ID   T2TA_HELPY              Reviewed;         193 AA.
AC   O25042;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2001, sequence version 2.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Probable type II restriction enzyme HpyAORF263P {ECO:0000303|PubMed:12654995};
DE            Short=HpyAORF263P;
DE            EC=3.1.21.4;
DE   AltName: Full=Endonuclease HpyAORF263P;
DE   AltName: Full=Type-2 restriction enzyme HpyAORF263P;
GN   Name=hpyAIR {ECO:0000305}; OrderedLocusNames=HP_0262;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
RN   [2]
RP   NOMENCLATURE, AND SUBTYPE.
RX   PubMed=12654995; DOI=10.1093/nar/gkg274;
RA   Roberts R.J., Belfort M., Bestor T., Bhagwat A.S., Bickle T.A.,
RA   Bitinaite J., Blumenthal R.M., Degtyarev S.K., Dryden D.T., Dybvig K.,
RA   Firman K., Gromova E.S., Gumport R.I., Halford S.E., Hattman S.,
RA   Heitman J., Hornby D.P., Janulaitis A., Jeltsch A., Josephsen J., Kiss A.,
RA   Klaenhammer T.R., Kobayashi I., Kong H., Krueger D.H., Lacks S.,
RA   Marinus M.G., Miyahara M., Morgan R.D., Murray N.E., Nagaraja V.,
RA   Piekarowicz A., Pingoud A., Raleigh E., Rao D.N., Reich N., Repin V.E.,
RA   Selker E.U., Shaw P.C., Stein D.C., Stoddard B.L., Szybalski W.,
RA   Trautner T.A., Van Etten J.L., Vitor J.M., Wilson G.G., Xu S.Y.;
RT   "A nomenclature for restriction enzymes, DNA methyltransferases, homing
RT   endonucleases and their genes.";
RL   Nucleic Acids Res. 31:1805-1812(2003).
CC   -!- FUNCTION: A P subtype probable restriction enzyme that recognizes the
CC       double-stranded sequence CCGG; the cleavage site is unknown.
CC       {ECO:0000303|PubMed:12654995}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of DNA to give specific double-
CC         stranded fragments with terminal 5'-phosphates.; EC=3.1.21.4;
CC   -!- SIMILARITY: Belongs to the BsaWI type II restriction endonuclease
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD07336.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE000511; AAD07336.1; ALT_INIT; Genomic_DNA.
DR   PIR; F64552; F64552.
DR   RefSeq; NP_207060.1; NC_000915.1.
DR   AlphaFoldDB; O25042; -.
DR   DIP; DIP-3315N; -.
DR   IntAct; O25042; 3.
DR   MINT; O25042; -.
DR   STRING; 85962.C694_01325; -.
DR   REBASE; 4213; HpyAORF263P.
DR   PaxDb; O25042; -.
DR   EnsemblBacteria; AAD07336; AAD07336; HP_0262.
DR   KEGG; hpy:HP_0262; -.
DR   PATRIC; fig|85962.8.peg.273; -.
DR   eggNOG; ENOG5031ACM; Bacteria.
DR   OMA; AKCINGE; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   InterPro; IPR041551; RE_BsaWI.
DR   Pfam; PF18643; RE_BsaWI; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; Restriction system.
FT   CHAIN           1..193
FT                   /note="Probable type II restriction enzyme HpyAORF263P"
FT                   /id="PRO_0000128680"
SQ   SEQUENCE   193 AA;  22707 MW;  3D6ED5D4F00B4945 CRC64;
     MFGLGLADVI LERFKDFMRE QPEPYKFLQV FYAQEKERFL NHKMSDYIKQ NKSKEEASIL
     ARQGFVSAVG RALEKIIELL LKDFCIKNNV KMTNDKILRA KRINGELDRV KRALWVHFGE
     YSVLPDIILY QTNKDNIKIL AILSVKNSFR ERFTETPYWK LKLLQSPVTS HIKVFMITPD
     NDDEISFKDK PKG