCTCTGT ARQCYKWGNG GWQSSCCTTT LSEYPLPQMP NKRHSRVGGR
KMSGSVFSRL LSRLAGEGHE LSSPVDLKNY WARHGTNRYI TIK
