T2R33_HUMAN
ID T2R33_HUMAN Reviewed; 309 AA.
AC P0DSN6;
DT 12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT 12-AUG-2020, sequence version 1.
DT 03-AUG-2022, entry version 8.
DE RecName: Full=Putative taste receptor type 2 member 33 {ECO:0000305};
DE Short=T2R33 {ECO:0000303|Ref.1};
DE Short=hGR33 {ECO:0000303|Ref.1};
GN Name=TAS2R33 {ECO:0000312|HGNC:HGNC:19114};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Zuker C.S., Adler J.E., Ryba N., Mueller K., Hoon M.;
RT "T2r taste receptor family.";
RL Patent number WO0118050, 15-MAR-2001.
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
CC -!- CAUTION: Product of a dubious gene prediction. Zuker et al. identified
CC this gene on chromosome 12. However, it is not currently present on the
CC reference genome assembly (GRCh38/hg38). {ECO:0000305}.
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DR EMBL; AX097751; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR AlphaFoldDB; P0DSN6; -.
DR SMR; P0DSN6; -.
DR GlyGen; P0DSN6; 2 sites.
DR GeneCards; TAS2R33; -.
DR HGNC; HGNC:19114; TAS2R33.
DR neXtProt; NX_P0DSN6; -.
DR Proteomes; UP000005640; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 5: Uncertain;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..309
FT /note="Putative taste receptor type 2 member 33"
FT /id="PRO_0000450481"
FT TOPO_DOM 1
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 23..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..86
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..181
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..259
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 86
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 309 AA; 35400 MW; 28157A230BBAF343 CRC64;
MVYFLPIIFS ILVVFAFVLG NFSNGFIALV NVIDWVKRQK ISSADQILTA LVVSRVGLLW
VILLHWYANV FNSALYSLEV RIVASNISAV INHFSIWLAA SLSIFYLLKI ANFSNLIFLH
LKKRIKSVVL VILLGPLVFL ICNLAVITMD ERVWTKEYEG NVTWKIKLRN AIHLSSLTVT
TLANLIPFTL SLICFLLLIC SLCKHLKKMQ LHSKGSQDPS TKVHIKALQT VISFLMLCAI
YFLSIMISVW NLRSLENKPV FMFCKAIRFS YPSIHPFILI WGNKKLKQTF LSVFWQVRYW
VKGEKPSSP
