ID   T2AG_IXOSC              Reviewed;         118 AA.
AC   B7Q1Q9;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Transcription initiation factor IIA subunit 2;
DE   AltName: Full=General transcription factor IIA subunit 2;
DE   AltName: Full=Transcription initiation factor IIA gamma chain;
DE            Short=TFIIA-gamma;
GN   ORFNames=IscW_ISCW010050;
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wikel;
RG   Ixodes scapularis Genome Project Consortium;
RA   Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA   Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA   Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA   Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT   "Annotation of Ixodes scapularis.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: TFIIA is a component of the transcription machinery of RNA
CC       polymerase II and plays an important role in transcriptional
CC       activation. TFIIA in a complex with Tbp mediates transcriptional
CC       activity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: TFIIA is a heterodimer of the large unprocessed subunit 1 and
CC       a small subunit gamma. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFIIA subunit 2 family. {ECO:0000305}.
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DR   EMBL; DS839047; EEC12781.1; -; Genomic_DNA.
DR   RefSeq; XP_002410024.1; XM_002409980.1.
DR   AlphaFoldDB; B7Q1Q9; -.
DR   SMR; B7Q1Q9; -.
DR   STRING; 6945.B7Q1Q9; -.
DR   KEGG; isc:IscW_ISCW010050; -.
DR   VEuPathDB; VectorBase:ISCI010050; -.
DR   VEuPathDB; VectorBase:ISCW010050; -.
DR   HOGENOM; CLU_112964_3_1_1; -.
DR   InParanoid; B7Q1Q9; -.
DR   OMA; FREVHEI; -.
DR   OrthoDB; 1589933at2759; -.
DR   PhylomeDB; B7Q1Q9; -.
DR   Proteomes; UP000001555; Unassembled WGS sequence.
DR   GO; GO:0005672; C:transcription factor TFIIA complex; IBA:GO_Central.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0017025; F:TBP-class protein binding; IBA:GO_Central.
DR   GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IBA:GO_Central.
DR   CDD; cd10014; TFIIA_gamma_C; 1.
DR   CDD; cd10145; TFIIA_gamma_N; 1.
DR   Gene3D; 1.10.287.190; -; 1.
DR   Gene3D; 2.30.18.10; -; 1.
DR   InterPro; IPR009083; TFIIA_a-hlx.
DR   InterPro; IPR009088; TFIIA_b-brl.
DR   InterPro; IPR003194; TFIIA_gsu.
DR   InterPro; IPR015871; TFIIA_gsu_C.
DR   InterPro; IPR015872; TFIIA_gsu_N.
DR   PANTHER; PTHR10966; PTHR10966; 1.
DR   Pfam; PF02751; TFIIA_gamma_C; 1.
DR   Pfam; PF02268; TFIIA_gamma_N; 1.
DR   PIRSF; PIRSF009415; Hum_TFIIA_gamma; 1.
DR   SUPFAM; SSF50784; SSF50784; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..118
FT                   /note="Transcription initiation factor IIA subunit 2"
FT                   /id="PRO_0000406206"
SQ   SEQUENCE   118 AA;  13528 MW;  572B5D8CF2DA9C8F CRC64;
     MSYQLYRNTT LGNTLQESLD ELIQCGQITP HLALKVLLQF DKAINNALAN RVKTRLTFKA
     GHLSTYRFCD NVWTFVLKDV EFREVQELVK ADKVKIVACD GKSVLFFLFS SLFSLYGK