T2R46_PANPA
ID T2R46_PANPA Reviewed; 309 AA.
AC Q646E1; Q5Y4Z7;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=Taste receptor type 2 member 46;
DE Short=T2R46;
GN Name=TAS2R46;
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15496549; DOI=10.1093/molbev/msi027;
RA Fischer A., Gilad Y., Man O., Paeaebo S.;
RT "Evolution of bitter taste receptors in humans and apes.";
RL Mol. Biol. Evol. 22:432-436(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15466715; DOI=10.1073/pnas.0404894101;
RA Parry C.M., Erkner A., le Coutre J.;
RT "Divergence of T2R chemosensory receptor families in humans, bonobos, and
RT chimpanzees.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14830-14834(2004).
CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC and is gustducin-linked. May play a role in sensing the chemical
CC composition of the gastrointestinal content. The activity of this
CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC and lead to the gating of TRPM5 (By similarity). In airway epithelial
CC cells, binding of bitter compounds increases the intracellular calcium
CC ion concentration and stimulates ciliary beat frequency (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell
CC projection, cilium membrane. Note=In airway epithelial cells, localizes
CC to motile cilia. {ECO:0000250}.
CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC bitter compounds; individual taste cells can discriminate among bitter
CC stimuli.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AY724848; AAU21078.1; -; Genomic_DNA.
DR EMBL; AY677150; AAV28578.1; -; Genomic_DNA.
DR AlphaFoldDB; Q646E1; -.
DR SMR; Q646E1; -.
DR STRING; 9597.XP_003829654.1; -.
DR eggNOG; ENOG502TE6U; Eukaryota.
DR Proteomes; UP000240080; Unplaced.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cell projection; Cilium; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Sensory transduction;
KW Taste; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Taste receptor type 2 member 46"
FT /id="PRO_0000082320"
FT TOPO_DOM 1
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 2..22
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 23..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..178
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..259
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 177
FT /note="I -> T (in Ref. 2; AAV28578)"
FT /evidence="ECO:0000305"
FT CONFLICT 305
FT /note="E -> K (in Ref. 2; AAV28578)"
FT /evidence="ECO:0000305"
FT CONFLICT 309
FT /note="P -> S (in Ref. 2; AAV28578)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 309 AA; 35644 MW; D1CF5966165C2B73 CRC64;
MITFLPIIFS ILIVVTFVIG NFANGFIALA NSIEWFKRQK ISFADQILTA LAVSRVGLLW
VLLLNWYATE LNPAFYSIEV RITAYNLWAV INHFSNWLAT SLSIFYLLKI ANFSNLIFLR
LKRRVKSVVL VILLGPLLFL VCHLFVINMN QIIWTKEYEG NMTWKIKLRS AMYLSNITVT
ILANLVPFTL TLISFLLLIC SLCKHLKKMQ LHGKGSQDPS MKVHIKALQT VTSFLLLCAI
YFLSIIMSVW SFESLENKPV FMFCEAITFS YPSTHPFILI WGNKKLKQTF LSVLWHVRYW
VKGEEPSSP
