T2R38_MOUSE
ID T2R38_MOUSE Reviewed; 331 AA.
AC Q7TQA6; A0PK79; Q4VHF0;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Taste receptor type 2 member 38;
DE Short=T2R38;
DE AltName: Full=T2R138;
DE AltName: Full=mT2R31;
GN Name=Tas2r38; Synonyms=T2r31, Tas2r138;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:AAP40339.1};
RN [1] {ECO:0000312|EMBL:AAP40339.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAP40339.1};
RX PubMed=12734386; DOI=10.1152/physiolgenomics.00060.2003;
RA Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.;
RT "Evolutionary relationships of the Tas2r receptor gene families in mouse
RT and human.";
RL Physiol. Genomics 14:73-82(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=15886333; DOI=10.1152/physiolgenomics.00030.2005;
RA Wu S.V., Chen M.C., Rozengurt E.;
RT "Genomic organization, expression, and function of bitter taste receptors
RT (T2R) in mouse and rat.";
RL Physiol. Genomics 22:139-149(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000303|PubMed:12734386}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Low levels in tongue, stomach and duodenum.
CC {ECO:0000269|PubMed:15886333}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AF532789; AAP40339.1; -; Genomic_DNA.
DR EMBL; AY916509; AAX99132.1; -; mRNA.
DR EMBL; AC153378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC128016; AAI28017.1; -; mRNA.
DR EMBL; BK001093; DAA01232.1; -; Genomic_DNA.
DR CCDS; CCDS20038.1; -.
DR RefSeq; NP_001001451.1; NM_001001451.1.
DR AlphaFoldDB; Q7TQA6; -.
DR SMR; Q7TQA6; -.
DR STRING; 10090.ENSMUSP00000075876; -.
DR GlyGen; Q7TQA6; 1 site.
DR PhosphoSitePlus; Q7TQA6; -.
DR PaxDb; Q7TQA6; -.
DR PRIDE; Q7TQA6; -.
DR Antibodypedia; 50262; 149 antibodies from 21 providers.
DR Ensembl; ENSMUST00000076565; ENSMUSP00000075876; ENSMUSG00000058250.
DR GeneID; 387513; -.
DR KEGG; mmu:387513; -.
DR UCSC; uc009bne.1; mouse.
DR CTD; 387513; -.
DR MGI; MGI:2681306; Tas2r138.
DR VEuPathDB; HostDB:ENSMUSG00000058250; -.
DR eggNOG; ENOG502T15G; Eukaryota.
DR GeneTree; ENSGT00960000186638; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q7TQA6; -.
DR OMA; TIIMLWM; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; Q7TQA6; -.
DR TreeFam; TF335891; -.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-MMU-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 387513; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q7TQA6; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7TQA6; protein.
DR Bgee; ENSMUSG00000058250; Expressed in proximal tubule.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; NAS:UniProtKB.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR InterPro; IPR007960; TAS2R.
DR InterPro; IPR030050; TAS2R38.
DR PANTHER; PTHR11394:SF52; PTHR11394:SF52; 1.
DR Pfam; PF05296; TAS2R; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..331
FT /note="Taste receptor type 2 member 38"
FT /id="PRO_0000082279"
FT TOPO_DOM 1..17
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..94
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..189
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 177
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 331 AA; 36966 MW; 37A9B6D0885BF9C0 CRC64;
MLSLTPVLTV SYEAKISFLF LSAMEFAVGI LANAFIVLVN VWDVVKKQPL NNCDIALLCL
SITRLFLQGL LLLDAIQLAC FQQMKDPLSH NYQAILTLWM IANQVSLWLA ACLSLLYCSK
IVRFSHTFPL HVASWVSRRF LQMLLVVLLL SCICTALCLW DFFCRSHSTV TSLLHLNSTE
FSLQIAKLNF FYSFIFCNVG SVPPSLAFLV SSGVLVISLG SHMRTMKSQT SSSGDPSLEA
HIRAIIFLIS FFCFYVVSFC AALISIPLLM LWHNKGGVMI CIGMMAACPS GHAAILISGN
AKLRRAIETM LFWFQSRQKV RPVHKVPPRT L
