BPH1_SCHPO
ID BPH1_SCHPO Reviewed; 2609 AA.
AC Q7LKZ7;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Beige protein homolog 1;
GN Name=lvs1; ORFNames=SPBC28E12.06c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: May be involved in protein sorting and cell wall formation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329671; CAA20653.2; -; Genomic_DNA.
DR RefSeq; NP_595759.2; NM_001021659.3.
DR AlphaFoldDB; Q7LKZ7; -.
DR SMR; Q7LKZ7; -.
DR BioGRID; 277098; 1.
DR STRING; 4896.SPBC28E12.06c.1; -.
DR iPTMnet; Q7LKZ7; -.
DR MaxQB; Q7LKZ7; -.
DR PaxDb; Q7LKZ7; -.
DR PRIDE; Q7LKZ7; -.
DR EnsemblFungi; SPBC28E12.06c.1; SPBC28E12.06c.1:pep; SPBC28E12.06c.
DR GeneID; 2540571; -.
DR KEGG; spo:SPBC28E12.06c; -.
DR PomBase; SPBC28E12.06c; lvs1.
DR VEuPathDB; FungiDB:SPBC28E12.06c; -.
DR eggNOG; KOG1786; Eukaryota.
DR HOGENOM; CLU_000175_2_0_1; -.
DR InParanoid; Q7LKZ7; -.
DR OMA; EMSNFHY; -.
DR PhylomeDB; Q7LKZ7; -.
DR PRO; PR:Q7LKZ7; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0000324; C:fungal-type vacuole; ISO:PomBase.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; ISM:PomBase.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0006914; P:autophagy; ISO:PomBase.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR GO; GO:0007033; P:vacuole organization; IGI:PomBase.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; -; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF49899; SSF49899; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR SUPFAM; SSF81837; SSF81837; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Membrane; Metal-binding; Reference proteome; Repeat; WD repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..2609
FT /note="Beige protein homolog 1"
FT /id="PRO_0000372305"
FT DOMAIN 1735..1870
FT /note="BEACH-type PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01119"
FT DOMAIN 1907..2202
FT /note="BEACH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00026"
FT REPEAT 2249..2290
FT /note="WD 1"
FT REPEAT 2294..2332
FT /note="WD 2"
FT REPEAT 2340..2379
FT /note="WD 3"
FT REPEAT 2429..2475
FT /note="WD 4"
FT REPEAT 2507..2546
FT /note="WD 5"
FT ZN_FING 2550..2604
FT /note="FYVE-type"
FT REGION 1654..1679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1691..1729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2609 AA; 295658 MW; 9E9624F739DB9227 CRC64;
MDRKANAYSK SVELLSRLEG CPSEKVLLEE LRKLRGFIRN DIPSNFFPQL FITDNGFAAI
KKAVTKLNFQ SLLSLDIFEC CLQILGIATS YTILRSWLLS RKHIEAWIEL AIRRMFYSFC
AIQDDSNISI YAIGTSSKTD SSIQAASPNE DLKSEGAQEI DSQSETVSIS SDVDYDEDRK
DLKKAKICSA YYLKTRLLLA VLSFAQNDST FSLLKLVPSL QDNTNASLVE LSRVVEAAIQ
