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T2FA_DICDI
ID   T2FA_DICDI              Reviewed;         556 AA.
AC   Q54WV4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=General transcription factor IIF subunit 1;
DE   AltName: Full=Transcription initiation factor IIF subunit alpha;
DE            Short=TFIIF-alpha;
GN   Name=gtf2f1; ORFNames=DDB_G0279377;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: TFIIF is a general transcription initiation factor that binds
CC       to RNA polymerase II and helps to recruit it to the initiation complex
CC       in collaboration with TFIIB. It promotes transcription elongation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFIIF alpha subunit family. {ECO:0000305}.
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DR   EMBL; AAFI02000030; EAL67837.1; -; Genomic_DNA.
DR   RefSeq; XP_641828.1; XM_636736.1.
DR   AlphaFoldDB; Q54WV4; -.
DR   STRING; 44689.DDB0302526; -.
DR   PaxDb; Q54WV4; -.
DR   PRIDE; Q54WV4; -.
DR   EnsemblProtists; EAL67837; EAL67837; DDB_G0279377.
DR   GeneID; 8622019; -.
DR   KEGG; ddi:DDB_G0279377; -.
DR   dictyBase; DDB_G0279377; gtf2f1.
DR   eggNOG; KOG2393; Eukaryota.
DR   HOGENOM; CLU_490421_0_0_1; -.
DR   InParanoid; Q54WV4; -.
DR   OMA; DGRFNAY; -.
DR   Reactome; R-DDI-113418; Formation of the Early Elongation Complex.
DR   Reactome; R-DDI-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-DDI-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR   Reactome; R-DDI-6803529; FGFR2 alternative splicing.
DR   Reactome; R-DDI-6807505; RNA polymerase II transcribes snRNA genes.
DR   Reactome; R-DDI-72086; mRNA Capping.
DR   Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR   Reactome; R-DDI-72165; mRNA Splicing - Minor Pathway.
DR   Reactome; R-DDI-73776; RNA Polymerase II Promoter Escape.
DR   Reactome; R-DDI-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR   Reactome; R-DDI-75953; RNA Polymerase II Transcription Initiation.
DR   Reactome; R-DDI-75955; RNA Polymerase II Transcription Elongation.
DR   Reactome; R-DDI-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR   Reactome; R-DDI-77075; RNA Pol II CTD phosphorylation and interaction with CE.
DR   Reactome; R-DDI-9018519; Estrogen-dependent gene expression.
DR   PRO; PR:Q54WV4; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005674; C:transcription factor TFIIF complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0001096; F:TFIIF-class transcription factor complex binding; IBA:GO_Central.
DR   GO; GO:0032091; P:negative regulation of protein binding; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:InterPro.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IBA:GO_Central.
DR   InterPro; IPR008851; TFIIF-alpha.
DR   InterPro; IPR011039; TFIIF_interaction.
DR   PANTHER; PTHR13011; PTHR13011; 1.
DR   Pfam; PF05793; TFIIF_alpha; 1.
DR   SUPFAM; SSF50916; SSF50916; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..556
FT                   /note="General transcription factor IIF subunit 1"
FT                   /id="PRO_0000330919"
FT   REGION          82..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          226..499
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..120
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..246
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        247..292
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..339
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..358
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        377..393
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        413..467
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        468..494
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   556 AA;  62219 MW;  A9364B2C418BE6D6 CRC64;
     MSESTNNPNE KTYKINLVKG TKKWNIAKFS NKIDLSSFSK PVRMYKFNPI ANMINNESNN
     FGQPTTSTYT NNHYSYKNIQ PTMTSAPNGT NSTGTTPNTT TTTTTTTTTT TTTTTAAGTP
     GAPNPAAATQ PFVRKKRYEA KPVNPKTIPW KLEDSEGNNT YQGNVEGNQA SSNYFLFMFQ
     SDGSIKAVPC NDWYNFRPKK EFQSLTTEEA EDFMKKKNQE WDVFTSRLQK KTDPSGSGSG
     GSESSGKKSI EELEEAEHRN RNEDPNRYKT TNEEKKKKKA PARRREREDE GNGEDGDAPD
     FESKFDDDDD DTYMDGDGLT GEDENQIEED EEEEDVDLTE GGLEMKKMIK KQQQQNDSED
     DLADDDDKKD NNGGTGGGDD EDDDEDDEDP DQDDLSNLPK VFGKSNADGT TNSSVKKEDD
     GGKDSKSSKK SKKKDKDSSP KSKEKKSKKN KSDSSVDNRE SKKIKKEPSS PQAVQPNSPS
     QQQQQQQQNI DPNDPPFTEE YIKIVLQKSK KVKSLDLINI FKGPLKNPDN KPIFLAMVHN
     VARVVEENGV KYLIPK
 
 
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