ID   T2R46_MACMU             Reviewed;         308 AA.
AC   Q645T4;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Taste receptor type 2 member 46;
DE            Short=T2R46;
GN   Name=TAS2R46;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15496549; DOI=10.1093/molbev/msi027;
RA   Fischer A., Gilad Y., Man O., Paeaebo S.;
RT   "Evolution of bitter taste receptors in humans and apes.";
RL   Mol. Biol. Evol. 22:432-436(2005).
CC   -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC       and is gustducin-linked. May play a role in sensing the chemical
CC       composition of the gastrointestinal content. The activity of this
CC       receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC       and lead to the gating of TRPM5 (By similarity). In airway epithelial
CC       cells, binding of bitter compounds increases the intracellular calcium
CC       ion concentration and stimulates ciliary beat frequency (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell
CC       projection, cilium membrane. Note=In airway epithelial cells, localizes
CC       to motile cilia. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC       bitter compounds; individual taste cells can discriminate among bitter
CC       stimuli.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000305}.
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DR   EMBL; AY725005; AAU21185.1; -; Genomic_DNA.
DR   RefSeq; NP_001074226.1; NM_001080757.2.
DR   RefSeq; XP_015006561.1; XM_015151075.1.
DR   RefSeq; XP_015006562.1; XM_015151076.1.
DR   RefSeq; XP_015006563.1; XM_015151077.1.
DR   AlphaFoldDB; Q645T4; -.
DR   SMR; Q645T4; -.
DR   GeneID; 694814; -.
DR   KEGG; mcc:694814; -.
DR   CTD; 259292; -.
DR   eggNOG; ENOG502TE6U; Eukaryota.
DR   HOGENOM; CLU_072337_2_0_1; -.
DR   InParanoid; Q645T4; -.
DR   OMA; MILSVWN; -.
DR   OrthoDB; 1339037at2759; -.
DR   TreeFam; TF335891; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cell projection; Cilium; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Sensory transduction;
KW   Taste; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..308
FT                   /note="Taste receptor type 2 member 46"
FT                   /id="PRO_0000082319"
FT   TOPO_DOM        1
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        2..22
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        23..46
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        68..86
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..126
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        148..178
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        200..229
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        251..258
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..279
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        280..308
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        161
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        176
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   308 AA;  35462 MW;  985576F9F5142858 CRC64;
     MITFLSITFS ILVGVIFVIG NFANGFIALV NSIEWVKRQK ISFADQILTG LAVSRVGLLW
     VLLLHLYATE FNLAFYSVEV RITAYNVWIV TNHFSNWLST SLSMFYLLKI ATFSNLIFLH
     LKRKVKSVIL VTLLGPLLFL VCHLFVMNMN HIVWRKEYEG NITWRIKLRS AMYLSNVTVT
     MLANLIPLTL TLMSFLLLIC SLCKHLKKMQ VHGKGSQDPS TKVHIKALQT VTSFLLLCAI
     YFLSMILSVW NFELEKKPVF MFCQAVIFSY PSTHPLILIW GNKKLKQIFL SVLWNVRYWV
     KGQKPSSP