KLSIKPLAFP NVLPQVLLLC PSISIFNLIL LHLRALIRSS PENAIKIGYS KTMHFLLTYL
FEPPTSFPLS DVSKDLLNEI TLHCATFGVS NASTAKVLRT YLKTKSEFLR TWLLKALSHL
VAPSFYFNPS TKGYSSIDFT LSSPVMPING YSVSLWLNIE SLMNDDGNYA PTTLFLISDF
LKSTLFRLLL DASKKTVVVH IGSSKDTCVV NFSTPITNFF SKIYKDNPSL NPPSWHLITL
VHRNEKSSLP NLELYIDGSA VERAACPYPF LSSTLQPLYV SLGPSIGSRN QSTPSTLAPN
VAETDALVSE NTGAASQKTS KSYKTNDSLK VPPLVPLLIG TTRFFPVPLV SSQIAIISSL
GPSYSGCFQG PINDYMTYKA STALTLEIQD SKSNTEDLLH SIQAFSRSPI AFMSCARDYV
DIMDLQLSDF CSFSVLETLK KLENQYYSHV YINRAVSSYD KAFSAEQPSF GVSSGSVTPI
IMQSISDAIY NIGGSSILLE LVGTAETEAE LNFGLQVFFS SIEDNWRFSE NVEQTHSFEI
LAQILHSKSH LLVSEETLKI IALMSGVHHT RFKHPLVMNP LLFRYLILDF DLWSKAPNSN
LFVQQLGYIV SLIENNDYAG FNVKRLMKMQ ILKKLLTAMR NCLFHKDLLP ILRLLFKVLM
TSAFVSENIR SVATYIIYAS QATGKSKPIR RSSVSIAVDR SDSNYISIKE SGYAICEEFI
DLLIKSNGEP SFLRRFSSMI TPAWLLFLLR QQDIHYFICG IRLLNQSICS LGSSFLSKFS
QKFHGFLILH DNLKDHIHLE ELWLNLLFLS LGLGIRSVQF RTDLTYKQKL DFVLKNELDN
ILPLSEVFPS LFHAIQATLE KVSNVNGKLN SENVAALRYA DDTMSFLVTL QTTYSFELTL
NYDFSELLTK VVFPFLSPVD TITAEQEMRD LLHNIRQPLP RSSSSKTFGE GIKKSVRKFS
MSGSFKRVVT PLGTQLRKDI LNDSITDMEN TSSFTASFPQ SDQALQYFDN FTVQYAEAKD
VIKGLLFSIL TCIYNRITSG QGFSYSRLLV YLPPSQIEKK STFFSGILRS TMSKLIEAVK
NDKLLLAEPS ILANISYIFT KFIRMHLLGY LKGSWLEIVD DLGSLLEEII SRPDFLAKLP
KNGRNAAMNM YSCFLDLFLL EVSDLKQTEC NAQSDKIIKS ITYWQSLLFN SKTYQKDLFS
LLWYAVYIMV ETTTGVVRLQ AVDAWRLLFL HSPGYLSDIA KTCNNDPRFA YEICKTLDND
SDKFVRWLDD NAAEVNQFML SCFFCRWEDF LKQQHKLADE EASLLQFSRL EHLRKQLAQN
TFNENILNES SASYHVWISS LFALECNRFK KMSQDQSDQE NFVAAALLSQ KNELSHENSI
LGSKTTSWEL DSTEGSERMR KRLMPCLLQS SELDSKLEAR SSGARRNRSF DTSVEAPVSL
TNEEKQAATL ILPSQEETLH DAARSDSNNS MEDEEDDVDE EDKEDKNRTV MRSIESGDSI
QDVYNVSRIF GLEATEGILL LGKQYLYLMD NFFLRSDNEI VDVNDNSIID ERDPYLQLLH
LQSLSSSGKV RRHISKENNW HWDFIDLSLV LKRFYLLRDV GLELFFKDGR SFLTILSNTK
NRDSLYQKLV ARAPGADVLS TSHFATSMSR DLGKANGKSN FLSSKLANAL SFSTTHPATK
RWERREISNF NYLQIVNTLA GRTYNDLTQY PVFPWVIADY TSKELDLNNP KTYRNFCKPM
GAQHPERESQ FNERYDLLLG LNDSQQQPFH YGTHYSSAMI VCSYLIRLRP FVDSYLALQG
GQFDHADRLF YSIEQAWRSS SKENMADVRE LIPEFFYLSE MFINGNGFDF GSRQKESTPI
NDVILPPWAK GDPAIFVQKN REALESKYVS AHLHEWIDLV FGCKQRGDEA VAATNVFHHL
SYQGAIDLEN IENEFELAAA VGIIHNFGQT PKQVFKKPHP QRGPDFTDTP LGPYLFGRFE
DSIHLLFQSC SPIIRICKKV AHIQYDPSKD EVGAFAADYT PLGPNTFLAW GRVDNTVQLI
SDQLDKQPVM FEELHSEKIT HVVACDERTF LTASLDLTLR LWTLSTNKPI KASLKRVLYG
HRYRITCVTV CKAFSIIVSG DAGGNLIIWD LNRAEFVSSL SVYKLPIQTI AVNARNAEIA
FSTGFYCCVV NVNGKILVKD KLSRIYNENS DENILCSCFY TGANSEWLHK NLFITGHPDG
IIRIWEKRLQ SNAKLEAEKN NADRPKWRFH LLRQLQHTKG LGRNRVATRQ NIITITPNGQ
ARGIFAGDDK GQVFSWMLPD TTSNVHLEKD NTSELCSLCD SRFSLMEWRS QCRACGNSNV
CSDCVSMLKD TNIKTCYECY RQMPLCYKN
