T2AG_RAT
ID T2AG_RAT Reviewed; 109 AA.
AC O08950;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Transcription initiation factor IIA subunit 2;
DE AltName: Full=General transcription factor IIA subunit 2;
DE AltName: Full=Transcription initiation factor IIA gamma chain;
DE Short=TFIIA-gamma;
GN Name=Gtf2a2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RA Upadhyaya A.B., Dejong J.;
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: TFIIA is a component of the transcription machinery of RNA
CC polymerase II and plays an important role in transcriptional
CC activation. TFIIA in a complex with TBP mediates transcriptional
CC activity (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: TFIIA is a heterodimer of the large unprocessed subunit 1 and
CC a small subunit gamma. It was originally believed to be a heterotrimer
CC of an alpha (p35), a beta (p19) and a gamma subunit (p12). Interacts
CC with NCOA6 general coactivator. TFIIA forms a complex with TBP.
CC Interacts with HSF1 (via transactivation domain). Interacts with HSF1
CC (via transactivation domain). Interacts with HSF1 (via transactivation
CC domain). {ECO:0000250|UniProtKB:P52656, ECO:0000250|UniProtKB:P52657}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the TFIIA subunit 2 family. {ECO:0000305}.
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DR EMBL; AF000944; AAB58717.1; -; mRNA.
DR RefSeq; NP_445797.1; NM_053345.1.
DR RefSeq; XP_006243442.1; XM_006243380.3.
DR RefSeq; XP_008773362.1; XM_008775140.2.
DR AlphaFoldDB; O08950; -.
DR SMR; O08950; -.
DR STRING; 10116.ENSRNOP00000014706; -.
DR PhosphoSitePlus; O08950; -.
DR PaxDb; O08950; -.
DR Ensembl; ENSRNOT00000085496; ENSRNOP00000068825; ENSRNOG00000056701.
DR GeneID; 83828; -.
DR KEGG; rno:83828; -.
DR UCSC; RGD:620720; rat.
DR CTD; 2958; -.
DR RGD; 620720; Gtf2a2.
DR eggNOG; KOG3463; Eukaryota.
DR GeneTree; ENSGT00390000014572; -.
DR HOGENOM; CLU_112964_2_1_1; -.
DR InParanoid; O08950; -.
DR OMA; QYYELYR; -.
DR OrthoDB; 1589933at2759; -.
DR PhylomeDB; O08950; -.
DR TreeFam; TF315131; -.
DR Reactome; R-RNO-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-RNO-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-RNO-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-RNO-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-RNO-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-RNO-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR Reactome; R-RNO-9018519; Estrogen-dependent gene expression.
DR PRO; PR:O08950; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000056701; Expressed in ovary and 19 other tissues.
DR ExpressionAtlas; O08950; baseline and differential.
DR Genevisible; O08950; RN.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0005672; C:transcription factor TFIIA complex; ISO:RGD.
DR GO; GO:0005669; C:transcription factor TFIID complex; ISO:RGD.
DR GO; GO:0046982; F:protein heterodimerization activity; ISO:RGD.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; ISO:RGD.
DR GO; GO:0001091; F:RNA polymerase II general transcription initiation factor binding; ISO:RGD.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:RGD.
DR GO; GO:0017025; F:TBP-class protein binding; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:RGD.
DR GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; ISO:RGD.
DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; ISO:RGD.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISO:RGD.
DR CDD; cd10014; TFIIA_gamma_C; 1.
DR CDD; cd10145; TFIIA_gamma_N; 1.
DR Gene3D; 1.10.287.190; -; 1.
DR Gene3D; 2.30.18.10; -; 1.
DR InterPro; IPR009083; TFIIA_a-hlx.
DR InterPro; IPR009088; TFIIA_b-brl.
DR InterPro; IPR003194; TFIIA_gsu.
DR InterPro; IPR015871; TFIIA_gsu_C.
DR InterPro; IPR015872; TFIIA_gsu_N.
DR PANTHER; PTHR10966; PTHR10966; 1.
DR Pfam; PF02751; TFIIA_gamma_C; 1.
DR Pfam; PF02268; TFIIA_gamma_N; 1.
DR PIRSF; PIRSF009415; Hum_TFIIA_gamma; 1.
DR SUPFAM; SSF50784; SSF50784; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..109
FT /note="Transcription initiation factor IIA subunit 2"
FT /id="PRO_0000194044"
SQ SEQUENCE 109 AA; 12473 MW; 8BEE65B0D9982AFA CRC64;
MAYQLYRNTT LGNSLQESLD ELIQSQQITP QLALQVLLQF DKAINSALAQ RVRNRVNFRG
SLNTYRFCDN VWTFVLNDVE FREVTELIKV DKVKIVACDG KNTGSNTTE
