ID   T2FB_XENLA              Reviewed;         264 AA.
AC   Q03123; Q6GN43;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=General transcription factor IIF subunit 2;
DE   AltName: Full=Transcription initiation factor IIF subunit beta;
DE            Short=TFIIF-beta;
DE   AltName: Full=Transcription initiation factor RAP30;
GN   Name=gtf2f2; Synonyms=rap30;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Oocyte;
RX   PubMed=1475205; DOI=10.1093/nar/20.23.6414;
RA   Gong D.-W., Hashimoto S., Wada K., Roeder R.G., Nakatani Y., Horikoshi M.;
RT   "Imperfect conservation of a sigma factor-like subregion in Xenopus general
RT   transcription factor RAP30.";
RL   Nucleic Acids Res. 20:6414-6414(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: TFIIF is a general transcription initiation factor that binds
CC       to RNA polymerase II and helps to recruit it to the initiation complex
CC       in collaboration with TFIIB. {ECO:0000250|UniProtKB:P13984}.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the TFIIF beta subunit family. {ECO:0000305}.
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DR   EMBL; Z15132; CAA78835.1; -; mRNA.
DR   EMBL; BC073677; AAH73677.1; -; mRNA.
DR   PIR; S30220; S30220.
DR   RefSeq; NP_001082266.1; NM_001088797.1.
DR   AlphaFoldDB; Q03123; -.
DR   SMR; Q03123; -.
DR   MaxQB; Q03123; -.
DR   DNASU; 398333; -.
DR   GeneID; 398333; -.
DR   KEGG; xla:398333; -.
DR   CTD; 398333; -.
DR   Xenbase; XB-GENE-866607; gtf2f2.S.
DR   OMA; KYIANKW; -.
DR   OrthoDB; 1496393at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 398333; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0005674; C:transcription factor TFIIF complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR003196; TFIIF_beta.
DR   InterPro; IPR040450; TFIIF_beta_HTH.
DR   InterPro; IPR040504; TFIIF_beta_N.
DR   InterPro; IPR011039; TFIIF_interaction.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10445; PTHR10445; 1.
DR   Pfam; PF02270; TFIIF_beta; 1.
DR   Pfam; PF17683; TFIIF_beta_N; 1.
DR   PIRSF; PIRSF015849; TFIIF-beta; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF50916; SSF50916; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..264
FT                   /note="General transcription factor IIF subunit 2"
FT                   /id="PRO_0000211238"
SQ   SEQUENCE   264 AA;  30140 MW;  A26320BA82CC4DD1 CRC64;
     MSAEKGELDL NGAKQNTGMW LVKLPKYLAQ QWAKATGRGE VGKLRIVKNQ GKTEVSFTLN
     EELASIQDIG GKPASSLVST PREHPFLLQS VGGQTLTVLT ESLSGQSEDK SENRVIDKLA
     LEGIVVHRAE CRPAASDNYM QMKRKQIEES SKPKRQSQQL EKAVTSNYKP VSNHQYNIEY
     EKKKKDDGKR ARVDKHQVLD MLFSAFEKHQ YYNIKDLVDI TKQPVTYLKE ILRDIGIYNM
     KGTHKNTWEL KPEYRHYQGE DKSD