T2R39_MOUSE
ID T2R39_MOUSE Reviewed; 319 AA.
AC Q7TQA5;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Taste receptor type 2 member 39;
DE Short=T2R39;
DE Short=mT2R34;
GN Name=Tas2r39; Synonyms=T2r34, Tas2r139;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:AAP40340.1};
RN [1] {ECO:0000312|EMBL:AAP40340.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAP40340.1};
RX PubMed=12734386; DOI=10.1152/physiolgenomics.00060.2003;
RA Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.;
RT "Evolutionary relationships of the Tas2r receptor gene families in mouse
RT and human.";
RL Physiol. Genomics 14:73-82(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000303|PubMed:12734386}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AF532790; AAP40340.1; -; Genomic_DNA.
DR EMBL; AC157218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001094; DAA01233.1; -; Genomic_DNA.
DR CCDS; CCDS20061.1; -.
DR RefSeq; NP_851792.1; NM_181275.1.
DR AlphaFoldDB; Q7TQA5; -.
DR SMR; Q7TQA5; -.
DR STRING; 10090.ENSMUSP00000062919; -.
DR GlyGen; Q7TQA5; 4 sites.
DR iPTMnet; Q7TQA5; -.
DR PhosphoSitePlus; Q7TQA5; -.
DR PaxDb; Q7TQA5; -.
DR PRIDE; Q7TQA5; -.
DR Antibodypedia; 57990; 51 antibodies from 17 providers.
DR DNASU; 353148; -.
DR Ensembl; ENSMUST00000057686; ENSMUSP00000062919; ENSMUSG00000047102.
DR GeneID; 353148; -.
DR KEGG; mmu:353148; -.
DR UCSC; uc009bqm.1; mouse.
DR CTD; 353148; -.
DR MGI; MGI:2681308; Tas2r139.
DR VEuPathDB; HostDB:ENSMUSG00000047102; -.
DR eggNOG; ENOG502SQHF; Eukaryota.
DR GeneTree; ENSGT00960000186638; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q7TQA5; -.
DR OMA; WVQKKAI; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; Q7TQA5; -.
DR TreeFam; TF335891; -.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-MMU-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 353148; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q7TQA5; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7TQA5; protein.
DR Bgee; ENSMUSG00000047102; Expressed in embryo.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; NAS:UniProtKB.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..319
FT /note="Taste receptor type 2 member 39"
FT /id="PRO_0000082286"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..247
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 319 AA; 36308 MW; 4D29965B184242D0 CRC64;
MAQPSNYWKQ DVLPLSILML TLVATECTIG IIASGIVMAV NAVSWVQKKA ISITTRILLL
LSVSRIGLQS IMLIEITSSI FNVAFYNSVL YRVSNVSFVF LNYCSLWFAA LLSFFHFVKI
ANFSYPLFFK LKWRISELMP WLLWLSVFIS FSSSMFFSKH KFTVNNNNSL SNNICNFTMK
LYVVETNVVN VSFLFISGIL PPLTMFVATA TLLIFSLRRH TLNMRNSATG SRNPCIEAHM
QAIKETSCFL FLYILNAAAL LLSTSNIVDA SLFWSIVIRI VLPVYPAGHS VLLIQNNPGL
RRTWKHLQSQ IHLYLQNRF
