ID   T2R38_HYLKL             Reviewed;         333 AA.
AC   Q697L2;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Taste receptor type 2 member 38;
DE            Short=T2R38;
GN   Name=TAS2R38;
OS   Hylobates klossii (Kloss's gibbon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Hylobates.
OX   NCBI_TaxID=9587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Davidson A.C., Pakstis A.J., Speed W.C., Odunsi A., Okonafua F.,
RA   Kajuna S.L.J., Kungulilo S.V., Friedlaender J., Lu R.-B., Grigorenko E.L.,
RA   Zhukova O.V., Schultz L.O., Bonne-Tamir B., Duffy V., Bartoshuk L.,
RA   Kidd K.K., Kidd J.R.;
RT   "A global survey of haplotype frequencies for the TAS2R38 (PTC) gene.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC       and is gustducin-linked. May play a role in sensing the chemical
CC       composition of the gastrointestinal content. The activity of this
CC       receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC       and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC       bitter compounds; individual taste cells can discriminate among bitter
CC       stimuli.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY566405; AAS67625.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q697L2; -.
DR   SMR; Q697L2; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0033038; F:bitter taste receptor activity; IEA:InterPro.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR007960; TAS2R.
DR   InterPro; IPR030050; TAS2R38.
DR   PANTHER; PTHR11394:SF52; PTHR11394:SF52; 1.
DR   Pfam; PF05296; TAS2R; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..333
FT                   /note="Taste receptor type 2 member 38"
FT                   /id="PRO_0000082274"
FT   TOPO_DOM        1..17
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        18..38
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..94
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        116..142
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        164..190
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        212..251
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        273..276
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..333
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        178
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   333 AA;  37891 MW;  883417F66C5AC7E2 CRC64;
     MLTLTRICTV SYEVRSTFLF ISVLEFAVGF LTNAFIFLVN FWDVVKRQPL SNSDCVLLCL
     SISRLFLHGL LFLSAIQLTH FQKLSEPLNH SYHAIIMLWM IANQANLWLA TCLSLLYCSK
     LIRSSHTFLI CLASWVSRKI CQMLLGIILC SCICTVLCVW CYFSRPHFTV TTVLFTNNNT
     RLNWQIKDLN LFYSFLFCYL WSVPPFLLFL VSSGMLTVSL GRHMRTMKVY TRDFRDPSLE
     AHIKALKSLV SFFCFFVISS CAAFISVPLL ILWRDKIGVM VCVGIMAACP SGHAAILISG
     NAKLRRAVTT ILLWAQSSLK VRADHKADSR TLC