ID   BPHB_PSEFK              Reviewed;         275 AA.
AC   P08694;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase;
DE            EC=1.3.1.56;
DE   AltName: Full=2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase;
DE   AltName: Full=2,3-dihydroxy-4-phenylhexa-4,6-diene dehydrogenase;
DE   AltName: Full=Biphenyl-2,3-dihydro-2,3-diol dehydrogenase;
DE   AltName: Full=Biphenyl-cis-diol dehydrogenase;
GN   Name=bphB;
OS   Pseudomonas furukawaii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas;
OC   Pseudomonas oleovorans/pseudoalcaligenes group.
OX   NCBI_TaxID=1149133;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 10086 / NBRC 110670 / KF707;
RX   PubMed=3793719; DOI=10.1128/jb.169.1.427-429.1987;
RA   Furukawa K., Arimura N., Miyazaki T.;
RT   "Nucleotide sequence of the 2,3-dihydroxybiphenyl dioxygenase gene of
RT   Pseudomonas pseudoalcaligenes.";
RL   J. Bacteriol. 169:427-429(1987).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) =
CC         biphenyl-2,3-diol + H(+) + NADH; Xref=Rhea:RHEA:17033,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16205, ChEBI:CHEBI:32922,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.56;
CC   -!- PATHWAY: Xenobiotic degradation; biphenyl degradation; 2-hydroxy-2,4-
CC       pentadienoate and benzoate from biphenyl: step 2/4.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA25752.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M15333; AAA25752.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; P08694; -.
DR   SMR; P08694; -.
DR   STRING; 1149133.ppKF707_3401; -.
DR   UniPathway; UPA00155; UER00251.
DR   GO; GO:0018509; F:cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR017711; BphB_TodD.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR03325; BphB_TodD; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; NAD; Oxidoreductase.
FT   CHAIN           1..275
FT                   /note="Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase"
FT                   /id="PRO_0000054533"
FT   ACT_SITE        153
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         9..33
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         140
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   275 AA;  28726 MW;  F32A4A870B47E566 CRC64;
     MKLKGEAVLI TGGASGLGRA LVDRFVAEAK VAVLDKSAER LAELETDLGD NVLGIVGDVR
     SLEDQKQAAS RCVARFGKID TLIPNAGIWD YSTALVDLPE ESLDAAFDEV FHINVKGYIH
     AVKALPALVA SRGNVIFTIS NAGFYPNGGG PLYTAAKQAI VGLVRELAFE LAPYVRVNGV
     GPGGMNSDMR GPSSLGMGSK AISTVPLADM LKSVLPIGRM PEVEEYTGAY VFFATRGDAA
     PASGALVNYD GGLGVRGFFS GAGGNDLLEQ LNIHP