T2R13_MOUSE
ID T2R13_MOUSE Reviewed; 305 AA.
AC Q7M720;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Taste receptor type 2 member 13;
DE Short=T2R13;
DE AltName: Full=Taste receptor type 2 member 121;
DE Short=T2R121;
DE Short=mT2R48;
GN Name=Tas2r13 {ECO:0000250|UniProtKB:Q9NYV9};
GN Synonyms=Tas2r121 {ECO:0000312|MGI:MGI:2681259};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000312|EMBL:AAI04411.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000305, ECO:0000312|EMBL:DAA01216.1}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC and is gustducin-linked. May play a role in sensing the chemical
CC composition of the gastrointestinal content. The activity of this
CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC and lead to the gating of TRPM5 (By similarity).
CC {ECO:0000250|UniProtKB:Q9NYV9}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC bitter compounds; individual taste cells can discriminate among bitter
CC stimuli. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
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DR EMBL; AC124523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC104410; AAI04411.1; -; mRNA.
DR EMBL; BC104411; AAI04412.1; -; mRNA.
DR EMBL; BK001077; DAA01216.1; -; Genomic_DNA.
DR CCDS; CCDS20618.1; -.
DR RefSeq; NP_996907.1; NM_207024.1.
DR AlphaFoldDB; Q7M720; -.
DR SMR; Q7M720; -.
DR STRING; 10090.ENSMUSP00000093044; -.
DR GlyGen; Q7M720; 1 site.
DR PhosphoSitePlus; Q7M720; -.
DR PaxDb; Q7M720; -.
DR PRIDE; Q7M720; -.
DR DNASU; 387349; -.
DR Ensembl; ENSMUST00000095395; ENSMUSP00000093044; ENSMUSG00000071150.
DR GeneID; 387349; -.
DR KEGG; mmu:387349; -.
DR UCSC; uc009ejj.1; mouse.
DR CTD; 387349; -.
DR MGI; MGI:2681259; Tas2r121.
DR VEuPathDB; HostDB:ENSMUSG00000071150; -.
DR eggNOG; ENOG502TE6X; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_2_0_1; -.
DR InParanoid; Q7M720; -.
DR OMA; GLRIMIF; -.
DR OrthoDB; 1061430at2759; -.
DR PhylomeDB; Q7M720; -.
DR TreeFam; TF335891; -.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-MMU-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 387349; 1 hit in 74 CRISPR screens.
DR PRO; PR:Q7M720; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7M720; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR GO; GO:0032467; P:positive regulation of cytokinesis; ISO:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Sensory transduction; Taste; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..305
FT /note="Taste receptor type 2 member 13"
FT /id="PRO_0000082252"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..88
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..182
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..262
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 305 AA; 35521 MW; B97DB33A6DD6FAA7 CRC64;
MGSNVYGILT MVMIAEFVFG NMSNGFIVLI NCIDWVRKGT LSSIGWILLF LAISRMVLIW
EMLITWIKYM KYSFSFVTGT ELRGIMFTWV ISNHFSLWLA TILSIFYLLK IASFSKPVFL
YLKWREKKVL LIVLLGNLIF LMLNILQINK HIEHWMYQYE RNITWSSRVS DFAGFSNLVL
LEMIVFSVTP FTVALVSFIL LIFSLWKHLQ KMHLNSRGER DPSTKAHVNA LRIMVSFLLL
YATYFISFFL SLIPMAHKTR LGLMFSITVG LFYPSSHSFI LILGHSNLRQ ASLWVMTYLK
CGQKH
