T2R38_PONPY
ID T2R38_PONPY Reviewed; 333 AA.
AC Q697L3; Q645U3;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 2.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Taste receptor type 2 member 38;
DE Short=T2R38;
GN Name=TAS2R38;
OS Pongo pygmaeus (Bornean orangutan).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9600;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Davidson A.C., Pakstis A.J., Speed W.C., Odunsi A., Okonafua F.,
RA Kajuna S.L.J., Kungulilo S.V., Friedlaender J., Lu R.-B., Grigorenko E.L.,
RA Zhukova O.V., Schultz L.O., Bonne-Tamir B., Duffy V., Bartoshuk L.,
RA Kidd K.K., Kidd J.R.;
RT "A global survey of haplotype frequencies for the TAS2R38 (PTC) gene.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15496549; DOI=10.1093/molbev/msi027;
RA Fischer A., Gilad Y., Man O., Paeaebo S.;
RT "Evolution of bitter taste receptors in humans and apes.";
RL Mol. Biol. Evol. 22:432-436(2005).
CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC and is gustducin-linked. May play a role in sensing the chemical
CC composition of the gastrointestinal content. The activity of this
CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC bitter compounds; individual taste cells can discriminate among bitter
CC stimuli.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AY566404; AAS67624.1; -; Genomic_DNA.
DR EMBL; AY724991; AAU21176.1; -; Genomic_DNA.
DR AlphaFoldDB; Q697L3; -.
DR SMR; Q697L3; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0033038; F:bitter taste receptor activity; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR007960; TAS2R.
DR InterPro; IPR030050; TAS2R38.
DR PANTHER; PTHR11394:SF52; PTHR11394:SF52; 1.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..333
FT /note="Taste receptor type 2 member 38"
FT /id="PRO_0000082278"
FT TOPO_DOM 1..17
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..94
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..190
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 6
FT /note="R -> H (in Ref. 2; AAU21176)"
FT /evidence="ECO:0000305"
FT CONFLICT 295
FT /note="A -> G (in Ref. 2; AAU21176)"
FT /evidence="ECO:0000305"
FT CONFLICT 322
FT /note="R -> K (in Ref. 2; AAU21176)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 333 AA; 37826 MW; DE274AD79B8187D0 CRC64;
MLTLTRICAV SYEVRSTFLF ISVLEFAVGF LTNAFIFLVN FWDVVKRQPL SNSDCVLLCL
SISRLFLHGL LFLSAIQLTH FQKLSEPLNH SYQAIIMLWI IANQANLWLA ACLSLLYCSK
LIRFSHTFLI CLASWVSRKI SQMLLGIILC SCICTVLCVW CFFSRPHFTV TTFLFMNNNT
RLNWQIKDLN LFYSFLFCYL WSVPPFLLFL VSSGMLTVSL GRHMRTMKVY TRDSRDPSLE
AHIKALKSLV SFFCFFVISS CAAFISVPLL ILWRNKIGVM VCVGIMAACP SGHAAVLISG
NATLRRAVTT ILLWAQSSMK VRADHKADSR TLC
