T2R43_MACMU
ID T2R43_MACMU Reviewed; 308 AA.
AC Q645T3;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Taste receptor type 2 member 43;
DE Short=T2R43;
GN Name=TAS2R43;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15496549; DOI=10.1093/molbev/msi027;
RA Fischer A., Gilad Y., Man O., Paeaebo S.;
RT "Evolution of bitter taste receptors in humans and apes.";
RL Mol. Biol. Evol. 22:432-436(2005).
CC -!- FUNCTION: Gustducin-coupled receptor immplicated in the perception of
CC bitter compounds in the oral cavity and the gastrointestinal tract.
CC Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
CC Activated by the sulfonyl amide sweeteners saccharin and acesulfame K.
CC In airway epithelial cells, binding of bitter compounds increases the
CC intracellular calcium ion concentration and stimulates ciliary beat
CC frequency. May act as chemosensory receptors in airway epithelial cells
CC to detect and eliminate potential noxious agents from the airways (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell
CC projection, cilium membrane {ECO:0000250}. Note=In airway epithelial
CC cells, localizes to motile cilia. {ECO:0000250}.
CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC bitter compounds; individual taste cells can discriminate among bitter
CC stimuli.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AY725007; AAU21186.1; -; Genomic_DNA.
DR AlphaFoldDB; Q645T3; -.
DR SMR; Q645T3; -.
DR STRING; 9544.ENSMMUP00000027633; -.
DR eggNOG; ENOG502TE6U; Eukaryota.
DR InParanoid; Q645T3; -.
DR Proteomes; UP000006718; Unplaced.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cell projection; Cilium; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Sensory transduction;
KW Taste; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..308
FT /note="Taste receptor type 2 member 43"
FT /id="PRO_0000082303"
FT TOPO_DOM 1
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 2..22
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 23..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..178
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..249
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..258
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 308 AA; 35353 MW; 843968D139867EF2 CRC64;
MITFLPIIFS ILVVFTFVIG NFANGFIALV NSIEWVKRQK ISFADQILTA LAVSRVGLLW
ILLLNWYSTV LNPAFYSVEV RTIAYNLWAV INHFSNWLAT SLSIFYLLKI ANFSNLIFLH
LRRRVKSVVL VILWGPLLFL VCHLFVVNMN EIIQTKEYEG NMTWKSKLRS AMYLSNTTVT
ILANLVPFIL TLISFLLLIC SLCKHLKKMQ LRDKGSQDPS TKVHIKALQT VISLSLCAIY
FLSIMISSWS LGRVENKAIF MFCKAIRFSY PSAHAFILIW GNKKLKQTLL SVLWNVRYCV
KGQKLQSP
