T2R10_PANPA
ID T2R10_PANPA Reviewed; 307 AA.
AC Q646D7;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Taste receptor type 2 member 10;
DE Short=T2R10;
GN Name=TAS2R10;
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15496549; DOI=10.1093/molbev/msi027;
RA Fischer A., Gilad Y., Man O., Paeaebo S.;
RT "Evolution of bitter taste receptors in humans and apes.";
RL Mol. Biol. Evol. 22:432-436(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15466715; DOI=10.1073/pnas.0404894101;
RA Parry C.M., Erkner A., le Coutre J.;
RT "Divergence of T2R chemosensory receptor families in humans, bonobos, and
RT chimpanzees.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14830-14834(2004).
CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC and is gustducin-linked. May play a role in sensing the chemical
CC composition of the gastrointestinal content. The activity of this
CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC bitter compounds; individual taste cells can discriminate among bitter
CC stimuli.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AY724852; AAU21082.1; -; Genomic_DNA.
DR EMBL; AY677139; AAV28567.1; -; Genomic_DNA.
DR RefSeq; XP_003829653.1; XM_003829605.2.
DR AlphaFoldDB; Q646D7; -.
DR SMR; Q646D7; -.
DR STRING; 9597.XP_003829653.1; -.
DR Ensembl; ENSPPAT00000021749; ENSPPAP00000004754; ENSPPAG00000019846.
DR GeneID; 100983738; -.
DR KEGG; pps:100983738; -.
DR CTD; 50839; -.
DR eggNOG; ENOG502T3AX; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR OMA; WLFTFPQ; -.
DR OrthoDB; 1010573at2759; -.
DR Proteomes; UP000240080; Chromosome 12.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0033038; F:bitter taste receptor activity; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..307
FT /note="Taste receptor type 2 member 10"
FT /id="PRO_0000082239"
FT TOPO_DOM 1..6
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..27
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..42
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..179
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..257
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..307
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 307 AA; 35451 MW; 76F01A02363A3C95 CRC64;
MLRVVEGIFI FVVISESVFG VLGNGFIGLV NCIDCAKNKL STIGFILTGL AISRIFLIWI
IITDGFIQIF SPNIYASSNL IEYISYFWVI GNQSSMWFAT SLSIFYFLKI ANFSNYIFLW
LKSRTNMVLP FMIVFLLISS LLNFAYIAKI LNDYKMKNDT VWDLNMYKSE YFIKQILLNL
GVIFFFTLSL ITCVLLIISL WRHNRQMQSN VTGLRDSNTE AHVKAMKVLI SFIILFILYF
IGMAIEISYF TVRENKLLLM FGMTTTAIYP WGHSFILILG NSKLKQASLR VLQQLKCCEK
RKNLRVT
