T2R42_HUMAN
ID T2R42_HUMAN Reviewed; 314 AA.
AC Q7RTR8; A2RRP4; Q645X0;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Taste receptor type 2 member 42;
DE Short=T2R42;
DE AltName: Full=Taste receptor type 2 member 55;
DE Short=T2R55;
GN Name=TAS2R42; Synonyms=TAS2R55;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15496549; DOI=10.1093/molbev/msi027;
RA Fischer A., Gilad Y., Man O., Paeaebo S.;
RT "Evolution of bitter taste receptors in humans and apes.";
RL Mol. Biol. Evol. 22:432-436(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS PHE-175;
RP SER-196; TRP-255 AND PRO-311.
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC and is gustducin-linked. May play a role in sensing the chemical
CC composition of the gastrointestinal content. The activity of this
CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC bitter compounds; individual taste cells can discriminate among bitter
CC stimuli.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AY724953; AAU21149.1; -; Genomic_DNA.
DR EMBL; AC010176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC131742; AAI31743.1; -; mRNA.
DR EMBL; BK001099; DAA01206.1; -; Genomic_DNA.
DR CCDS; CCDS31747.1; -.
DR AlphaFoldDB; Q7RTR8; -.
DR SMR; Q7RTR8; -.
DR STRING; 9606.ENSP00000334050; -.
DR ChEMBL; CHEMBL4523360; -.
DR GlyGen; Q7RTR8; 1 site.
DR BioMuta; TAS2R42; -.
DR DMDM; 55976719; -.
DR PaxDb; Q7RTR8; -.
DR PRIDE; Q7RTR8; -.
DR Antibodypedia; 23426; 37 antibodies from 14 providers.
DR Ensembl; ENST00000334266.1; ENSP00000334050.1; ENSG00000186136.1.
DR UCSC; uc031yun.1; human.
DR GeneCards; TAS2R42; -.
DR HGNC; HGNC:18888; TAS2R42.
DR HPA; ENSG00000186136; Not detected.
DR MIM; 613966; gene.
DR neXtProt; NX_Q7RTR8; -.
DR PharmGKB; PA38741; -.
DR VEuPathDB; HostDB:ENSG00000186136; -.
DR eggNOG; ENOG502TCTX; Eukaryota.
DR HOGENOM; CLU_072337_2_0_1; -.
DR InParanoid; Q7RTR8; -.
DR PhylomeDB; Q7RTR8; -.
DR TreeFam; TF335891; -.
DR PathwayCommons; Q7RTR8; -.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Pharos; Q7RTR8; Tchem.
DR PRO; PR:Q7RTR8; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q7RTR8; protein.
DR Bgee; ENSG00000186136; Expressed in tonsil and 12 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..314
FT /note="Taste receptor type 2 member 42"
FT /id="PRO_0000082344"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..265
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 175
FT /note="Y -> F (in dbSNP:rs35969491)"
FT /evidence="ECO:0000269|PubMed:16541075"
FT /id="VAR_062086"
FT VARIANT 196
FT /note="F -> S (in dbSNP:rs5020531)"
FT /evidence="ECO:0000269|PubMed:16541075"
FT /id="VAR_053352"
FT VARIANT 255
FT /note="G -> W (in dbSNP:rs1669413)"
FT /evidence="ECO:0000269|PubMed:16541075"
FT /id="VAR_062087"
FT VARIANT 265
FT /note="Y -> C (in dbSNP:rs1451772)"
FT /id="VAR_053353"
FT VARIANT 292
FT /note="R -> Q (in dbSNP:rs1669412)"
FT /id="VAR_062088"
FT VARIANT 311
FT /note="A -> P (in dbSNP:rs1650017)"
FT /evidence="ECO:0000269|PubMed:16541075"
FT /id="VAR_062089"
SQ SEQUENCE 314 AA; 36195 MW; 0A49C39889F8CFA4 CRC64;
MATELDKIFL ILAIAEFIIS MLGNVFIGLV NCSEGIKNQK VFSADFILTC LAISTIGQLL
VILFDSFLVG LASHLYTTYR LGKTVIMLWH MTNHLTTWLA TCLSIFYFFK IAHFPHSLFL
WLRWRMNGMI VMLLILSLFL LIFDSLVLEI FIDISLNIID KSNLTLYLDE SKTLYDKLSI
LKTLLSLTSF IPFSLFLTSL LFLFLSLVRH TRNLKLSSLG SRDSSTEAHR RAMKMVMSFL
FLFIVHFFSL QVANGIFFML WNNKYIKFVM LALNAFPSCH SFILILGNSK LRQTAVRLLW
HLRNYTKTPN ALPL
