ID   T2M7_METJA              Reviewed;         146 AA.
AC   Q58599;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Putative type II restriction enzyme MjaORF1200P {ECO:0000303|PubMed:12654995};
DE            Short=R.MjaORF1200P {ECO:0000303|PubMed:12654995};
DE            EC=3.1.21.4;
GN   OrderedLocusNames=MJ1199;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=12654995; DOI=10.1093/nar/gkg274;
RA   Roberts R.J., Belfort M., Bestor T., Bhagwat A.S., Bickle T.A.,
RA   Bitinaite J., Blumenthal R.M., Degtyarev S.K., Dryden D.T., Dybvig K.,
RA   Firman K., Gromova E.S., Gumport R.I., Halford S.E., Hattman S.,
RA   Heitman J., Hornby D.P., Janulaitis A., Jeltsch A., Josephsen J., Kiss A.,
RA   Klaenhammer T.R., Kobayashi I., Kong H., Krueger D.H., Lacks S.,
RA   Marinus M.G., Miyahara M., Morgan R.D., Murray N.E., Nagaraja V.,
RA   Piekarowicz A., Pingoud A., Raleigh E., Rao D.N., Reich N., Repin V.E.,
RA   Selker E.U., Shaw P.C., Stein D.C., Stoddard B.L., Szybalski W.,
RA   Trautner T.A., Van Etten J.L., Vitor J.M., Wilson G.G., Xu S.Y.;
RT   "A nomenclature for restriction enzymes, DNA methyltransferases, homing
RT   endonucleases and their genes.";
RL   Nucleic Acids Res. 31:1805-1812(2003).
CC   -!- FUNCTION: A putative type II restriction enzyme, its methylase would be
CC       M.MjaORF1200P (AC Q58600). {ECO:0000303|PubMed:12654995}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of DNA to give specific double-
CC         stranded fragments with terminal 5'-phosphates.; EC=3.1.21.4;
CC         Evidence={ECO:0000303|PubMed:12654995};
CC   -!- SIMILARITY: To A.pernix APE2001. {ECO:0000305}.
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DR   EMBL; L77117; AAB99204.1; -; Genomic_DNA.
DR   PIR; F64449; F64449.
DR   AlphaFoldDB; Q58599; -.
DR   SMR; Q58599; -.
DR   STRING; 243232.MJ_1199; -.
DR   REBASE; 4871; MjaORF1200P.
DR   EnsemblBacteria; AAB99204; AAB99204; MJ_1199.
DR   KEGG; mja:MJ_1199; -.
DR   eggNOG; arCOG01019; Archaea.
DR   HOGENOM; CLU_140136_0_0_2; -.
DR   InParanoid; Q58599; -.
DR   OMA; LFKLAFK; -.
DR   PhylomeDB; Q58599; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   InterPro; IPR018665; DUF2122_RecB-nuclease-rel.
DR   Pfam; PF09895; DUF2122; 1.
PE   4: Predicted;
KW   DNA-binding; Endonuclease; Hydrolase; Nuclease; Reference proteome;
KW   Restriction system.
FT   CHAIN           1..146
FT                   /note="Putative type II restriction enzyme MjaORF1200P"
FT                   /id="PRO_0000107212"
SQ   SEQUENCE   146 AA;  16296 MW;  9934CB449198D85C CRC64;
     MRKMFICLHN TYSAKQVEEF GRIAYGFDIN TIVVTKATAS AAQSGIPTLH KMAYKLGKNV
     LFFEELDDAI EVLRPEKVFL IGNKSICDEK VDFNEVGEND LVVFCGASTG FTKLELEKGL
     GRYIVENEIG ALGNLAIFLY EMSKKI