ID   T2R62_PANPA             Reviewed;         312 AA.
AC   Q5Y4Z0;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Taste receptor type 2 member 62;
DE            Short=T2R62;
GN   Name=TAS2R62;
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15466715; DOI=10.1073/pnas.0404894101;
RA   Parry C.M., Erkner A., le Coutre J.;
RT   "Divergence of T2R chemosensory receptor families in humans, bonobos, and
RT   chimpanzees.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14830-14834(2004).
CC   -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC       and is gustducin-linked. May play a role in sensing the chemical
CC       composition of the gastrointestinal content. The activity of this
CC       receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC       and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC       bitter compounds; individual taste cells can discriminate among bitter
CC       stimuli.
CC   -!- MISCELLANEOUS: The human orthologous protein does not exist, its gene
CC       is a pseudogene.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000305}.
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DR   EMBL; AY677157; AAV28585.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5Y4Z0; -.
DR   SMR; Q5Y4Z0; -.
DR   STRING; 9597.XP_003820625.1; -.
DR   eggNOG; ENOG502S2SI; Eukaryota.
DR   Proteomes; UP000240080; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Taste receptor type 2 member 62"
FT                   /id="PRO_0000082356"
FT   TOPO_DOM        1..4
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        5..27
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..39
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..62
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        63..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..104
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..127
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..150
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        151..182
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..205
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206..231
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..254
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        255..258
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..281
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        282..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        162
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   312 AA;  35460 MW;  D636E747A8518053 CRC64;
     MPSLPTLIFI AIFCLESLAA MLQNGFLVTM LGREWVRCRM LSTSDMIVAC LAASRFCLHG
     VAMANNLLAS LDFSRAVPYM NIFWDLFNAL TLWFTALLAA FYCVKISSFS HPTFAWLKWR
     ISRLVPKLIK GSLIICGLEV ISSATGNILF GQRKVSLSSY RNETLVYRVQ ASFQLYFFLY
     DGFVWSIPFL LFLVSTVLLI VSLCWQLGQM RDLRPGPCDP STQAYTMALK SLTFSLIFCT
     LYFLSLFASA LKIINFQNHW HWAWEVLIYA NICLHSTVLV LRSPKLKKGL KTWPQLQCPC
     DAGSQGFGRC WP