ID   T2AG_SCHMA              Reviewed;         104 AA.
AC   C4QGM3; G4VCY5;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2012, sequence version 2.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Transcription initiation factor IIA subunit 2;
DE   AltName: Full=General transcription factor IIA subunit 2;
DE   AltName: Full=Transcription initiation factor IIA gamma chain;
DE            Short=TFIIA-gamma;
GN   ORFNames=Smp_071830;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican;
RX   PubMed=19606141; DOI=10.1038/nature08160;
RA   Berriman M., Haas B.J., LoVerde P.T., Wilson R.A., Dillon G.P.,
RA   Cerqueira G.C., Mashiyama S.T., Al-Lazikani B., Andrade L.F., Ashton P.D.,
RA   Aslett M.A., Bartholomeu D.C., Blandin G., Caffrey C.R., Coghlan A.,
RA   Coulson R., Day T.A., Delcher A., DeMarco R., Djikeng A., Eyre T.,
RA   Gamble J.A., Ghedin E., Gu Y., Hertz-Fowler C., Hirai H., Hirai Y.,
RA   Houston R., Ivens A., Johnston D.A., Lacerda D., Macedo C.D., McVeigh P.,
RA   Ning Z., Oliveira G., Overington J.P., Parkhill J., Pertea M., Pierce R.J.,
RA   Protasio A.V., Quail M.A., Rajandream M.A., Rogers J., Sajid M.,
RA   Salzberg S.L., Stanke M., Tivey A.R., White O., Williams D.L., Wortman J.,
RA   Wu W., Zamanian M., Zerlotini A., Fraser-Liggett C.M., Barrell B.G.,
RA   El-Sayed N.M.;
RT   "The genome of the blood fluke Schistosoma mansoni.";
RL   Nature 460:352-358(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican;
RX   PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA   Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA   De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA   Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA   Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA   Zerlotini A., Dunne D.W., Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of the
RT   human blood fluke Schistosoma mansoni.";
RL   PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
CC   -!- FUNCTION: TFIIA is a component of the transcription machinery of RNA
CC       polymerase II and plays an important role in transcriptional
CC       activation. TFIIA in a complex with TBP mediates transcriptional
CC       activity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: TFIIA is a heterodimer of the large unprocessed subunit 1 and
CC       a small subunit gamma. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFIIA subunit 2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCD77760.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HE601625; CCD77760.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_018650380.1; XM_018796137.1.
DR   AlphaFoldDB; C4QGM3; -.
DR   SMR; C4QGM3; -.
DR   STRING; 6183.Smp_071830.1; -.
DR   GeneID; 8348851; -.
DR   KEGG; smm:Smp_071830; -.
DR   CTD; 8348851; -.
DR   eggNOG; KOG3463; Eukaryota.
DR   InParanoid; C4QGM3; -.
DR   OrthoDB; 1589933at2759; -.
DR   Proteomes; UP000008854; Chromosome 2.
DR   GO; GO:0005672; C:transcription factor TFIIA complex; IEA:InterPro.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:InterPro.
DR   CDD; cd10014; TFIIA_gamma_C; 1.
DR   CDD; cd10145; TFIIA_gamma_N; 1.
DR   Gene3D; 1.10.287.190; -; 1.
DR   Gene3D; 2.30.18.10; -; 1.
DR   InterPro; IPR009083; TFIIA_a-hlx.
DR   InterPro; IPR009088; TFIIA_b-brl.
DR   InterPro; IPR003194; TFIIA_gsu.
DR   InterPro; IPR015871; TFIIA_gsu_C.
DR   InterPro; IPR015872; TFIIA_gsu_N.
DR   PANTHER; PTHR10966; PTHR10966; 1.
DR   Pfam; PF02751; TFIIA_gamma_C; 1.
DR   Pfam; PF02268; TFIIA_gamma_N; 1.
DR   PIRSF; PIRSF009415; Hum_TFIIA_gamma; 1.
DR   SUPFAM; SSF50784; SSF50784; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..104
FT                   /note="Transcription initiation factor IIA subunit 2"
FT                   /id="PRO_0000406205"
SQ   SEQUENCE   104 AA;  11941 MW;  3CA9E2B374A7AF07 CRC64;
     MTYHEMYRST TLGTTLREAL DEMLAHNLLQ PGMDHKVMQK FDQCISNALA KRVKNRLSLR
     GHLNTYRNCD NVWTLVMNDV EIKDSSAIMT VDKVSLNSPL ICKI