T2R38_RAT
ID T2R38_RAT Reviewed; 331 AA.
AC Q4VHE7; Q67ES4;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Taste receptor type 2 member 38;
DE Short=T2R38;
DE AltName: Full=Taste receptor type 2 member 26;
DE Short=T2R26;
GN Name=T2r38 {ECO:0000312|RGD:1560649}; Synonyms=Tas2r26;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAX99135.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley {ECO:0000269|PubMed:15886333};
RX PubMed=15886333; DOI=10.1152/physiolgenomics.00030.2005;
RA Wu S.V., Chen M.C., Rozengurt E.;
RT "Genomic organization, expression, and function of bitter taste receptors
RT (T2R) in mouse and rat.";
RL Physiol. Genomics 22:139-149(2005).
RN [2] {ECO:0000312|EMBL:AAR13355.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAR13355.1};
RA Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT "Identification of new putative rat taste receptors belonging to the T2R
RT family.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in tongue, stomach and duodenum.
CC {ECO:0000269|PubMed:15886333}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY916512; AAX99135.1; -; mRNA.
DR EMBL; AY362746; AAR13355.1; -; Genomic_DNA.
DR RefSeq; NP_001019856.1; NM_001024685.1.
DR AlphaFoldDB; Q4VHE7; -.
DR SMR; Q4VHE7; -.
DR STRING; 10116.ENSRNOP00000028969; -.
DR GlyGen; Q4VHE7; 1 site.
DR PhosphoSitePlus; Q4VHE7; -.
DR PaxDb; Q4VHE7; -.
DR GeneID; 500091; -.
DR KEGG; rno:500091; -.
DR UCSC; RGD:1560649; rat.
DR CTD; 387513; -.
DR RGD; 1560649; T2R38.
DR eggNOG; ENOG502T15G; Eukaryota.
DR InParanoid; Q4VHE7; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; Q4VHE7; -.
DR TreeFam; TF335891; -.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR Reactome; R-RNO-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-RNO-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR PRO; PR:Q4VHE7; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:RGD.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:RGD.
DR InterPro; IPR007960; TAS2R.
DR InterPro; IPR030050; TAS2R38.
DR PANTHER; PTHR11394:SF52; PTHR11394:SF52; 1.
DR Pfam; PF05296; TAS2R; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..331
FT /note="Taste receptor type 2 member 38"
FT /id="PRO_0000247657"
FT TOPO_DOM 1..17
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..94
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 177
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 101
FT /note="S -> I (in Ref. 2; AAR13355)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 331 AA; 37233 MW; E435EDCB9AC664B5 CRC64;
MLTLTPVLTV SYEAKISFLF LSVVEFAVGI MANAFIVLVN FWDMVKKQPL NNCDIALLCL
SITRLFLQGL LLLDAIQLAC FQQMKDPLSH NYQAILTLWM SANQVSLWLA ACLSLLYCAK
IVRFSHTFPL HLASWVSRRF LQMLLVALLF SGVCTALCLW DFFSRSHTVV TSMLHMNNTE
FNLQIEKLNF FYSFVFCNVG SVPPSLVFLI SSGVLVISLG NHMRTMKSQT RGSRDPSLEA
HVRAIIFLVS FLCFYVVSFC AALISIPLLV LWHNKGGVMV CIGMMAACPS GHAAILISGN
AKLKKVIVTI LFWFQSRQKV RRVHKVLPRI L
