ID   T2AG_CAEEL              Reviewed;         113 AA.
AC   Q9NEX2;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 2.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Transcription initiation factor IIA subunit 2;
DE   AltName: Full=General transcription factor IIA subunit 2;
DE   AltName: Full=Transcription initiation factor IIA gamma chain;
DE            Short=TFIIA-gamma;
GN   Name=gtf-2A2 {ECO:0000312|WormBase:Y111B2A.13};
GN   ORFNames=Y111B2A.13 {ECO:0000312|WormBase:Y111B2A.13};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: TFIIA is a component of the transcription machinery of RNA
CC       polymerase II and plays an important role in transcriptional
CC       activation. TFIIA in a complex with TBP mediates transcriptional
CC       activity. {ECO:0000250|UniProtKB:P52657}.
CC   -!- SUBUNIT: TFIIA is a heterodimer of the large unprocessed subunit 1 and
CC       a small subunit gamma. It was originally believed to be a heterotrimer
CC       of an alpha, a beta and a gamma subunit.
CC       {ECO:0000250|UniProtKB:P52656}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P32774}.
CC   -!- SIMILARITY: Belongs to the TFIIA subunit 2 family. {ECO:0000305}.
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DR   EMBL; BX284603; CAC35842.1; -; Genomic_DNA.
DR   RefSeq; NP_499644.1; NM_067243.4.
DR   AlphaFoldDB; Q9NEX2; -.
DR   SMR; Q9NEX2; -.
DR   BioGRID; 41860; 3.
DR   STRING; 6239.Y111B2A.13; -.
DR   PaxDb; Q9NEX2; -.
DR   PeptideAtlas; Q9NEX2; -.
DR   EnsemblMetazoa; Y111B2A.13.1; Y111B2A.13.1; WBGene00013736.
DR   GeneID; 176682; -.
DR   KEGG; cel:CELE_Y111B2A.13; -.
DR   UCSC; Y111B2A.13; c. elegans.
DR   CTD; 176682; -.
DR   WormBase; Y111B2A.13; CE26630; WBGene00013736; gtf-2A2.
DR   eggNOG; KOG3463; Eukaryota.
DR   GeneTree; ENSGT00390000014572; -.
DR   HOGENOM; CLU_112964_3_1_1; -.
DR   InParanoid; Q9NEX2; -.
DR   OMA; RAYRYCD; -.
DR   OrthoDB; 1589933at2759; -.
DR   PhylomeDB; Q9NEX2; -.
DR   Reactome; R-CEL-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-CEL-6807505; RNA polymerase II transcribes snRNA genes.
DR   Reactome; R-CEL-73776; RNA Polymerase II Promoter Escape.
DR   Reactome; R-CEL-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR   Reactome; R-CEL-75953; RNA Polymerase II Transcription Initiation.
DR   Reactome; R-CEL-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR   Reactome; R-CEL-9018519; Estrogen-dependent gene expression.
DR   PRO; PR:Q9NEX2; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00013736; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0005672; C:transcription factor TFIIA complex; IBA:GO_Central.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0017025; F:TBP-class protein binding; IBA:GO_Central.
DR   GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IBA:GO_Central.
DR   CDD; cd10014; TFIIA_gamma_C; 1.
DR   CDD; cd10145; TFIIA_gamma_N; 1.
DR   Gene3D; 1.10.287.190; -; 1.
DR   Gene3D; 2.30.18.10; -; 1.
DR   InterPro; IPR009083; TFIIA_a-hlx.
DR   InterPro; IPR009088; TFIIA_b-brl.
DR   InterPro; IPR003194; TFIIA_gsu.
DR   InterPro; IPR015871; TFIIA_gsu_C.
DR   InterPro; IPR015872; TFIIA_gsu_N.
DR   PANTHER; PTHR10966; PTHR10966; 1.
DR   Pfam; PF02751; TFIIA_gamma_C; 1.
DR   Pfam; PF02268; TFIIA_gamma_N; 1.
DR   PIRSF; PIRSF009415; Hum_TFIIA_gamma; 1.
DR   SUPFAM; SSF50784; SSF50784; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..113
FT                   /note="Transcription initiation factor IIA subunit 2"
FT                   /id="PRO_0000194047"
SQ   SEQUENCE   113 AA;  12906 MW;  601A6DF9E5FB4206 CRC64;
     MEKPNYQLYR NTTLGQALQK TLDDFVGDQM IPDSLSKKIM DSFDKSINKI LPHKAKNKVN
     FRADKLRAYR YCDNVWTFIV EQIDLRDAVE GGTVDRLKIV ACDGQTKGQI GHA