T2R39_RAT
ID T2R39_RAT Reviewed; 319 AA.
AC Q67ER9;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Taste receptor type 2 member 39;
DE Short=T2R39;
DE AltName: Full=Taste receptor type 2 member 32;
DE Short=T2R32;
GN Name=Tas2r39 {ECO:0000250|UniProtKB:Q7TQA5}; Synonyms=Tas2r32;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:AAR13360.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAR13360.1};
RA Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT "Identification of new putative rat taste receptors belonging to the T2R
RT family.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
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DR EMBL; AY362751; AAR13360.1; -; Genomic_DNA.
DR RefSeq; NP_001074374.1; NM_001080905.1.
DR AlphaFoldDB; Q67ER9; -.
DR SMR; Q67ER9; -.
DR STRING; 10116.ENSRNOP00000035471; -.
DR GlyGen; Q67ER9; 3 sites.
DR PhosphoSitePlus; Q67ER9; -.
DR PaxDb; Q67ER9; -.
DR Ensembl; ENSRNOT00000037220; ENSRNOP00000035471; ENSRNOG00000028135.
DR GeneID; 680188; -.
DR KEGG; rno:680188; -.
DR UCSC; RGD:1595436; rat.
DR CTD; 353148; -.
DR RGD; 1595436; Tas2r39.
DR eggNOG; ENOG502SQHF; Eukaryota.
DR GeneTree; ENSGT00960000186638; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q67ER9; -.
DR OMA; WVQKKAI; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; Q67ER9; -.
DR TreeFam; TF335891; -.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR Reactome; R-RNO-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-RNO-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR PRO; PR:Q67ER9; -.
DR Proteomes; UP000002494; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:RGD.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:RGD.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..319
FT /note="Taste receptor type 2 member 39"
FT /id="PRO_0000247658"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..247
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 319 AA; 36420 MW; F6A2952B95EBA269 CRC64;
MAQPSNYWKQ DLLPLSILIL TLVATECTIG IIASGIITVV NAVSWVQKRA VSITTRILLL
LSVSRIGLQS IILIEMTSSI FNFSSYNSVL YRVSRVSFVF LNYCSLWFAA LLSFFHFVKI
ANFSYPLFFK LKWRISELMP WLLWLSVFIS FSSSMFFCNH KYTVYNNISL SSNICNFTME
LYVAEANVVN VAFLFSFGIL PPLTMFIATA TLLIFSLRRH TLHMRNGDAD SRNPRVEAHK
QAIKETSCFL FLYILYAAVL FLSTSNIADA SLFWSSVLRI SLPVYPAGHS VLLIQSNPGL
KRTWKQLLSQ IHLHLQSRY
