ID   T2FB_DICDI              Reviewed;         241 AA.
AC   Q54KT7;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=General transcription factor IIF subunit 2;
DE   AltName: Full=Transcription initiation factor IIF subunit beta;
DE            Short=TFIIF-beta;
GN   Name=gtf2f2; Synonyms=tfiif2; ORFNames=DDB_G0287131;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: TFIIF is a general transcription initiation factor that binds
CC       to RNA polymerase II and helps to recruit it to the initiation complex
CC       in collaboration with TFIIB. {ECO:0000250|UniProtKB:P13984}.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFIIF beta subunit family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL63840.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AAFI02000098; EAL63840.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_637343.1; XM_632251.1.
DR   AlphaFoldDB; Q54KT7; -.
DR   SMR; Q54KT7; -.
DR   STRING; 44689.DDB0231010; -.
DR   PaxDb; Q54KT7; -.
DR   EnsemblProtists; EAL63840; EAL63840; DDB_G0287131.
DR   GeneID; 8625965; -.
DR   KEGG; ddi:DDB_G0287131; -.
DR   dictyBase; DDB_G0287131; gtf2f2.
DR   eggNOG; KOG2905; Eukaryota.
DR   InParanoid; Q54KT7; -.
DR   Reactome; R-DDI-113418; Formation of the Early Elongation Complex.
DR   Reactome; R-DDI-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-DDI-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR   Reactome; R-DDI-6803529; FGFR2 alternative splicing.
DR   Reactome; R-DDI-6807505; RNA polymerase II transcribes snRNA genes.
DR   Reactome; R-DDI-72086; mRNA Capping.
DR   Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR   Reactome; R-DDI-72165; mRNA Splicing - Minor Pathway.
DR   Reactome; R-DDI-73776; RNA Polymerase II Promoter Escape.
DR   Reactome; R-DDI-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR   Reactome; R-DDI-75953; RNA Polymerase II Transcription Initiation.
DR   Reactome; R-DDI-75955; RNA Polymerase II Transcription Elongation.
DR   Reactome; R-DDI-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR   Reactome; R-DDI-77075; RNA Pol II CTD phosphorylation and interaction with CE.
DR   Reactome; R-DDI-9018519; Estrogen-dependent gene expression.
DR   PRO; PR:Q54KT7; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005674; C:transcription factor TFIIF complex; ISS:dictyBase.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISS:dictyBase.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR003196; TFIIF_beta.
DR   InterPro; IPR040450; TFIIF_beta_HTH.
DR   InterPro; IPR040504; TFIIF_beta_N.
DR   InterPro; IPR011039; TFIIF_interaction.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10445; PTHR10445; 1.
DR   Pfam; PF02270; TFIIF_beta; 1.
DR   Pfam; PF17683; TFIIF_beta_N; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF50916; SSF50916; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..241
FT                   /note="General transcription factor IIF subunit 2"
FT                   /id="PRO_0000330920"
SQ   SEQUENCE   241 AA;  27535 MW;  344833F7B827E081 CRC64;
     MSEEKNDALV GEVNTDNADN QVWLIKVPKF LSESWQKIGQ GEIGQIHIKG GDNISLSYGP
     DVGQEFQLIT TANTLDNQPL KIFSEDKDGA LALEGNIGLR CDIKIDVESP QYRDLMKSRH
     TKYNTKTRMT QVIDESELFT PTLFDANKVK VSTVGITQKK KSTDKKEKLP EDEVLDLIFS
     AFRAEKHLDL KTLESFTEQP KNHLKTILEK VCILNKRGPY HHLYELKPEF RDKDNSKDEK
     K