T2R38_PANPA
ID T2R38_PANPA Reviewed; 333 AA.
AC Q697L6; Q646C9;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Taste receptor type 2 member 38;
DE Short=T2R38;
GN Name=TAS2R38;
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Davidson A.C., Pakstis A.J., Speed W.C., Odunsi A., Okonafua F.,
RA Kajuna S.L.J., Kungulilo S.V., Friedlaender J., Lu R.-B., Grigorenko E.L.,
RA Zhukova O.V., Schultz L.O., Bonne-Tamir B., Duffy V., Bartoshuk L.,
RA Kidd K.K., Kidd J.R.;
RT "A global survey of haplotype frequencies for the TAS2R38 (PTC) gene.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15496549; DOI=10.1093/molbev/msi027;
RA Fischer A., Gilad Y., Man O., Paeaebo S.;
RT "Evolution of bitter taste receptors in humans and apes.";
RL Mol. Biol. Evol. 22:432-436(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15466715; DOI=10.1073/pnas.0404894101;
RA Parry C.M., Erkner A., le Coutre J.;
RT "Divergence of T2R chemosensory receptor families in humans, bonobos, and
RT chimpanzees.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14830-14834(2004).
CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC and is gustducin-linked. May play a role in sensing the chemical
CC composition of the gastrointestinal content. The activity of this
CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC bitter compounds; individual taste cells can discriminate among bitter
CC stimuli.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY566401; AAS67621.1; -; Genomic_DNA.
DR EMBL; AY724867; AAU21090.1; -; Genomic_DNA.
DR EMBL; AY677143; AAV28571.1; -; Genomic_DNA.
DR RefSeq; XP_003813418.1; XM_003813370.2.
DR AlphaFoldDB; Q697L6; -.
DR SMR; Q697L6; -.
DR STRING; 9597.XP_003813418.1; -.
DR Ensembl; ENSPPAT00000021403; ENSPPAP00000004675; ENSPPAG00000019525.
DR GeneID; 100992496; -.
DR KEGG; pps:100992496; -.
DR CTD; 5726; -.
DR eggNOG; ENOG502T15G; Eukaryota.
DR GeneTree; ENSGT00960000186638; -.
DR OMA; TIIMLWM; -.
DR OrthoDB; 1010573at2759; -.
DR Proteomes; UP000240080; Chromosome 7.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0033038; F:bitter taste receptor activity; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR007960; TAS2R.
DR InterPro; IPR030050; TAS2R38.
DR PANTHER; PTHR11394:SF52; PTHR11394:SF52; 1.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..333
FT /note="Taste receptor type 2 member 38"
FT /id="PRO_0000082275"
FT TOPO_DOM 1..17
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..94
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..190
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 333 AA; 37857 MW; EDFE2C50CDFE1D6D CRC64;
MLTLTRIHTV SYEVRSTFLF ISVLEFAVGF LTNAFVFLVN FWDVVKRQPL SNSDCVLLCL
SISRLFLHGL LFLSAIQLTH FQKLSEPLNH SYQAINMLWM IANQANLWLA ACLSLLYCSK
LIRFSHTFLI CLASWVSRKI SQMLLGIILC SCICTVLCVW CFFSRPHFTV TTVLFMNNNT
RLNWQIKDLN LFYSFLFCYL WSVPPFLLFL VSSGMLTVSL GRHMRTMKVY TRDSRDPSLE
AHIKALKSLV SFFCFFVISS CAAFISVPLL ILWRDKIGVM VCVGIMAACP SGHAAVLISG
NAKLRRAVTT ILLWAQSSLK VRADHKADSR TLC
