T2R39_HUMAN
ID T2R39_HUMAN Reviewed; 338 AA.
AC P59534; A4FUI7; Q3ZCN6; Q645W4;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 3.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Taste receptor type 2 member 39;
DE Short=T2R39;
DE AltName: Full=Taste receptor type 2 member 57;
DE Short=T2R57;
GN Name=TAS2R39;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12379855; DOI=10.1038/ng1014;
RA Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.;
RT "The human TAS2R16 receptor mediates bitter taste in response to beta-
RT glucopyranosides.";
RL Nat. Genet. 32:397-401(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15496549; DOI=10.1093/molbev/msi027;
RA Fischer A., Gilad Y., Man O., Paeaebo S.;
RT "Evolution of bitter taste receptors in humans and apes.";
RL Mol. Biol. Evol. 22:432-436(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP REVIEW.
RX PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA Montmayeur J.-P., Matsunami H.;
RT "Receptors for bitter and sweet taste.";
RL Curr. Opin. Neurobiol. 12:366-371(2002).
RN [5]
RP REVIEW.
RX PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA Margolskee R.F.;
RT "Molecular mechanisms of bitter and sweet taste transduction.";
RL J. Biol. Chem. 277:1-4(2002).
RN [6]
RP REVIEW.
RX PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA Zuker C.S., Ryba N.J.;
RT "Coding of sweet, bitter, and umami tastes: different receptor cells
RT sharing similar signaling pathways.";
RL Cell 112:293-301(2003).
CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC and is gustducin-linked. May play a role in sensing the chemical
CC composition of the gastrointestinal content. The activity of this
CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC tongue and exclusively in gustducin-positive cells.
CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC bitter compounds; individual taste cells can discriminate among bitter
CC stimuli.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM19321.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF494230; AAM19321.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AY724959; AAU21155.1; -; Genomic_DNA.
DR EMBL; BC100947; AAI00948.1; -; mRNA.
DR EMBL; BC100948; AAI00949.1; -; mRNA.
DR EMBL; BC114952; AAI14953.1; -; mRNA.
DR CCDS; CCDS47729.1; -.
DR RefSeq; NP_795362.2; NM_176881.2.
DR AlphaFoldDB; P59534; -.
DR SMR; P59534; -.
DR BioGRID; 129240; 151.
DR IntAct; P59534; 1.
DR STRING; 9606.ENSP00000405095; -.
DR ChEMBL; CHEMBL4523249; -.
DR GlyGen; P59534; 2 sites.
DR iPTMnet; P59534; -.
DR PhosphoSitePlus; P59534; -.
DR BioMuta; TAS2R39; -.
DR DMDM; 55977808; -.
DR PaxDb; P59534; -.
DR PeptideAtlas; P59534; -.
DR PRIDE; P59534; -.
DR Antibodypedia; 57990; 51 antibodies from 17 providers.
DR DNASU; 259285; -.
DR Ensembl; ENST00000446620.1; ENSP00000405095.1; ENSG00000236398.2.
DR GeneID; 259285; -.
DR KEGG; hsa:259285; -.
DR MANE-Select; ENST00000446620.1; ENSP00000405095.1; NM_176881.2; NP_795362.2.
DR UCSC; uc011ksw.2; human.
DR CTD; 259285; -.
DR DisGeNET; 259285; -.
DR GeneCards; TAS2R39; -.
DR HGNC; HGNC:18886; TAS2R39.
DR HPA; ENSG00000236398; Tissue enriched (brain).
DR neXtProt; NX_P59534; -.
DR PharmGKB; PA38739; -.
DR VEuPathDB; HostDB:ENSG00000236398; -.
DR eggNOG; ENOG502SQHF; Eukaryota.
DR GeneTree; ENSGT00960000186638; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; P59534; -.
DR OMA; FMFLNHC; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; P59534; -.
DR TreeFam; TF335891; -.
DR PathwayCommons; P59534; -.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-HSA-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 259285; 15 hits in 1028 CRISPR screens.
DR GeneWiki; TAS2R39; -.
DR GenomeRNAi; 259285; -.
DR Pharos; P59534; Tchem.
DR PRO; PR:P59534; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P59534; protein.
DR Bgee; ENSG00000236398; Expressed in corpus callosum and 1 other tissue.
DR Genevisible; P59534; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0033038; F:bitter taste receptor activity; IDA:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:UniProtKB.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..338
FT /note="Taste receptor type 2 member 39"
FT /id="PRO_0000082281"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..116
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..262
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..291
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..338
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 193
FT /note="S -> F (in dbSNP:rs35474877)"
FT /id="VAR_053348"
FT VARIANT 197
FT /note="K -> E (in dbSNP:rs34169190)"
FT /id="VAR_053349"
SQ SEQUENCE 338 AA; 38626 MW; F9CD1860008198AB CRC64;
MLGRCFPPDT KEKQQLRMTK LCDPAESELS PFLITLILAV LLAEYLIGII ANGFIMAIHA
AEWVQNKAVS TSGRILVFLS VSRIALQSLM MLEITISSTS LSFYSEDAVY YAFKISFIFL
NFCSLWFAAW LSFFYFVKIA NFSYPLFLKL RWRITGLIPW LLWLSVFISF SHSMFCINIC
TVYCNNSFPI HSSNSTKKTY LSEINVVGLA FFFNLGIVTP LIMFILTATL LILSLKRHTL
HMGSNATGSN DPSMEAHMGA IKAISYFLIL YIFNAVALFI YLSNMFDINS LWNNLCQIIM
AAYPASHSIL LIQDNPGLRR AWKRLQLRLH LYPKEWTL
