T2R13_HUMAN
ID T2R13_HUMAN Reviewed; 303 AA.
AC Q9NYV9; Q4G0I5; Q502V8; Q645X2;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Taste receptor type 2 member 13;
DE Short=T2R13;
DE AltName: Full=Taste receptor family B member 3;
DE Short=TRB3;
GN Name=TAS2R13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TOPOLOGY.
RX PubMed=10761934; DOI=10.1016/s0092-8674(00)80705-9;
RA Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
RA Zuker C.S.;
RT "A novel family of mammalian taste receptors.";
RL Cell 100:693-702(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15496549; DOI=10.1093/molbev/msi027;
RA Fischer A., Gilad Y., Man O., Paeaebo S.;
RT "Evolution of bitter taste receptors in humans and apes.";
RL Mol. Biol. Evol. 22:432-436(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-259.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP CHARACTERIZATION.
RX PubMed=10761935; DOI=10.1016/s0092-8674(00)80706-0;
RA Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W.,
RA Zuker C.S., Ryba N.J.P.;
RT "T2Rs function as bitter taste receptors.";
RL Cell 100:703-711(2000).
RN [5]
RP REVIEW.
RX PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA Montmayeur J.-P., Matsunami H.;
RT "Receptors for bitter and sweet taste.";
RL Curr. Opin. Neurobiol. 12:366-371(2002).
RN [6]
RP REVIEW.
RX PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA Margolskee R.F.;
RT "Molecular mechanisms of bitter and sweet taste transduction.";
RL J. Biol. Chem. 277:1-4(2002).
RN [7]
RP REVIEW.
RX PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA Zuker C.S., Ryba N.J.;
RT "Coding of sweet, bitter, and umami tastes: different receptor cells
RT sharing similar signaling pathways.";
RL Cell 112:293-301(2003).
RN [8]
RP VARIANT [LARGE SCALE ANALYSIS] SER-149.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC and is gustducin-linked. May play a role in sensing the chemical
CC composition of the gastrointestinal content. The activity of this
CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC and lead to the gating of TRPM5.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC tongue and palate epithelium and exclusively in gustducin-positive
CC cells.
CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC bitter compounds; individual taste cells can discriminate among bitter
CC stimuli.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AF227137; AAF43910.1; -; Genomic_DNA.
DR EMBL; AY724945; AAU21147.1; -; Genomic_DNA.
DR EMBL; BC069376; AAH69376.1; -; mRNA.
DR EMBL; BC095518; AAH95518.1; -; mRNA.
DR CCDS; CCDS8635.1; -.
DR RefSeq; NP_076409.1; NM_023920.2.
DR AlphaFoldDB; Q9NYV9; -.
DR SMR; Q9NYV9; -.
DR BioGRID; 119148; 2.
DR STRING; 9606.ENSP00000375095; -.
DR ChEMBL; CHEMBL4523471; -.
DR GlyGen; Q9NYV9; 2 sites.
DR iPTMnet; Q9NYV9; -.
DR PhosphoSitePlus; Q9NYV9; -.
DR BioMuta; TAS2R13; -.
DR DMDM; 29839659; -.
DR PaxDb; Q9NYV9; -.
DR PRIDE; Q9NYV9; -.
DR Antibodypedia; 23407; 139 antibodies from 21 providers.
DR DNASU; 50838; -.
DR Ensembl; ENST00000390677.2; ENSP00000375095.2; ENSG00000212128.2.
DR Ensembl; ENST00000574870.1; ENSP00000461365.1; ENSG00000273457.1.
DR Ensembl; ENST00000613662.1; ENSP00000478277.1; ENSG00000277254.1.
DR GeneID; 50838; -.
DR KEGG; hsa:50838; -.
DR MANE-Select; ENST00000390677.2; ENSP00000375095.2; NM_023920.2; NP_076409.1.
DR UCSC; uc001qzg.1; human.
DR CTD; 50838; -.
DR DisGeNET; 50838; -.
DR GeneCards; TAS2R13; -.
DR HGNC; HGNC:14919; TAS2R13.
DR HPA; ENSG00000212128; Not detected.
DR MIM; 604792; gene.
DR neXtProt; NX_Q9NYV9; -.
DR OpenTargets; ENSG00000212128; -.
DR PharmGKB; PA37929; -.
DR VEuPathDB; HostDB:ENSG00000212128; -.
DR eggNOG; ENOG502TE6X; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_2_0_1; -.
DR InParanoid; Q9NYV9; -.
DR OMA; GLRIMIF; -.
DR OrthoDB; 1061430at2759; -.
DR PhylomeDB; Q9NYV9; -.
DR TreeFam; TF335891; -.
DR PathwayCommons; Q9NYV9; -.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-HSA-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 50838; 14 hits in 1061 CRISPR screens.
DR GeneWiki; TAS2R13; -.
DR GenomeRNAi; 50838; -.
DR Pharos; Q9NYV9; Tchem.
DR PRO; PR:Q9NYV9; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9NYV9; protein.
DR Bgee; ENSG00000212128; Expressed in corpus callosum and 24 other tissues.
DR Genevisible; Q9NYV9; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0033038; F:bitter taste receptor activity; IDA:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:UniProtKB.
DR GO; GO:0032467; P:positive regulation of cytokinesis; IMP:UniProtKB.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 1: Evidence at protein level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..303
FT /note="Taste receptor type 2 member 13"
FT /id="PRO_0000082247"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..85
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..184
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..261
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 166
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 149
FT /note="N -> S (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036432"
FT VARIANT 259
FT /note="N -> S (in dbSNP:rs1015443)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_021853"
SQ SEQUENCE 303 AA; 35118 MW; 756BF5382E36BFB5 CRC64;
MESALPSIFT LVIIAEFIIG NLSNGFIVLI NCIDWVSKRE LSSVDKLLII LAISRIGLIW
EILVSWFLAL HYLAIFVSGT GLRIMIFSWI VSNHFNLWLA TIFSIFYLLK IASFSSPAFL
YLKWRVNKVI LMILLGTLVF LFLNLIQINM HIKDWLDRYE RNTTWNFSMS DFETFSVSVK
FTMTMFSLTP FTVAFISFLL LIFSLQKHLQ KMQLNYKGHR DPRTKVHTNA LKIVISFLLF
YASFFLCVLI SWISELYQNT VIYMLCETIG VFSPSSHSFL LILGNAKLRQ AFLLVAAKVW
AKR
