ID   T2R10_PANTR             Reviewed;         307 AA.
AC   Q646B5;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Taste receptor type 2 member 10;
DE            Short=T2R10;
GN   Name=TAS2R10;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15496549; DOI=10.1093/molbev/msi027;
RA   Fischer A., Gilad Y., Man O., Paeaebo S.;
RT   "Evolution of bitter taste receptors in humans and apes.";
RL   Mol. Biol. Evol. 22:432-436(2005).
CC   -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC       and is gustducin-linked. May play a role in sensing the chemical
CC       composition of the gastrointestinal content. The activity of this
CC       receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC       and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC       bitter compounds; individual taste cells can discriminate among bitter
CC       stimuli.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000305}.
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DR   EMBL; AY724882; AAU21104.1; -; Genomic_DNA.
DR   RefSeq; NP_001009142.1; NM_001009142.1.
DR   AlphaFoldDB; Q646B5; -.
DR   SMR; Q646B5; -.
DR   STRING; 9598.ENSPTRP00000054731; -.
DR   PaxDb; Q646B5; -.
DR   Ensembl; ENSPTRT00000008672; ENSPTRP00000054731; ENSPTRG00000004685.
DR   GeneID; 493892; -.
DR   KEGG; ptr:493892; -.
DR   CTD; 50839; -.
DR   VGNC; VGNC:13476; TAS2R10.
DR   eggNOG; ENOG502T3AX; Eukaryota.
DR   GeneTree; ENSGT00960000186648; -.
DR   InParanoid; Q646B5; -.
DR   OMA; WLFTFPQ; -.
DR   OrthoDB; 1010573at2759; -.
DR   Proteomes; UP000002277; Chromosome 12.
DR   Bgee; ENSPTRG00000004685; Expressed in colon and 9 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0033038; F:bitter taste receptor activity; IEA:Ensembl.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..307
FT                   /note="Taste receptor type 2 member 10"
FT                   /id="PRO_0000082240"
FT   TOPO_DOM        1..6
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..27
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..42
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        64..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        122..126
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        148..179
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        201..227
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        249..257
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        279..307
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        158
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   307 AA;  35451 MW;  76F01A02363A3C95 CRC64;
     MLRVVEGIFI FVVISESVFG VLGNGFIGLV NCIDCAKNKL STIGFILTGL AISRIFLIWI
     IITDGFIQIF SPNIYASSNL IEYISYFWVI GNQSSMWFAT SLSIFYFLKI ANFSNYIFLW
     LKSRTNMVLP FMIVFLLISS LLNFAYIAKI LNDYKMKNDT VWDLNMYKSE YFIKQILLNL
     GVIFFFTLSL ITCVLLIISL WRHNRQMQSN VTGLRDSNTE AHVKAMKVLI SFIILFILYF
     IGMAIEISYF TVRENKLLLM FGMTTTAIYP WGHSFILILG NSKLKQASLR VLQQLKCCEK
     RKNLRVT