T2R40_RAT
ID T2R40_RAT Reviewed; 319 AA.
AC Q67ET2;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Taste receptor type 2 member 40;
DE Short=T2R40;
DE AltName: Full=Taste receptor type 2 member 18;
DE Short=T2R18;
GN Name=Tas2r40 {ECO:0000250|UniProtKB:P59535}; Synonyms=T2r18;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:AAR13347.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAR13347.1};
RA Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT "Identification of new putative rat taste receptors belonging to the T2R
RT family.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC bitter compounds in the oral cavity and the gastrointestinal tract.
CC Signals through PLCB2 and the calcium-regulated cation channel TRPM5
CC (By similarity). {ECO:0000250|UniProtKB:P59535}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
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DR EMBL; AY362738; AAR13347.1; -; Genomic_DNA.
DR RefSeq; NP_001020321.1; NM_001025150.1.
DR AlphaFoldDB; Q67ET2; -.
DR SMR; Q67ET2; -.
DR STRING; 10116.ENSRNOP00000033127; -.
DR GlyGen; Q67ET2; 2 sites.
DR PhosphoSitePlus; Q67ET2; -.
DR PaxDb; Q67ET2; -.
DR Ensembl; ENSRNOT00000037194; ENSRNOP00000033127; ENSRNOG00000028130.
DR GeneID; 500101; -.
DR KEGG; rno:500101; -.
DR UCSC; RGD:1562314; rat.
DR CTD; 387515; -.
DR RGD; 1562314; Tas2r40.
DR eggNOG; ENOG502SKRK; Eukaryota.
DR GeneTree; ENSGT00960000186638; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q67ET2; -.
DR OMA; NLWLAAW; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; Q67ET2; -.
DR TreeFam; TF335891; -.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR Reactome; R-RNO-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-RNO-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR PRO; PR:Q67ET2; -.
DR Proteomes; UP000002494; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:RGD.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:RGD.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..319
FT /note="Taste receptor type 2 member 40"
FT /id="PRO_0000249184"
FT TOPO_DOM 1..17
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..66
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 319 AA; 36957 MW; 2515462830905BCC CRC64;
MAIITTDSDY YTHRYEVIIP FVVSTIDCIV GIIGNGFITV IYGTELVRSK RLPTGEHLML
MLSFSRLLLQ IWIMVEITYQ LFFPMIYNHN AMYKLFKTIS VFLNYCNLWF AAWLNVFYCL
KIVNFAHPLF LMMKQKIVVL MPRLMSLSVL VSISLSSFFS KDIFNVYMNT SVPIPFSNST
KMKYFFKTNV LNLAFLYYMG IFIPLFMFIM AAILLITSLK RHTLNMESST TGSRDSSMEA
HLGAIKSTSY SLILYIINAL ALFISMSNIF GAYSTWNSVC SFILTAYPAG QSVHLILRNP
GLRRAWRRFQ HHVRLYLKR
