T2AG_MOUSE
ID T2AG_MOUSE Reviewed; 109 AA.
AC Q80ZM7;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Transcription initiation factor IIA subunit 2;
DE AltName: Full=General transcription factor IIA subunit 2;
DE AltName: Full=Transcription initiation factor IIA gamma chain;
DE Short=TFIIA-gamma;
GN Name=Gtf2a2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:AAH48705.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Limb {ECO:0000312|EMBL:AAH48705.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: TFIIA is a component of the transcription machinery of RNA
CC polymerase II and plays an important role in transcriptional
CC activation. TFIIA in a complex with TBP mediates transcriptional
CC activity (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: TFIIA is a heterodimer of the large unprocessed subunit 1 and
CC a small subunit gamma. It was originally believed to be a heterotrimer
CC of an alpha (p35), a beta (p19) and a gamma subunit (p12). Interacts
CC with NCOA6 general coactivator. TFIIA forms a complex with TBP.
CC Interacts with HSF1 (via transactivation domain). Interacts with HSF1
CC (via transactivation domain). Interacts with HSF1 (via transactivation
CC domain). {ECO:0000250|UniProtKB:P52656, ECO:0000250|UniProtKB:P52657}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TFIIA subunit 2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH48705.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; BC048705; AAH48705.1; ALT_SEQ; mRNA.
DR CCDS; CCDS52851.1; -.
DR RefSeq; NP_001034608.1; NM_001039519.2.
DR RefSeq; NP_001269012.1; NM_001282083.1.
DR RefSeq; XP_006511179.1; XM_006511116.2.
DR AlphaFoldDB; Q80ZM7; -.
DR SMR; Q80ZM7; -.
DR BioGRID; 231665; 2.
DR ComplexPortal; CPX-743; Transcription factor complex TFIIA.
DR STRING; 10090.ENSMUSP00000113501; -.
DR iPTMnet; Q80ZM7; -.
DR PhosphoSitePlus; Q80ZM7; -.
DR MaxQB; Q80ZM7; -.
DR PaxDb; Q80ZM7; -.
DR PRIDE; Q80ZM7; -.
DR ProteomicsDB; 263236; -.
DR Antibodypedia; 25406; 103 antibodies from 21 providers.
DR Ensembl; ENSMUST00000118198; ENSMUSP00000113501; ENSMUSG00000033543.
DR Ensembl; ENSMUST00000119413; ENSMUSP00000113697; ENSMUSG00000033543.
DR GeneID; 235459; -.
DR KEGG; mmu:235459; -.
DR UCSC; uc009qnr.2; mouse.
DR CTD; 2958; -.
DR MGI; MGI:1933289; Gtf2a2.
DR VEuPathDB; HostDB:ENSMUSG00000033543; -.
DR eggNOG; KOG3463; Eukaryota.
DR GeneTree; ENSGT00390000014572; -.
DR InParanoid; Q80ZM7; -.
DR OMA; QYYELYR; -.
DR OrthoDB; 1589933at2759; -.
DR PhylomeDB; Q80ZM7; -.
DR TreeFam; TF315131; -.
DR Reactome; R-MMU-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-MMU-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-MMU-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-MMU-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-MMU-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-MMU-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR Reactome; R-MMU-9018519; Estrogen-dependent gene expression.
DR BioGRID-ORCS; 235459; 24 hits in 67 CRISPR screens.
DR ChiTaRS; Gtf2a2; mouse.
DR PRO; PR:Q80ZM7; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q80ZM7; protein.
DR Bgee; ENSMUSG00000033543; Expressed in atrioventricular valve and 247 other tissues.
DR ExpressionAtlas; Q80ZM7; baseline and differential.
DR Genevisible; Q80ZM7; MM.
DR GO; GO:0030054; C:cell junction; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005672; C:transcription factor TFIIA complex; ISO:MGI.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISO:MGI.
DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; ISO:MGI.
DR GO; GO:0001091; F:RNA polymerase II general transcription initiation factor binding; ISO:MGI.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IPI:MGI.
DR GO; GO:0017025; F:TBP-class protein binding; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; ISO:MGI.
DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; ISO:MGI.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISO:MGI.
DR CDD; cd10014; TFIIA_gamma_C; 1.
DR CDD; cd10145; TFIIA_gamma_N; 1.
DR Gene3D; 1.10.287.190; -; 1.
DR Gene3D; 2.30.18.10; -; 1.
DR InterPro; IPR009083; TFIIA_a-hlx.
DR InterPro; IPR009088; TFIIA_b-brl.
DR InterPro; IPR003194; TFIIA_gsu.
DR InterPro; IPR015871; TFIIA_gsu_C.
DR InterPro; IPR015872; TFIIA_gsu_N.
DR PANTHER; PTHR10966; PTHR10966; 1.
DR Pfam; PF02751; TFIIA_gamma_C; 1.
DR Pfam; PF02268; TFIIA_gamma_N; 1.
DR PIRSF; PIRSF009415; Hum_TFIIA_gamma; 1.
DR SUPFAM; SSF50784; SSF50784; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..109
FT /note="Transcription initiation factor IIA subunit 2"
FT /id="PRO_0000194043"
SQ SEQUENCE 109 AA; 12473 MW; 8BEE65B0D9982AFA CRC64;
MAYQLYRNTT LGNSLQESLD ELIQSQQITP QLALQVLLQF DKAINSALAQ RVRNRVNFRG
SLNTYRFCDN VWTFVLNDVE FREVTELIKV DKVKIVACDG KNTGSNTTE
