位置:首页 > 蛋白库 > T2R40_MOUSE
T2R40_MOUSE
ID   T2R40_MOUSE             Reviewed;         319 AA.
AC   Q7TQB8;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Taste receptor type 2 member 40;
DE            Short=T2R40;
DE            Short=mT2R33;
GN   Name=Tas2r40; Synonyms=T2r33, Tas2r144, Tas2r44;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000312|EMBL:AAN63043.1};
RN   [1] {ECO:0000312|EMBL:AAN63043.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:AAN63043.1};
RX   PubMed=12734386; DOI=10.1152/physiolgenomics.00060.2003;
RA   Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.;
RT   "Evolutionary relationships of the Tas2r receptor gene families in mouse
RT   and human.";
RL   Physiol. Genomics 14:73-82(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000305}
RP   IDENTIFICATION.
RX   PubMed=12679530; DOI=10.1093/molbev/msg083;
RA   Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT   "Adaptive diversification of bitter taste receptor genes in mammalian
RT   evolution.";
RL   Mol. Biol. Evol. 20:805-814(2003).
CC   -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC       bitter compounds in the oral cavity and the gastrointestinal tract.
CC       Signals through PLCB2 and the calcium-regulated cation channel TRPM5
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY145468; AAN63043.1; -; Genomic_DNA.
DR   EMBL; AC155654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK001095; DAA01234.1; -; Genomic_DNA.
DR   CCDS; CCDS20062.1; -.
DR   RefSeq; NP_001001453.1; NM_001001453.1.
DR   AlphaFoldDB; Q7TQB8; -.
DR   SMR; Q7TQB8; -.
DR   STRING; 10090.ENSMUSP00000067734; -.
DR   GlyGen; Q7TQB8; 2 sites.
DR   PhosphoSitePlus; Q7TQB8; -.
DR   PaxDb; Q7TQB8; -.
DR   PRIDE; Q7TQB8; -.
DR   Antibodypedia; 32610; 17 antibodies from 11 providers.
DR   DNASU; 387515; -.
DR   Ensembl; ENSMUST00000063489; ENSMUSP00000067734; ENSMUSG00000051917.
DR   GeneID; 387515; -.
DR   KEGG; mmu:387515; -.
DR   UCSC; uc009bqn.1; mouse.
DR   CTD; 387515; -.
DR   MGI; MGI:2681312; Tas2r144.
DR   VEuPathDB; HostDB:ENSMUSG00000051917; -.
DR   eggNOG; ENOG502SKRK; Eukaryota.
DR   GeneTree; ENSGT00960000186638; -.
DR   HOGENOM; CLU_072337_3_0_1; -.
DR   InParanoid; Q7TQB8; -.
DR   OMA; NLWLAAW; -.
DR   OrthoDB; 1010573at2759; -.
DR   PhylomeDB; Q7TQB8; -.
DR   TreeFam; TF335891; -.
DR   Reactome; R-MMU-418594; G alpha (i) signalling events.
DR   Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR   Reactome; R-MMU-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR   BioGRID-ORCS; 387515; 1 hit in 72 CRISPR screens.
DR   PRO; PR:Q7TQB8; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q7TQB8; protein.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008527; F:taste receptor activity; NAS:UniProtKB.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..319
FT                   /note="Taste receptor type 2 member 40"
FT                   /id="PRO_0000082314"
FT   TOPO_DOM        1..17
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        18..38
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..66
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        88..97
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..136
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        158..189
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..251
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        273..281
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        303..319
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        178
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   319 AA;  36559 MW;  9508F899390BE4AD CRC64;
     MAIITTNSDY FAHRYEVIIP FVVSTICSIV GIIGNGFITV IYGTEWVRSK RLPTGENLML
     MLSFSRLLLQ IWMMVEITYS LLFPIIYNHN AMYKLFKAIS VFLNYCNLWF AAWLNVFYCL
     KIVNLAHPLF LLMKQKIIGL MPRLLSLSVL VSFSLSSFFS KDILNVYVNT SVPIPSSNST
     KMKYIFMINV LSLAFLYYMG IFLPLFMFIM AATLLITSLK RHTLHMENST TGSRDSSMEA
     HVGAIKSTSH SLILYIINAL ALFISMSNIL GAYSVWNSLC NIIMTAYPAG QSVHLILRNP
     GLRRAWRRFQ HHVHLYLKR
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024