T2R60_PANTR
ID T2R60_PANTR Reviewed; 318 AA.
AC Q646A5;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Taste receptor type 2 member 60;
DE Short=T2R60;
DE AltName: Full=T2R56;
GN Name=TAS2R60;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15496549; DOI=10.1093/molbev/msi027;
RA Fischer A., Gilad Y., Man O., Paeaebo S.;
RT "Evolution of bitter taste receptors in humans and apes.";
RL Mol. Biol. Evol. 22:432-436(2005).
CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC and is gustducin-linked. May play a role in sensing the chemical
CC composition of the gastrointestinal content. The activity of this
CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC bitter compounds; individual taste cells can discriminate among bitter
CC stimuli.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AY724901; AAU21114.1; -; Genomic_DNA.
DR RefSeq; NP_001009140.1; NM_001009140.1.
DR RefSeq; XP_016800913.1; XM_016945424.1.
DR AlphaFoldDB; Q646A5; -.
DR SMR; Q646A5; -.
DR STRING; 9598.ENSPTRP00000033935; -.
DR PaxDb; Q646A5; -.
DR Ensembl; ENSPTRT00000036697; ENSPTRP00000033935; ENSPTRG00000019812.
DR Ensembl; ENSPTRT00000106268; ENSPTRP00000071296; ENSPTRG00000045590.
DR GeneID; 493890; -.
DR KEGG; ptr:493890; -.
DR CTD; 338398; -.
DR VGNC; VGNC:8777; TAS2R60.
DR eggNOG; ENOG502S2SI; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_1_1_1; -.
DR InParanoid; Q646A5; -.
DR OMA; FCLQWVV; -.
DR OrthoDB; 1010573at2759; -.
DR TreeFam; TF335891; -.
DR Proteomes; UP000002277; Chromosome 7.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..318
FT /note="Taste receptor type 2 member 60"
FT /id="PRO_0000082354"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..40
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..88
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..264
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 318 AA; 36412 MW; 3D2B9FAC7A8AE330 CRC64;
MNGDHMVLGS SVTDKKAIIL VTILLLLRLV AIAGNGFITA ALGVEWVLRR MLLPCDKLLV
SLGASHFCLQ SVVMGKTIYV FLYPMAFPYN PVLQFLAFQW DFLNAATLWF STWLSVFYCV
KIATFTHPVF FWLKHKLSGW LPWMVFSYVG LSSFTTILFF IGNHRMYQNY LKNHLQPWNV
TGNSIRSYCE KFYLFPLKMI TWTMPTAVFF ICMILLITSL GRHMKKALLT TSGFREPSVQ
AHIKALLALL SFAMLFISYF LSLVFSAAGI FPPLDFKFWV WESVIYLCAA VHPIILLFSN
CRLRAVLKSR RSSRCGTP
