T2R43_PANTR
ID T2R43_PANTR Reviewed; 309 AA.
AC Q646B4;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Taste receptor type 2 member 43;
DE Short=T2R43;
GN Name=TAS2R43;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15496549; DOI=10.1093/molbev/msi027;
RA Fischer A., Gilad Y., Man O., Paeaebo S.;
RT "Evolution of bitter taste receptors in humans and apes.";
RL Mol. Biol. Evol. 22:432-436(2005).
CC -!- FUNCTION: Gustducin-coupled receptor immplicated in the perception of
CC bitter compounds in the oral cavity and the gastrointestinal tract.
CC Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
CC Activated by the sulfonyl amide sweeteners saccharin and acesulfame K.
CC In airway epithelial cells, binding of bitter compounds increases the
CC intracellular calcium ion concentration and stimulates ciliary beat
CC frequency. May act as chemosensory receptors in airway epithelial cells
CC to detect and eliminate potential noxious agents from the airways (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell
CC projection, cilium membrane {ECO:0000250}. Note=In airway epithelial
CC cells, localizes to motile cilia. {ECO:0000250}.
CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC bitter compounds; individual taste cells can discriminate among bitter
CC stimuli.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AY724889; AAU21105.1; -; Genomic_DNA.
DR AlphaFoldDB; Q646B4; -.
DR SMR; Q646B4; -.
DR STRING; 9598.ENSPTRP00000054709; -.
DR PaxDb; Q646B4; -.
DR eggNOG; ENOG502TE6U; Eukaryota.
DR InParanoid; Q646B4; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cell projection; Cilium; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Sensory transduction;
KW Taste; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Taste receptor type 2 member 43"
FT /id="PRO_0000082305"
FT TOPO_DOM 1
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 2..22
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 23..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..178
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..259
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 309 AA; 35612 MW; 504332C099242D52 CRC64;
MITFLPIIFS SLVVVTFVIG NFANGFIALV NSIEWFKRQK ISFADQILTA LAVSRVGLLW
VLLLNWYSTV LNPAFNSVEV RTTAYNIWAV INHFSNWLAT SLSIFYLLKI ANFSNFIFLH
LKRRVKSVIL VMLLGPLLFL ACHLFVINMN EIVRTKEFEG NMTWKIKLKS AMYFSNMTVT
MVANLVPFTL TLLSFLLLIC SLCKHLKKMQ LHGKGSQDPS TKVHIKVLQT VISFLLLCAI
YFLSIMISVW SFGSLKNKPV FMFCKAMRFS YPSIHPFILI WGNKKLKQTF LSVFWQMRYW
VKGEKTSSP
