ID   T2R40_PANTR             Reviewed;         323 AA.
AC   Q646B1;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Taste receptor type 2 member 40;
DE            Short=T2R40;
GN   Name=TAS2R40;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15496549; DOI=10.1093/molbev/msi027;
RA   Fischer A., Gilad Y., Man O., Paeaebo S.;
RT   "Evolution of bitter taste receptors in humans and apes.";
RL   Mol. Biol. Evol. 22:432-436(2005).
CC   -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC       bitter compounds in the oral cavity and the gastrointestinal tract.
CC       Signals through PLCB2 and the calcium-regulated cation channel TRPM5
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000305}.
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DR   EMBL; AY724892; AAU21108.1; -; Genomic_DNA.
DR   RefSeq; NP_001009129.1; NM_001009129.1.
DR   RefSeq; XP_016800932.1; XM_016945443.1.
DR   AlphaFoldDB; Q646B1; -.
DR   SMR; Q646B1; -.
DR   STRING; 9598.ENSPTRP00000054248; -.
DR   PaxDb; Q646B1; -.
DR   Ensembl; ENSPTRT00000061705; ENSPTRP00000054248; ENSPTRG00000032460.
DR   Ensembl; ENSPTRT00000102659; ENSPTRP00000077621; ENSPTRG00000046948.
DR   GeneID; 472611; -.
DR   KEGG; ptr:472611; -.
DR   CTD; 259286; -.
DR   VGNC; VGNC:8774; TAS2R40.
DR   eggNOG; ENOG502SKRK; Eukaryota.
DR   GeneTree; ENSGT00960000186638; -.
DR   HOGENOM; CLU_072337_3_0_1; -.
DR   InParanoid; Q646B1; -.
DR   OMA; NLWLAAW; -.
DR   OrthoDB; 1010573at2759; -.
DR   TreeFam; TF335891; -.
DR   Proteomes; UP000002277; Chromosome 7.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..323
FT                   /note="Taste receptor type 2 member 40"
FT                   /id="PRO_0000082290"
FT   TOPO_DOM        1..14
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        15..35
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        36..58
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        122..140
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..190
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        212..247
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        269..276
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..323
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        170
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        179
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   323 AA;  36816 MW;  79476C1367E049D4 CRC64;
     MATVNTDATD KDISKFKVTF TLVVSGIECI TGILGSGFIT AIYGAEWARG KTLPTGDRIM
     LMLSFSRLSL QIWMMLENIF SLLFRIVYNQ NSVYILFKVI TVFLNHSNLW FAAWLKVFYC
     LRIANFNHPL FFLMKRKIIV LMPWLLRLSV LVSLSFSFPL SRDVFNVYVN SSIPIPSSNS
     TEKKYFSETN MVNLVFFYNM GIFVPLIMFI LAATLLILSL KRHTLHMGSN ATGSRDPSMK
     AHIGAIKATS YFLILYIFNA IALFLSMSNI FDTYSSWNIL CKIIMAAYPA GHSVQLILGN
     PGLRRAWKRF QHQVPLYLKG QTL